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Durogesic 25mcg Patch

Written By Dr. Subita Alagh, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 19 Sep 2025 | 03:31 PM (IST)
Durogesic 25mcg Patch is a pain-relieving medicine. It is used to manage persistent, moderate to severe chronic pain that requires continuous, around-the-clock opioid administration for an extended period of time.
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General Information

Contains

Fentanyl (25mcg)

Marketer

Janssen Pharmaceuticals

Storage

Store below 30°C
The content is shown in English
Durogesic 25mcg Patch image
Durogesic 25mcg Patch image

Product introduction

Your doctor will explain how to use Durogesic 25mcg Patch. Follow the instructions carefully to get the most benefit. The dose and duration will depend on what you are using it for and how well it helps your symptoms. Use it regularly and do not discontinue using it until the doctor tells you it is alright to stop.

The most common side effects of this medicine include headache, dizziness, vomiting, nausea, abdominal pain, and irregular heartbeat. You may have side effects more often when you start your treatment or when your dose is increased. Usually, the side effects will slowly go away as your body gets used to it. If they are severe or do not go away, you should remove your patch and contact your doctor.

Before using the medicine, you should tell your doctor if you have any other illnesses or disorders. It may also affect, or be affected by, some other drugs you are using so let your doctor know what these are to be safe. Pregnant and breastfeeding women should consult their doctors first before using the medicine.

Uses of Durogesic Transdermal Patch

  • Severe chronic pain

Benefits of Durogesic Transdermal Patch

Severe chronic pain
Durogesic 25mcg Patch helps to relieve chronic pain in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis. Applying it will help you go about your daily life more easily. This will help you to go about your daily activities more easily and have a better, more active, quality of life. Consult a doctor if you are not sure.

Side effects of Durogesic Transdermal Patch

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Durogesic
  • Abdominal pain
  • Dizziness
  • Vomiting
  • Nausea
  • Drowsiness
  • Application site redness
  • Respiratory depression
  • Rigidity

How to use Durogesic Transdermal Patch

Use this medicine in dose and duration as advised by your doctor. Check the label before use. Make sure the skin is clean and dry. Remove the protective liner of the patch. Do not touch the sticky side. With sticky side down, place the patch evenly onto the skin.

How Durogesic Transdermal Patch works

Durogesic 25mcg Patch is an opioid analgesic (pain reliever) that works by blocking the transmission of pain signals to the brain to lower pain perception.

Quick tips

  • Always apply Durogesic 25mcg Patch to clean, dry, and non-irritated skin, preferably on the upper arm, chest, or back.
  • Avoid exposing the patch to direct heat (like heating pads or hot baths), as it can increase medicine absorption and overdose risk.
  • Never cut or trim Durogesic 25mcg Patch while applying as it can change how the medicine from Durogesic 25mcg Patch releases and increase the risk of serious side effects.
  • Rotate the Durogesic 25mcg Patch site with each new application to prevent skin irritation.
  • After removal, fold the Durogesic 25mcg Patch in half (sticky sides together) and safely discard it to keep it away from children or pets.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Durogesic 25mcg Patch may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Durogesic 25mcg Patch is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Consult a doctor immediately if the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing problems, or limpness.
Driving

Driving

No interaction found/established
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited information available on the use of Durogesic 25mcg Patch in patients with kidney disease. Please consult your doctor.
Caution should be excercised in patients with underlying kidney disease.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited information available on the use of Durogesic 25mcg Patch in patients with liver disease. Please consult your doctor.

Interaction with drugs

Taking Durogesic with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Selegiline (Oral Route)

Do not consume Selegiline with Fentanyl. If essential, watch out for symptoms such as fever, tremors, diarrhea or agitation. Please consult your doctor.
Life-threatening

Naltrexone (Oral Route)

Do not consume Naltrexone with Fentanyl; watch out for symptoms such as breathlessness, increased heart rate, or headache. Naltrexone may reduce efficacy of Fentanyl.
Life-threatening

Tranylcypromine (Oral Route)

Do not consume Tranylcypromine with Fentanyl. If Tranylcypromine is essential, ensure a gap of At least 2 weeks between taking Tranylcypromine and Fentanyl. Please consult your doctor.
Severe

Ziprasidone (Oral Route)

Watch out for symptoms such as tremors, fever, diarrhea or agitation and consult your doctor if you experience them. Your doctor may discontinue the medicines accordingly.
Severe

Alprazolam (Oral Route)

If concurrent use is essential, watch out for symptoms of Alprazolam side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Alprazolam as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.

Frequently asked questions

Durogesic 25mcg Patch may cause drowsiness and dizziness, especially in the beginning of the treatment. Do not drive or work with tools or machinery if your alertness is affected. It is not advisable to drink alcohol during treatment with this medicine as it might increase sleepiness.

Fact Box

Chemical Class

Phenylpiperidine Derivatives

Habit Forming

Yes

Therapeutic Class

PAIN ANALGESICS

Action Class

Opioids

References

  1. Schumacher MA, Basbaum AI, Way WL. Opioids Analgesics & Antagonists. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 545-46.
  2. Yaksh TL, WallaceIn MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 505-506.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 539-41.
  4. Fentanyl. Gloucester Business Park Gloucester: Hameln Pharmaceuticals Ltd.; 10 Jan. 2011 [revised 28 Oct. 2018]. [Accessed 02 Apr. 2019] (online) Available from:
  5. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 02 Apr. 2019] (online) Available from:
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:
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User feedback

Once A Day
67%
Alternate Day
17%
Twice A Week
8%
Once A Week
8%
Excellent
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Poor
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With or without food
100%
Expensive
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Average
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Janssen Pharmaceuticals
Address: Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060

Vendor Details

Country of origin: India

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