Dupox Gel

SALT COMPOSITION
Storage
Store at room temperature (10-30°C)

Introduction

Dupox Gel is a pain relieving medicine. It is applied topically to treat moderate to severe pain. It helps relieve pain and swelling or various joints and muscles.

Dupox Gel is only meant for external use and should be used strictly as advised by your doctor. A thin layer of the medicine should be massaged into the affected areas with clean and dry hands. Avoid getting in contact with your eyes, nose, or mouth. In case of accidental contact, you should rinse it thoroughly with plenty of water.

It is usually safe with little or no side effects. However, it may cause burning sensation and skin irritation at the site of application. They are usually temporary and resolve with time. If they do not get better with time or worsen, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.

Before using the medicine, it is important to tell your doctor if you are using or have recently used any other medicines for the same disease or other diseases. To make sure the medicine is safe, pregnant and breastfeeding women should consult their doctor before using the medicine.

Uses of Dupox Gel

Benefits of Dupox Gel

In Pain relief

Dupox Gel is used to relieve pain, inflammation, and swelling in painful conditions that affect joints and muscles. It is very effective in treating strains, sprains, backache, and sports injuries. It is also helpful for pain caused by tendonitis (such as tennis elbow). Applying it will help you go about your daily life more easily. If the injury is severe or lasts a long time, you may also need to take painkillers or you can even consider physiotherapy. Consult a doctor if you are not sure.

Side effects of Dupox Gel

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Dupox

  • No common side effects seen

How to use Dupox Gel

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.

How Dupox Gel works

Dupox Gel is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that are responsible for inflammation (pain and swelling).

Safety Advice

Alcohol
No interaction found/established
Pregnancy
CONSULT YOUR DOCTOR
Dupox Gel may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
SAFE IF PRESCRIBED
Dupox Gel is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
The baby's skin should not come into direct contact with the treated area of skin. Water-miscible cream/gel is preferred as ointments may expose the baby to harmful effects of Dupox Gel via licking.
Driving
No interaction found/established
Kidney
No interaction found/established
Liver
No interaction found/established

What if you forget to take Dupox Gel?

If you miss a dose of Dupox Gel, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Dupox Gel
₹40.0/Gel
Piricam Gel
Zydus Cadila
₹27/Gel
save 32%
Pirox Gel
Cipla Ltd
₹41.31/Gel
3% costlier
Pirox Gel
Cipla Ltd
₹67.5/Gel
69% costlier
Dolonex Gel
Pfizer Ltd
₹79.75/Gel
99% costlier
4-Steps Gel
Aeran Lab India Pvt Ltd
₹95.23/Gel
138% costlier

Quick Tips

  • Dupox Gel helps relieve pain and swelling of various joints and muscles.
  • Rub it gently over the affected area, until it is absorbed.
  • Do not apply to broken, diseased, infected or irritated skin, or to open wounds.
  • Do not cover the area being treated with airtight dressings such as bandages, as these may increase the risk of side effects.
  • Avoid contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get the gel in these areas.
  • Stop using Dupox Gel and immediately inform your doctor if you notice skin rashes, sores, blisters or ulcers in the mouth, nose, throat or genitals.
  • Do not use it for longer than four weeks without talking to to your doctor first.

Fact Box

Chemical Class
Enolic acid Derivatives
Habit Forming
No
Therapeutic Class
PAIN ANALGESICS

Interaction with Drugs

Taking Dupox with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Nimsun, Abinim, Nimulis
LIFE-THREATENING
Brand(s): Oxy Triactin, Sioril
LIFE-THREATENING
Brand(s): Pyregin, Alpagin, Novalgin RC
LIFE-THREATENING

Patient Concerns

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One of my teeth is sensitive. It some times pains
Dr. Abhijit Gambhir
Dental Surgery
sensitivity has many causative factors for relief of pain you can take pain killers it will give temporary relief
fever and 2 months pregnant can take combiflan
Dr. Sonu Balhara Ahlawat
Obstetrics and Gynaecology
No take Crocin for pain relief
arrow
Do you have any questions related to Dupox Gel ?

FAQs

Q. What is the difference between Dupox Gel and diclofenac?

Both Dupox Gel and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Dupox Gel.

Q. What is the difference between Dupox Gel and naproxen?

Both Dupox Gel and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Dupox Gel.

Q. What is the difference between Dupox Gel and meloxicam?

Both Dupox Gel and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Dupox Gel.

Q. What is the difference between Dupox Gel and ketoprofen?

Both Dupox Gel and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Dupox Gel. Ketoprofen gel also showed excellent tolerability.

Q. What is the difference between Dupox Gel and tramadol?

Dupox Gel is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.

Q. What is the difference between Dupox Gel and nimesulide?

Both Dupox Gel and nimesulide are pain killers. However, Dupox Gel is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.

Q. Can Dupox Gel be used in the treatment of chikungunya?

Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Dupox Gel or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Dupox Gel.

Q. Are Dupox Gel and aspirin same?

No. Dupox Gel and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.

Q. Can Dupox Gel be used along with dexamethasone?

No. Dupox Gel should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.

Q. Can Dupox Gel be used with methocarbamol?

Yes. Methocarbamol can be used with Dupox Gel as no serious side effects are known. Inform your doctor before starting any of the medication.

Q. Can Dupox Gel be used along with paracetamol?

Yes. Paracetamol can be used with Dupox Gel as no serious side effects are known. Inform your doctor before starting any of the medication.

Q. Is Dupox Gel a NSAID?

Yes. Dupox Gel is a non-steroidal anti-inflammatory drug (NSAID).

Q. Is Dupox Gel a sulfa drug?

Dupox Gel is a sulphur containing compound. Dupox Gel can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.

Q. Is Dupox Gel a blood thinner?

No. Dupox Gel is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.

Q. Is Dupox Gel a muscle relaxant?

No. Dupox Gel is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.

Q. Is Dupox Gel a narcotic?

No. Dupox Gel is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.

Q. Can Dupox Gel be used in hypertension?

No. Dupox Gel is not a medication to control hypertension. It is important to note that Dupox Gel decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Dupox Gel.

Q. Can Dupox Gel be used along with Losartan?

No. Dupox Gel should not be combined with Losartan. It is important to note that Dupox Gel decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Dupox Gel.

Q. Can Dupox Gel be used with Lisinopril?

No. Dupox Gel should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Dupox Gel.

Q. Can Dupox Gel be used with calcium channel blocker?

Yes. Dupox Gel can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)

Q. Can Dupox Gel be used with Tizanidine?

Yes, Dupox Gel can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.

Q. Why is beta cyclodextrin added to Dupox Gel?

Yes. Dupox Gel can be combined with beta-cyclodextrin. Research has shown that combining Dupox Gel with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.

Q. Are there any alternatives of Dupox Gel?

Yes. There are alternatives to Dupox Gel. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.

Q. What are the contraindications for Dupox Gel?

Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.

Q. Can Dupox Gel be used in the treatment of allergy?

No. Dupox Gel is not a drug to treat allergy. It is a pain killer.

Q. How long does Dupox Gel work?

Dupox Gel is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.

Q. Can you get high by using Dupox Gel?

No. Dupox Gel is not known to cause high. It is a non-narcotic painkiller.

Q. Can Dupox Gel be used to treat menstrual cramp?

Dupox Gel is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.

Q. Can I use Dupox Gel for a migraine?

Dupox Gel is not approved for the treatment of migraine. Research studies have shown that Dupox Gel is effective in significantly decreasing the pain associated with migraine without aura.

Q. Is Dupox Gel effective in back pain management?

Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Dupox Gel as the cause of back pain can be different for different person.

Q. Is Dupox Gel affective in gout management?

Yes. Dupox Gel can be given for the treatment of acute gout. Research studies have shown Dupox Gel to be highly effective in the treatment of acute gout.

Q. Can you donate blood when on the medication with Dupox Gel?

Yes. You can donate blood when on Dupox Gel. Do inform your doctor before donating blood.

Q. Can I use Dupox Gel if I am a diabetic?

Dupox Gel in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Dupox Gel so taking piroxicam can lead to increased risk of renal failure by many folds.

Q. Can I use Dupox Gel if I have a deranged renal function?

No. Dupox Gel should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.

Q. Can Dupox Gel lead to skin reactions?

Yes. Dupox Gel is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.

Q. Can I use Dupox Gel if I am pregnant?

No. Dupox Gel should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.

Q. Can I use Dupox Gel if I have peptic ulcer disease?

No. Dupox Gel is contraindicated in cases of active peptic ulcer disease. Dupox Gel is known to cause gastric ulceration and bleeding.

Q. Can I use Dupox Gel if I have asthma?

Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.

Q. Can Dupox Gel lead to difficulty in conception?

Yes. Dupox Gel can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.

Q. Can Dupox Gel be used with diuretics?

No. Dupox Gel should not be used with diuretics. Dupox Gel reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.

Q. Can Dupox Gel be used with lithium?

No. Dupox Gel should not be used with lithium. Dupox Gel leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.

Q. Can Dupox Gel be used with warfarin?

No. Dupox Gel should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.

Q. What increases the chances of getting a gastric ulcer when I am already taking Dupox Gel?

The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.

Q. Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Dupox Gel?

Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.

Q. What are the serious side effects of Dupox Gel?

GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 628.
  2. Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 989-90.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1127-28.
  4. PubChem. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:External Link
  5. ScienceDirect. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

6th Floor, “B” Wing, Manubhai Towers,Sayajigunj, Vadodara - 390005 Gujarat. India
Country of Origin: India

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