Information about Esomeprazole

Esomeprazole Uses

Esomeprazole is used in the treatment of gastroesophageal reflux disease (acid reflux) and peptic ulcer disease.

How Esomeprazole works

Esomeprazole is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.

Common side effects of Esomeprazole

Headache, Nausea, Abdominal pain, Flatulence, Diarrhea, Vomiting
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MD (Pharmacology), MBBS
Last updated
13 Jun 2023 | 11:29 AM (UTC)

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Available Medicine for Esomeprazole

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Expert advice for Esomeprazole

  • It is a well-tolerated medicine and provides relief for a long time.
  • Some healthy tips to prevent acidity from happening:
    • Avoid excessive intake of carbonated beverages/soft drinks, citrus juices, fried food, caffeinated beverages like tea and coffee.
    • Avoid alcohol and smoking.
    • Avoid eating late at night or before bedtime.
  • Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away.
  • Long-term use of Esomeprazole can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.
  • Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem.

Frequently asked questions for Esomeprazole


Q. What is the best time to take Esomeprazole?

Usually, Esomeprazole is taken once a day, first thing in the morning. If you take Esomeprazole twice a day, take 1 dose in the morning and 1 dose in the evening. The tablets should be swallowed whole (remember not be chewed or crushed) and taken at least 1 hour before a meal with some water.

Q. Can I take antacids along with Esomeprazole?

Yes, you can take antacids along with Esomeprazole. Take it 2 hours before or after you take Esomeprazole.

Q. Can I take Esomeprazole with domperidone?

Yes, Esomeprazole can be safely taken with domperidone as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Domperidone works by increasing the gut motility and Esomeprazole decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.

Q. Can I take Esomeprazole for a long term?

Esomeprazole is usually prescribed for short term use only. However, if need arises, such as for treating peptic ulcer disease and Zollinger Ellison syndrome (ZES), Esomeprazole may be prescribed for a long term duration as well. Long term use may carry an increased risk for side effects and must be discussed with the doctor. Please use Esomeprazole as advised by your doctor and under their supervision.

Q. Can I stop taking Esomeprazole if I feel better?

If you have been taking Esomeprazole for a long time, stopping it abruptly may lead to increased acid production, thereby worsening your symptoms. Therefore, you must discuss any dose changes or if you wish to come off Esomeprazole.

Q. Can Esomeprazole cause weight gain?

Weight gain is reported in less than 1% of the patients taking Esomeprazole but the exact cause is unknown. One possible explanation is higher food intake once the reflux symptoms are relieved. Lifestyle modifications such as proper diet and exercise can help to prevent weight gain.

Q. Is Esomeprazole safe to use?

Yes, Esomeprazole is relatively safe to use. Most of the people who take Esomeprazole do not get a side effect. It is advised to be taken as directed by the doctor for maximum benefit.

Q. What are the long term side effects of Esomeprazole?

If Esomeprazole is used for more than 3 months, certain long term side effects may be seen. The most important of these is low magnesium levels in your blood which may make you feel tired, confused, dizzy, shaky or dizzy. You may also have muscle twitches or irregular heartbeat. If the use is further prolonged for more than a year, you may have an increased risk of bone fractures, stomach infections and vitamin B12 deficiency. Vitamin B12 deficiency can make you anemic, as a result of which you may feel more tired, weak, or pale. Additionally you may have palpitations, shortness of breath, lightheadedness, indigestion, loss of appetite, flatulence (gas) or nerve problems such as numbness, tingling and problem in walking.

Q. Can I take Esomeprazole with ranitidine?

Yes, Esomeprazole can be taken with ranitidine. According to research reports, there are no significant interactions seen between Esomeprazole and ranitidine. However, you must take them together only if prescribed by the doctor.

Q. Can I take alcohol with Esomeprazole?

No, alcohol intake is not advised with Esomeprazole. Alcohol itself does not affect the working of Esomeprazole, but it can increase the acid production. This may further cause worsening of your symptoms


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