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Duleve 40 mg Capsule

Zydus Cadila

Composition for Duleve 40 mg Capsule

Prescription Required

Primary uses of Duleve 40 mg Capsule

Potentiallyunsafewith
Alcohol
MRP
72.11
₹7.21/Capsule
10 capsules in 1 strip
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Medicine Overview of Duleve Capsule

Uses of Duleve Capsule

Duleve 40 mg Capsule is used in the treatment of depression, anxiety disorder, diabetic nerve pain, fibromyalgia, neuropathic pain and stress urinary incontinence.

Duleve Capsule side effects

Common

Side Effects of Duleve are Nausea, Headache, Dryness in mouth, Sleepiness, Dizziness.

How to use Duleve Capsule

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Duleve 40 mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Duleve Capsule works

Duleve 40 mg Capsule works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.

In Depth Information on Duleve Capsule

Expert advice for Duleve Capsule

  • You may have to wait for 2 to 4 weeks to get the full effect.
  • If your doctor asks you to stop Duleve 40 mg Capsule, you should not discontinue it abruptly. Many patients tolerate decreasing 50% dose every 3 days however if the withdrawal symptoms emerge during tapering it would require more gradual tapering over few weeks.
  • Inform your doctor if you have ever been diagnosed with any heart problems (heart attack, heart failure, slow or irregular heart rate).
  • Inform your doctor if you have ever been diagnosed with kidney or liver problems.
  • It can cause a sensation of restlessness or an inability to sit or stand still. This is most likely to occur within the first few weeks of treatment. You should tell your doctor if this happens to you.
  • It may be more effective in some patients with depression who fails to respond to selective serotonin receptor inhibitors (SSRI) e.g. Fluoxetine.
  • Monitor blood pressure (BP) frequently.
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Duleve Capsule related warnings
Special precautions for Duleve Capsule
Alcohol
CAUTION
Duleve 40 mg Capsule may cause excessive drowsiness and calmness with alcohol.
Pregnancy
WEIGH RISKS VS BENEFITS
Duleve 40 mg Capsule may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Lactation
CAUTION
Duleve 40 mg Capsule is probably unsafe to use during lactation. Limited human data suggest that the drug could represent a significant risk to the baby.
Driving
Duleve 40 mg Capsule may make you feel dizzy, sleepy, tired, or decrease alertness. If this happens, do not drive.
Kidney
Duleve 40 mg Capsule should be used with caution in patients with severe kidney disease. Dose adjustment of Duleve 40 mg Capsule may be needed. Please consult your doctor.
Dose adjustment is not recommended in patients with mild and moderate kidney disease.
Liver
UNSAFE
Duleve 40 mg Capsule is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

What if you miss a dose of Duleve Capsule?uses

If you miss a dose of Duleve 40 mg Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Patient Concerns

Questions Related to Duleve
sir, my self im very depressing while comparing me to others& i dont talk to much bcoz i feel im not in level to talk with them & feel me about myself everyday about my negetativity.this type thinking stressess me very much how can i come from this type of stress?? i feel this is b.coz my weight & height at the age of 21 im right sir??
Dr. Jyoti Kapoor Madan
Psychiatrist
If you let your confidence down, you will develop helplessness ehic leads to depression. Instead of worrying about your weight, take action. Seek professional help. If you feel unmotivated, meet a psychiatrist, its neither too early nor too late for professional advice.
Sir i m suffering from mindly disturbance last 8 days because i have fail in love . Now i dont get to sleep. Only 2-3 hrs sleeping please help me. Im in more depression
Dr. Mehtab Baig
Physiotherapist
Think one mantra ,,,,,duniya jaye bhad me ,,,,, if u don't you takes always on medicine plz ignore all your memories with your ex And deleted
Doctor i m suffering from a major depression disoder i went to a psychiatrist 2 days back she prescribed tab paxidep cr 25mg, lithosun 300mg along with epitril 1mg for sleep purpose but still i m not getting sleep could you let me know that what is my rootcause & i would be on balance
Dr. Varun Mehta
Psychiatrist
Dear PATIENT are many causes of depression ranging from genetics to socialDifficulty in falling asleep is one of the symptoms of depressionThe medications take time to act and you should wait for atleast 7-10 days for observable effect to take place
I m in depression as I m not getting any job. Parents r forcing me for marriage bt i want to do something in my life nd now I m feeling like hell. What to do?
Dr. Jyoti Kapoor Madan
Psychiatrist
Dealing with Depression- Assess your thinking pattern. Become aware of negative thought patterns. Decide to trash negative thoughts and replace them by positive thoughts. Pursue hobbies that make you happy. Manage time by making a schedule that includes physical exercises and De stress routines. Communicate your thoughts to people you are comfortable with. Accept your limitations and work on them if possible, no one is born perfect and we don't need to be perfect, we need to be adaptive.
Diet control iam suffering from dipression and blood prassur
Dr. Waseem Mirza
Sexologist
Diet has no major role in depression. Just take your anti depressant medications regularly and follow up with your doctor periodically as advisedFor high bp, Take salt restricted diet, Avoid fatty foods. Walk daily for 30 mins
Hello sir i have taking the tablet of depression from three month this desease come out from dengue now i have taking ventab 25 mg proponol 10 mg and clozepam . 50mg but when i get off it again i feel anxient and sad. I feel freqeunt in mind only when i miss one or two days dose. I wanted to know that we will i stop these medicine i also wanted to get pregnant but due to this tablets i miss this chance sir please help me when will i conceive because have no baby and wanted to plan for this
Dr. Sunil Sekhri
Diabetes Specialist
you have been diagnosed with depression as told by you. It is a treatable condition. your re already undergoing medical therapy and you consult your Doctor to add Psychotherapy but this decision has to be made by your treating doctor
I feel like tired and not Intrested in work if I go to work my mind won't be constant it swings itseems like all new my heart beat get faster feel like difficult to breath
Dr. Ambrish Dharmadhikari
Mental Wellness
It seems you might be suffering from depression. Please search internet for self help CBT" and use those techniques for your help. Along with this please continue medications and follow up regularly with your psychiatrist."

Frequently asked questions about Duleve Capsule

Frequently asked questions about Duloxetine

Q. Is Duleve a non-steroidal anti-inflammatory drug (NSAID)?
No. Duleve is not a non-steroidal anti-inflammatory drug (NSAID). It belongs to the anti-depressant class of drugs, more specifically SNRI (Serotonin-Norepinephrine Reuptake Inhibitor). It works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the nervous system.
Q. Is Duleve a steroid?
No. Duleve is not a steroid. It belongs to the anti-depressant class of drugs, more specifically SNRI (Serotonin-Norepinephrine Reuptake Inhibitor). It works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the nervous system.
Q. Is Duleve a blood thinner?
No. Duleve is not a blood thinner. Blood thinners prevent the formation of harmful blood clots.
Q. Is Duleve a stimulant?
No. Duleve is not a stimulant. Stimulants are the medicines which activate the central nervous system.
Q. Is Duleve a pain killer?
No. Duleve is not a classical painkiller e.g. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).Duloxetine is used for the treatment of chronic pain conditions like neuropathic pain, diabetic neuropathy or fibromyalgia.
Q. Is Duleve a tricyclic antidepressant (TCA)?
No. Duleve is not a tricyclic antidepressant (TCA). It belongs to a class of anti-depressants called SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors).
Q. Is Duleve a benzodiazepine?
No. Duleve is not a benzodiazepine. It belongs to a class of anti-depressants called SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors). Benzodiazepines belong to the sedative-hypnotic class of drugs and include agents like diazepam, lorazepam, alprazolam etc.
Q. Is Duleve a narcotic?
No. Duleve is not a narcotic. It means it does not have habit-forming potential. Narcotics are the substance which can cause addiction and dependence.
Q. Is Duleve a psychotropic?
Yes. A psychotropic is a medicine that affects mind, emotions, and behaviour. Duleve, being an anti-depressant agent reduces the symptoms of depression and is a psychotropic agent.
Q. Can I take Duleve if I have Hepatitis C virus infection?
Duleve should be used with caution in patients with Hepatitis C virus infection. Cases of liver injury, including severe elevations of liver enzymes (>10-times upper limit of normal), hepatitis, and jaundice have been reported with Duleve. Taking Duleve increases the risk of liver toxicity and fatty liver in Hepatitis C virus-infected patients.<br>
Q. What is the peak plasma concentration [Cmax] of Duleve?
The maximum plasma concentration [Cmax] of Duleve is 6 hours post oral dose. Food taken with Duleve may delay the time to reach the peak plasma concentration from 6 to 10 hours. This may marginally decrease the extent of absorption (approximately 11%).
Q. Can I take Duleve with Vitamin D?
Yes. Dulevecan be taken with vitamin D. It does not have any known interaction with Vitamin D.
Q. What is half life of Duleve?
The elimination half-life of Duleve ranges from 8 to 17 hours (mean 12 hours).
Q. Which is better in depression, Duleve or fluoxetine?
Fluoxetine has not been found to be different in either tolerability or efficacy when compared with Duleve in major depression. Duleve is good for treating depression, anxiety and may help with chronic pain.
Q. Which is better Duleve vs sertraline?
Duleve and sertraline are found to be equally effective in the treatment of Major Depressive Disorder (MDD). Certain symptoms like agitation and anxiety are reduced better by sertraline. Duleve has been found to be better than sertraline for neuropathic pain.
Q. Which is better for chronic pain, Duleve or pregabalin?
In patients with fibromyalgia Duleve is found to be better than pregabalin in reducing depressed mood. Pregabalin is better in reducing fatigue. Duleve and pregabalin generally provide equally comparable pain relieving efficacy in the treatment of diabetic peripheral neuropathic pain (DPNP).
Q. Which is better Duleve or fluoxetine?
Duleve has been found to be better for the treatment of chronic pain than Fluoxetine. Fluoxetine is good for treating depression and anxiety.
Q. Which is better for depression, Duleve or mirtazapine?
Currently, there is not enough information to firmly recommend one antidepressant over another. However, both these drugs have been found to be safe and efficacious in the treatment of depression.
Q. Which is better for depression, Duleve or venlafaxine?
Currently, there is not enough information to firmly recommend one antidepressant over another. Many doctors favour Duleve over venlafaxine when pain conditions coexist with depression.
Q. Is Duleve a barbiturate?
No. Duleve is not a barbiturate. Barbiturates belong to the Sedative-Hypnotic class of drugs and are likely to have abuse potential.
Q. When to take Duleve?
Duleve can cause difficulty in sleep (insomnia). Hence, it is advised to be taken in the morning than at night.
Q. When does Duleve start working?
Usually, the action of Duleve takes about three to four weeks to appear. Do not discontinue the therapy in between, thinking that it is not effective.
Q. How much dose of Duleve can produce overdose?
Overdose can occur at a doses as low as 1000 mg. Signs and symptoms of overdose (duloxetine alone or in combination with other medicinal products) included somnolence, coma, serotonin syndrome, seizures, vomiting and tachycardia.
Q. How does Duleve work in urinary incontinence?
Duleve is thought to work by interfering with certain chemicals (called serotonin and noradrenaline) that are used within the nerves that send messages to your pelvic floor muscles. This helps the muscles around the bladder outlet to contract more strongly, and this in turn controls the flow of urine and helps to prevent any leakage.
Q. Can I take Duleve with amitriptyline?
It is better to avoid Duleve and amitriptyline together. It can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.
Q. Can I take Duleve with sertraline?
It is better to avoid Duleve and sertraline together. It can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.
Q. Can I take Duleve with tramadol?
Duleve and tramadol together can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Please inform your doctor if you are taking any of these medicines before coming to him.
Q. Can I take Duleve with bupropion?
Bupropion can cause inhibition of metabolism of Duleve in the body, resulting in toxic effects of Duloxetine. The concomitant use of these two drugs can result in seizures. Mention it to your doctor if you are taking any of these medications from before.
Q. Which is better in diabetic neuropathy, duloxetine or pregabalin?
In patients with fibromyalgia, Duleve is found to be better than pregabalin in reducing depressed mood. Pregabalin is better in reducing fatigue. Duleve and pregabalin generally provide equally comparable pain relieving efficacy in the treatment of diabetic peripheral neuropathic pain (DPNP).
Q. Can Duleve get me high?
No. Duleve does not cause a high. It does not create a feeling of euphoria and has no recreational potential.
Q. Can I use Duleve for arthritis?
Duleve is not approved for the treatment of arthritis. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.
Q. Can I use Duleve for sciatica?
No, Duleve is not approved for the treatment of sciatica. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.
Q. Can I use Duleve for obsessive-compulsive disorder (OCD)?
Obsessive-compulsive disorder (OCD) is a type anxiety disorder. It is approved for the treatment of obsessive-compulsive disorder. Research studies suggest that Duleve may provide a significant reduction in symptoms for patients with obsessive-compulsive disorder.
Q. Can I use Duleve for hot flashes?
No. Duleve is not approved for use in hot flashes. It may be used in the treatment of depression in postmenopausal women suffering from menopausal vasomotor symptoms (hot flashes, night sweats) and insomnia.
Q. Can I use Duleve for headaches?
No, Duloxetine is not approved for use in headaches. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.
Q. Can I use Duleve for a migraine?
No. Duleve is not approved for use in a migraine. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.
Q. Can I use Duleve for chronic pain?
Duleve is approved for the treatment of chronic pain states including neuropathic pain (nerve pain) associated with Diabetes Mellitus and fibromyalgia.
Q. Can I use Duleve for nerve pain?
Yes. Duleve is approved for use in nerve pain or neuropathic pain conditions, most commonly seen in patients suffering from Diabetes Mellitus.
Q. Can Duleve raise blood sugar levels?
No. Duleve may affect blood sugar levels. If you are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor.

Severely interacts with other drugs like

Taking Duleve with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Duleve with Thioridazine
LIFE-THREATENING
Medicines with composition Thioridazine: R Zin, Zina, Thiolite, T Zine, Thioril, Tridaz, Multizine, Ridazin, Delnil, Thiolent
Duleve with Darunavir
SERIOUS
Medicines with composition Darunavir: Virem
Duleve with Saquinavir
SERIOUS
Medicines with composition Saquinavir: Maximune, Saquin
Duleve with Fluoxetine
SERIOUS
Medicines with composition Fluoxetine: Flotin, Fluxen, Fluty, FT, Depilox, Bydep, Afzot, Ulaxy, Flurix, Tune
Duleve with Citalopram
SERIOUS
Medicines with composition Citalopram: Vocita, Celexa, Olarc, Citopam, Cetadep, Topdep, Celica, Citalomine, Citalent, Citola
Duleve with Indinavir
SERIOUS
Medicines with composition Indinavir: Indivan
Duleve with Flecainide
SERIOUS
Medicines with composition Flecainide: Flecarite
Duleve with Atazanavir
SERIOUS
Medicines with composition Atazanavir: Atazor, Atavir, Virataz
Duleve with Fluvoxamine
SERIOUS
Medicines with composition Fluvoxamine: Boxamine, Voxinix, Fluvox, Uvox, Voxidep, Voxazen, Voxamin, Psyvoxin, Fluxam, Sorest
Duleve with Ritonavir
SERIOUS
Medicines with composition Ritonavir: Viriton, Ritomune, Ritomax, Empetus
Duleve with Paroxetine
SERIOUS
Medicines with composition Paroxetine: Leparox, Prx, Paromec, Madotine, Parolyst, Parox, Baxidep, Psypro, Parot, Proxzen
Duleve with Sertraline
SERIOUS
Medicines with composition Sertraline: Zosert, Sernit, Taline, Biosert, Pifser, Yline, Mares, Serwal, Setalin, Setrakon
Duleve with Escitalopram
SERIOUS
Medicines with composition Escitalopram: Kopram, Ecit, Escnx, Esitopa, Madito, Citolex, Elcit, Escivi, Esetinol, Esmood
Duleve with Lithium
SERIOUS
Medicines with composition Lithium: Psycolith, Cartil, A Lith, Likon, Lidep, Cylith, Elith, Litholite, Lithocent, Lisalt
Duleve with Propafenone
SERIOUS
Medicines with composition Propafenone: Pradil
Duleve with Nelfinavir
SERIOUS
Medicines with composition Nelfinavir: Nel
Duleve with Dapoxetine
SERIOUS
Medicines with composition Dapoxetine: Actinex, DA Sutra, Stay Tal, Dapoxy, Dapnex, Duraject, Appynite, Dejac, Xydap, Dapox
Duleve with Atomoxetine
SERIOUS
Medicines with composition Atomoxetine: Attera, Axepta, Starkid, Tomoxetin, Atokem
One of the following vendor pharmacies will deliver Duleve 40mg Capsule: SVH, PRT, AVS, DVH, AMH, HSM, BAP, KMC, AYN, VRS, KIM, MKT, RUS, NDP, USF, NXG, ALC, LHP, NVL, GEO, DHP, KIS, MDO, UMP, JBT, HSP, IMC, DFP, CMD, BDN, SIO, PLT, WHL, RDH, CLT, NTL, HEX, DLP, ATL, AGT, EQN, RHL, OWN, SDE, QLF, SCH, DPP, WAD, GNC, RTL, 1MH, GGL, PEN, NWP, BHP, LHA, JVO, 9MM, SBA, SBN, HWS, OIP, RPP, HBV, SGH, BLE, SMN, VDH, EEC, RAC, BJP, CRN, DYL, SLN, BNA, KHC, NSL, GLM, DLY, UVD, THP, AHP, NLP, SVS, BRC, SCP, VSL, KHH, CMC, HIP, FRM, SNH, APS, FGH, PMA, WSI, MAX, BHM, ZEL, PRC, PNT, YMI, JIV, CPK, HTS, HCP, SHN, BHS, MSD, GTC, ATP, SBL, PVP, WPL, SHG, SPD, AAY, SSS, SLC, BSL, SWP, NTB, MJT, GBL, PRN, NEO, MKS, HNP, UHP, DGN, MDN, FIP, HAT, DAO, BNC, RWP, ZPR, SHC, VTR, ABP, JSL, GPP, BLP, ANT, VSC, SPF, 4IT, MOM, VOP, MLC, RRP, HZF, WHP, VJS, JHC, RGH, IPP, RHS, BTM, MPC, MDH, HGI, STS, SHD, PPR, HMP, RPI, JJE, PHN, SJP, ANP, AFT, PSF, BDI, BHA, MAP, OMV, SYN, RSA, PTI, ALY, GMA, EVP, PHC, EPS, TOM, BBN, SGC, ZVP, TNH, PTP, RHW, UPA, BBS, PWN, NAS, INC, AYM, OWP, BIO, DZY, GLD, MBP, NPH, SWA, MRS, ENP, BSN, LCC, DRA, ESY, XMX, AVB, LMS, GFL, ARD, AVL, BNT, RSS, STA, BJR, RKS, ASP, IAD, MDI, AYU, KHD, KNH, ANS, MAM, OHM, OLT, GDA, QTM, JVN, NLG, BLS, TSS, RVC, NNP, SSI, IPL, EMB, TFP, RDR, HLT, DPL, HPP, MIP, GHR, SDM, AMR, TAT, HPC, VNS, BAL, TRP, SRG, AAR, SNG, NVY, VHP, DYG, WDE, SAA, MAK, PRL, BGS, SMS, DHR, OBS, ADT, AXM, EAN, SAF, KLC, PNQ, BMJ

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Authored by
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