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Enapraz Injection

Esomeprazole (40mg)
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Enapraz Injection is a medicine that reduces the amount of acid produced in your stomach. It is used for treating acid-related diseases of the stomach and intestine such as acid reflux and some other stomach conditions associated with excessive acid production.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology,
Last updated on 29 Oct 2025 | 03:36 PM (IST)
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General Information

The content is shown in English
Enapraz Injection image
Enapraz Injection image

Product introduction

Enapraz Injection is also used to prevent stress ulcers in seriously ill patients and is administered before anesthetic medication to help prevent aspiration-related complications. It belongs to a class of medicines known as proton pump inhibitors (PPIs). This medicine is administered into a vein by a healthcare professional and will only be given to you if your doctor thinks that an injection is more suitable for you at the moment than a tablet. The dose will depend on your underlying condition and how you respond to the medicine. Additionally, your doctor will decide the duration of treatment. You can increase the efficiency of the treatment by eating smaller meals more often and avoiding caffeinated drinks (like tea and coffee), and spicy or fatty foods.

The most common side effects observed with this medicine include injection site reactions, nausea, headache, dizziness, flatulence, diarrhea, stomach pain, and fundic gland polyps. These symptoms are generally mild but if they bother you or do not go away, consult your doctor. Talk to your doctor about ways to prevent bone loss (osteoporosis), like taking calcium and vitamin D supplements.

Enapraz Injection is not suitable for some people. Before receiving this injection, you need to tell your doctor if you have severe liver problems, are taking medicines for HIV, have ever had an allergic reaction to similar medicines in the past, or suffer from bone loss (osteoporosis). Pregnant or breastfeeding women should also consult their doctor. Avoid drinking alcohol as it can make your stomach produce excessive acid and may worsen your symptoms.

Uses of Enapraz Injection

Benefits of Enapraz Injection

Acidity
Acidity is a common condition where excess stomach acid causes a burning sensation in the chest (heartburn), bloating, and discomfort. Enapraz Injection helps by reducing acid production in the stomach, relieving symptoms, and promoting better digestion and comfort.
Gastroesophageal reflux disease (Acid reflux)
Gastroesophageal reflux disease (GERD) is a chronic condition where stomach acid frequently flows back into the food pipe, leading to symptoms like persistent heartburn, regurgitation, and throat irritation. Enapraz Injection helps by lowering acid levels, protecting the esophagus from damage, and reducing the chances of complications like inflammation or ulcers.
Peptic ulcer disease
Peptic ulcer disease occurs when open sores form in the stomach or upper small intestine lining, often due to acid damage. Enapraz Injection reduces stomach acid, allowing ulcers to heal effectively, relieving pain, and preventing recurrence or bleeding.

Side effects of Enapraz Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Enapraz
  • Diarrhea
  • Abdominal pain
  • Headache
  • Flatulence
  • Vomiting
  • Injection site reaction
  • Nausea
  • Fundic gland polyps

How to use Enapraz Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Enapraz Injection works

Enapraz Injection is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.

Quick tips

  • Enapraz Injection is administered as an injection into a vein by a doctor or a nurse.
  • Inform your doctor right away if you develop watery diarrhea, stomach pain, or fever that does not go away, as these could be signs of a serious intestinal infection.
  • Long-term or high-dose use of Enapraz Injection may increase the risk of weak bones (osteoporosis) and low levels of minerals such as magnesium and vitamin B12. Your doctor may advise calcium and magnesium supplements or regular blood tests if prolonged therapy is needed.
  • Consult your doctor immediately if you notice swelling (edema), reduced urination, lower back pain, fatigue, rash, or fever, as these could be signs of a kidney-related problem.
  • Tell your doctor if you are taking atazanavir, clopidogrel, or methotrexate, or if you have a history of liver disease, as dose adjustment or monitoring may be required.

Safety advice

Alcohol

Alcohol

CAUTION
Caution is advised when consuming alcohol with Enapraz Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Enapraz Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Enapraz Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Enapraz Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney

Kidney

CAUTION
Enapraz Injection should be used with caution in patients with severe kidney disease. Dose adjustment of Enapraz Injection may be needed. Please consult your doctor.
Dose adjustment is not required in patients with mild to moderate kidney disease.
Liver

Liver

CAUTION
Enapraz Injection should be used with caution in patients with severe liver disease. Dose adjustment of Enapraz Injection may be needed. Please consult your doctor.
Dose adjustment is not required in patients with mild to moderate liver disease.

Interaction with drugs

Taking Enapraz with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Erlotinib (Oral Route)

Do not consume Erlotinib with Esomeprazole. Esomeprazole may reduce blood levels of Erlotinib.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.

Frequently asked questions

Yes, you can take antacids along with Enapraz Injection. Take it 2 hours before or after you receive Enapraz Injection.
Enapraz Injection is best taken 1 hour before a meal. You should avoid spicy and fatty foods while taking this medicine. You must refrain from caffeinated drinks such as tea, coffee, and cola. Alcohol intake should also be avoided as it may worsen your symptoms.
Yes, it is safe to take painkillers along with Enapraz Injection. Enapraz Injection prevents acidity and stomach ulcers associated with the intake of painkillers. Enapraz Injection is taken 1 hour before a meal. On the other hand, painkillers are usually taken with, or after a meal to avoid stomach upset.
Usually, Enapraz Injection is taken once a day, first thing in the morning. If you take Enapraz Injection twice a day, take 1 dose in the morning and 1 dose in the evening. The tablets should be swallowed whole (remember not be chewed or crushed) and taken at least 1 hour before a meal with some water.
Yes, you can take antacids along with Enapraz Injection. Take it 2 hours before or after you take Enapraz Injection.
Yes, Enapraz Injection can be safely taken with domperidone as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Domperidone works by increasing the gut motility and Enapraz Injection decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.
Enapraz Injection is usually prescribed for short term use only. However, if need arises, such as for treating peptic ulcer disease and Zollinger Ellison syndrome (ZES), Enapraz Injection may be prescribed for a long term duration as well. Long term use may carry an increased risk for side effects and must be discussed with the doctor. Please use Enapraz Injection as advised by your doctor and under their supervision.
If you have been taking Enapraz Injection for a long time, stopping it abruptly may lead to increased acid production, thereby worsening your symptoms. Therefore, you must discuss any dose changes or if you wish to come off Enapraz Injection.
Weight gain is reported in less than 1% of the patients taking Enapraz Injection but the exact cause is unknown. One possible explanation is higher food intake once the reflux symptoms are relieved. Lifestyle modifications such as proper diet and exercise can help to prevent weight gain.
Yes, Enapraz Injection is relatively safe to use. Most of the people who take Enapraz Injection do not get a side effect. It is advised to be taken as directed by the doctor for maximum benefit.
If Enapraz Injection is used for more than 3 months, certain long term side effects may be seen. The most important of these is low magnesium levels in your blood which may make you feel tired, confused, dizzy, shaky or dizzy. You may also have muscle twitches or irregular heartbeat. If the use is further prolonged for more than a year, you may have an increased risk of bone fractures, stomach infections and vitamin B12 deficiency. Vitamin B12 deficiency can make you anemic, as a result of which you may feel more tired, weak, or pale. Additionally you may have palpitations, shortness of breath, lightheadedness, indigestion, loss of appetite, flatulence (gas) or nerve problems such as numbness, tingling and problem in walking.
Yes, Enapraz Injection can be taken with ranitidine. According to research reports, there are no significant interactions seen between Enapraz Injection and ranitidine. However, you must take them together only if prescribed by the doctor.
No, alcohol intake is not advised with Enapraz Injection. Alcohol itself does not affect the working of Enapraz Injection, but it can increase the acid production. This may further cause worsening of your symptoms

Fact Box

Chemical Class

Sulfinylbenzimidazole Derivative

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

Action Class

Proton-Pump Inhibitors
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Incepta Pharma
Address: Parshvnath Tower, Subhash Chowk, Mem Nagar, Ahmedabad-302002 (Gujarat)

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Enapraz Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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