Esentra 2mg Tablet

Written By Dr. Lipika Khurana, PGDHHM, BDS

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 07 Apr 2026 | 02:54 PM (IST)

Esentra 2mg Tablet is used to treat insomnia. It reduces sleep onset time and frequent awakening at night. This medicine improves sleep maintenance and therefore ensures sound sleep.

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General Information

Contains

Eszopiclone (2mg)

Marketer

Intas Pharmaceuticals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Esentra 2mg Tablet should be taken on an empty stomach, preferably before going to bed. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it is habit-forming. Do not stop taking it suddenly without talking to your doctor as it may worsen your symptoms.

Some common side effects of this medicine include headache, taste changes, dry mouth, rash, anxiety, respiratory tract infections, or viral infections. However, these are temporary and resolve on their own after some time. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you and do not take alcohol with it as it may worsen the dizziness. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, hallucinations, or suicidal thoughts while taking this medicine.

Consult your doctor before taking this medicine if you are suffering from any liver or kidney problems. You should avoid smoking and alcohol while using this medicine. Pregnant and breastfeeding mothers should not use this medicine. However, if the need arises, please consult your doctor before using it.

Uses of Esentra Tablet

Insomnia

Benefits of Esentra Tablet

Insomnia
Insomnia is a sleep disorder where a person finds it difficult to fall asleep, stay asleep, or wake up feeling rested. Over time, it can lead to fatigue, poor concentration, irritability, and a decline in overall health and daily functioning. Esentra 2mg Tablet helps people fall asleep faster, stay asleep longer, and experience better sleep quality throughout the night. This leads to improved energy levels, sharper focus, better mood, and a more balanced daily routine, allowing individuals to function better both mentally and physically.

Side effects of Esentra Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Esentra

Sleepiness
Dizziness
Headache
Rash
Anxiety
Hallucination
Respiratory tract infection
Viral infection
Taste change
Dryness in mouth

How to use Esentra Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Esentra 2mg Tablet is to be taken on an empty stomach.

How Esentra Tablet works

Esentra 2mg Tablet belongs to a group of medicines called sedative-hypnotics. It works by slowing activity of the nerve cells in the brain and helps fall asleep.

Quick tips

Your doctor has prescribed Esentra 2mg Tablet to help you fall asleep faster and sleep for longer.
It is best taken without food as a high-fat meal can reduce its absorption and effect.
Take it 30 to 45 minutes before bedtime and only when you have time to sleep for at least 7 hours.
It makes you feel dizzy next morning. Don't drive or do anything requiring concentration until you know how it affects you.
It does not affect total sleep time. However, it reduces sleep onset time and frequent awakening at night.
Never share your medication with any other person who also has a sleep problem.
Inform your doctor if your sleep doesn’t improve after 7 to 10 days of treatment.
Stop taking medication and inform your doctor If you experience sleep driving or memory loss.
Inform your doctor if you notice behavioral changes, new or worsening depression or suicidal thoughts.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Inform your doctor if you have a history of depression, drug/alcohol abuse, and liver disease.
Do not stop taking medication suddenly as it may lead to anxiety, mood changes, and restlessness.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Esentra 2mg Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Esentra 2mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CAUTION

Esentra 2mg Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Esentra 2mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

SAFE IF PRESCRIBED

Esentra 2mg Tablet is safe to use in patients with kidney disease. No dose adjustment is recommended.

Liver

CAUTION

Esentra 2mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Esentra with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Mifepristone (Oral Route)

Watch out for symptoms of Eszopiclone side effects such as sleepiness, dizziness, headache, dry mouth, rash or anxiety and consult your doctor if you experience them. They may adjust the dose of Eszopiclone accordingly. Mifepristone may raise blood levels of Eszopiclone.

Moderate

Itraconazole (Oral Route)

Your doctor may monitor the effects of Eszopiclone and adjust the dose as per the observations. Avoid driving or undertaking other tasks requiring skill and alertness. Itraconazole may raise blood levels of Eszopiclone.

Moderate

Itraconazole (Injection Route)

Moderate

Ketoconazole (Oral Route)

Your doctor may monitor the effects of Eszopiclone and adjust the dose as per the observations. Avoid driving or undertaking other tasks requiring skill and alertness. Ketoconazole may raise blood levels of Eszopiclone.

Moderate

Ketoconazole (Injection Route)

Frequently asked questions

How long does it take for Esentra 2mg Tablet to work?

Esentra 2mg Tablet starts working shortly after you take it. The maximum levels of Esentra 2mg Tablet are reached within an hour of taking it. Taking Esentra 2mg Tablet may make you feel sleepy and sleepiness may persist for some time. This is the reason that you should prefer taking Esentra 2mg Tablet immediately before you go to bed, or after you have gone to bed but could not fall asleep. Moreover, take Esentra 2mg Tablet only if you know that you will be able to stay in bed for at least 7 to 8 hours after taking the medication.

Does Esentra 2mg Tablet have abuse potential?

Yes, Esentra 2mg Tablet does have abuse potential. The risk of abuse increases with the dose and duration of treatment and concomitant use of other psychoactive drugs. The risk is also greater for patients who have a history of alcohol or drug abuse or history of psychiatric disorders.

What are the symptoms of overdose of Esentra 2mg Tablet?

An overdose of medicine can make you feel confused, drowsy, dizzy, and lightheaded. It may also lead to difficulty in breathing, floppy muscles (hypotonia), and loss of balance which may make you fall over. You may sleep deeply and possibly fall into a coma. The underlying reason of these symptoms could be low blood pressure due to overdose of Esentra 2mg Tablet.

How long should I take Esentra 2mg Tablet?

Treatment should be as short as possible and should not exceed four weeks which includes the period of slowly decreasing the dose. For transient sleeplessness, the recommended duration is 2-5 days and for short lived sleeplessness duration should be 2-3 weeks.

Can I drink alcohol with Esentra 2mg Tablet?

Do not drink alcohol while you are taking Esentra 2mg Tablet. Alcohol can increase the effects of Esentra 2mg Tablet and make you sleep very deeply so that you do not breathe properly or have difficulty waking.

Is Esentra 2mg Tablet safe to take?

Yes, Esentra 2mg Tablet is safe to take if taken at the prescribed dose and for a short duration (less than 4 weeks). If the dose and duration is increased then risk of abuse and dependence on the medicine is more likely to occur.

Does Esentra 2mg Tablet affect memory?

Memory impairment is rare, but may occur, especially when sleep is interrupted or there is a delay in going to bed after taking the tablet. Therefore to reduce such possibility of memory impairment, patients should ensure that they are taking the tablet when they are able to have a full night's sleep (uninterrupted sleep of about 7 to 8 hours).

Can I drive after taking Esentra 2mg Tablet?

Esentra 2mg Tablet can cause slowing of your normal brain function (central nervous system depression) which may adversely affect the ability to drive or to use machines. It can be very unsafe if a patient drives within 12 hours of taking Esentra 2mg Tablet.

Fact Box

Chemical Class

Cyclopyrrolones

Habit Forming

Yes

Therapeutic Class

NEURO CNS

Action Class

Non-Benzodiazepine Hypnotics (Z-Drugs)

References

Stahl SM. Eszopiclone. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, NY: Cambridge University Press; 2014. pp. 235-38.
Mihic SJ, Harris RA. Hypnotics and Sedatives. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 468.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 502.
Eszopiclone. Marlborough: Sunovion Pharmaceuticals; 2004 [revised May 2014]. [Accessed 25 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Eszopiclone. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:
Eszopiclone. Dawsonville, GA: Direct Rx; 2023. [Accessed 19 Jan. 2026] (online). Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Esentra 2mg Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Esentra Tablet

Benefits of Esentra Tablet

Side effects of Esentra Tablet

How to use Esentra Tablet

How Esentra Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Mifepristone (Oral Route)

Itraconazole (Oral Route)

Itraconazole (Injection Route)

Ketoconazole (Oral Route)

Ketoconazole (Injection Route)

Frequently asked questions

How long does it take for Esentra 2mg Tablet to work?

Does Esentra 2mg Tablet have abuse potential?

What are the symptoms of overdose of Esentra 2mg Tablet?

How long should I take Esentra 2mg Tablet?

Can I drink alcohol with Esentra 2mg Tablet?

Is Esentra 2mg Tablet safe to take?

Does Esentra 2mg Tablet affect memory?

Can I drive after taking Esentra 2mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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