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Composition for E 2

Estradiol Topical(0.06%)

food interaction for E 2

alcohol interaction for E 2

pregnancy interaction for E 2

lactation interaction for E 2

It can be taken with or without food, but it is better to take it at a fixed time.
Interaction with alcohol is unknown. Please consult your doctor.
It is highly unsafe to use during pregnancy.
Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.
It is probably safe to use during breastfeeding. Please consult your doctor.


Estradiol Topical(0.06%)


E 2 0.06% gel is used as a hormone replacement therapy (HRT) in post-menopausal women or women with absent ovaries or when ovaries are unable to produce enough estrogen.

How it works

Estradiol belongs to a class of medications called as sex hormones. It is a form of estrogen (female sex hormone) that is produced by the ovaries. It acts by replacing the natural hormone in the body when there is a deficiency.

Common side effects

Vomiting, Nausea, Application site irritation, Breast discomfort, Breast pain, Abdominal bloating, Hair loss, Headache, Stomach cramp, Vaginal bleeding, Vaginal itching, Vaginal discharge


No substitutes found

Expert advice for E 2

  • Do not use estradiol patches over your breasts.
  • Tell your doctor if you have ever had any of the following problems, before you start the treatment:
  • fibroids inside your womb, growth of womb lining outside your womb (endometriosis) or a history of endometrial hyperplasia (excessive growth of the womb lining), family history of breast cancer.
  • Stop taking estradiol and see a doctor immediately if you notice yellowing of your skin or the whites of your eyes (jaundice), rise in your blood pressure (symptoms may be headache, tiredness, dizziness), new onset migraine-like headaches, pregnancy, signs of a blood clot, such as: painful swelling and redness of the legs, sudden chest pain, difficulty in breathing.
  • Do not use if you are allergic to estradiol hemihydrate or any of its ingredients.
  • Do not use if you have or have ever had breast cancer or cancer of the womb lining (endometrium). 
  • Do not use if you have excessive thickening of the womb lining (endometrial hyperplasia).
  • Do not use if you have unexplained vaginal bleeding.
  • Do not use if you have venous thromboembolism or other thrombophilic disorders.
  • Do not use if you have a rare blood problem called porphyria.
  • Do not use by Pregnant and breastfeeding women.
  • Do not use by Children.

Frequently asked questions for E 2

Estradiol Topical

Q. Is estradiol and estrogen the same/ is estradiol the same as progesterone/ is estradiol a synthetic hormone/does estradiol valerate work/ what is evalon cream? 
Estradiol is the most potent natural estrogen produced by ovaries in female. It is different from another female hormone that is progesterone. It is not a conjugated estrogen and it not a synthetic hormone. Estradiol valerate and Evalon vaginal cream works same as estradiol.
Q. Can I take estrogen forever? 
Always follow the instructions of doctor regarding the dosage and duration.
Q. Is estradiol safe/ stop your period?
Estradiol is safe if used at recommended dosage and duration. Estradiol can stop your periods. Other side effects are not confirmed but may occur with some patients. Consult your doctor if you experience any side effects.
Q. Is estradiol a conjugated estrogen/ better than Premarin?
Estradiol is a synthetic hormone, whereas premarin contains conjugated estrogen. Both are different types of estrogen and have comparable benefit and side-effect profile.


Content on this page was last updated on 09 January, 2016, by Dr. Varun Gupta (MD Pharmacology)