Donep 5 Tablet is used to treat mild to moderate dementia in Alzheimer’s disease, a progressive illness that gradually affects memory and thinking. It does not cure this illness but may help improve memory, awareness, and other symptoms.

Your doctor will explain how to take Donep 5 Tablet. You may take it with food, preferably at night before going to bed. Follow the instructions carefully to get the most benefit. The dose may change from time to time to suit your individual needs. It can take up to a few weeks for symptoms to improve so keep taking your medicine regularly. You should not stop taking this medicine without consulting your doctor.

Some common side effects of this medicine include nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, weight loss (anorexia), headache, loss of appetite, common cold, urinary incontinence, and rash. Drink plenty of fluids to keep yourself hydrated. You may have side effects more often when you start your treatment or when your dose is increased. Usually, the side effects will slowly go away as your body gets used to the Donep 5 Tablet. If they are severe or will not go away, you should contact your doctor.

Before using Donep 5 Tablet, you should tell your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma. It may also affect, or be affected by, some other drugs you are using so let your doctor know what these are to be safe. During pregnancy, this medicine should only be taken if it is advised.

Uses of Donep Tablet

Side effects of Donep Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Donep

Common cold
Urinary incontinence
Rash
Nausea
Diarrhea
Insomnia (difficulty in sleeping)
Weight loss
Accidental injury

How to use Donep Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Donep 5 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Donep Tablet works

Memory loss in Alzheimer’s disease occurs due to disturbances of signal transmission in the brain. Donep 5 Tablet is a cholinesterase inhibitor. It works by increasing the levels of a chemical messenger (acetylcholine) involved in transmmission of nerve signals. This improves memory and thinking.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Donep 5 Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Donep 5 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Donep 5 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Donep 5 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

SAFE IF PRESCRIBED

Donep 5 Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Donep 5 Tablet may not be needed in these patients. Please consult your doctor.

Liver

CAUTION

Donep 5 Tablet should be used with caution in patients with liver disease. Dose adjustment of Donep 5 Tablet may be needed. Please consult your doctor.

What if you forget to take Donep Tablet?

If you miss a dose of Donep 5 Tablet, skip it and continue with your normal schedule. Do not double the dose.\n

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Donep 5 Tablet

₹10.6/Tablet

Aricep 5 Tablet

Eisai Pharmaceuticals India Pvt Ltd

₹10/tablet

6% cheaper

Alzil 5 Tablet

Intas Pharmaceuticals Ltd

₹13.4/tablet

26% costlier

Donecept 5 Tablet

Cipla Ltd

₹12.8/tablet

21% costlier

Lapezil 5 Tablet

La Renon Healthcare Pvt Ltd

₹12.9/tablet

22% costlier

Dope 5mg Tablet

D D Pharmaceuticals

₹13.5/tablet

27% costlier

View all substitutes

Quick tips

You have been prescribed Donep 5 Tablet to slow down the progression of Alzheimer's disease.
It does not cure Alzheimer's disease but may help improve brain function and ability to do daily activities.
Take it with or without food, preferably at night before going to bed.
It may cause diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated while taking Donep 5 Tablet.
Monitor your body weight regularly as both Donep 5 Tablet and Alzheimer's disease can cause weight loss.
Do not drive or do anything that requires mental focus until you know how Donep 5 Tablet affects you.
Be cautious while taking this medicine if you suffer from peptic ulcer as it may cause vomiting, stomach bleeding, stomach pain, or discomfort.
Inform your doctor if you develop muscle tremors, especially if you have Parkinson’s disease.
Inform your doctor if you experience seizures or convulsions while taking this medicine.
You have been prescribed Donep 5 Tablet to slow down the progression of Alzheimer's disease.
It does not cure Alzheimer's disease but may help improve brain function and ability to do daily activities.
Take it with or without food, preferably at night before going to bed.
It may cause diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated while taking Donep 5 Tablet.
Monitor your body weight regularly as both Donep 5 Tablet and Alzheimer's disease can cause weight loss.
Do not drive or do anything that requires mental focus until you know how Donep 5 Tablet affects you.
Be cautious while taking this medicine if you suffer from peptic ulcer as it may cause vomiting, stomach bleeding, stomach pain, or discomfort.
Inform your doctor if you develop muscle tremors, especially if you have Parkinson’s disease.
Inform your doctor if you experience seizures or convulsions while taking this medicine.

Fact Box

Chemical Class

Carbamate Derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Cholinesterase Inhibitors

Interaction with drugs

Taking Donep with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Atropine (Injection Route) Moderate

If used together, Donepezil may interrupt with the efficacy of Atropine. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the obs... More

Bethanechol (Oral Route) Moderate

Bethanechol may increase the effect of Donepezil. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Ramelteon (Oral Route) Moderate

Donepezil may raise blood levels of Ramelteon. Watch out for symptoms such as drowsiness, impaired movement, tiredness, nausea, palpitations, or numbness, and consult your doctor ... More

Amitriptyline (Oral Route) Moderate

If used together, If used together, Amitriptyline may interrupt the efficacy of Donepezil. If concurrent use is essential, please consult your doctor. They may monitor your treatm... More

Carbachol (Injection Route) Moderate

Carbachol may increase the effect of Donepezil. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

View all drug interactions

Patient concerns

My father is suffering from alzheimer disease. Which medicine should I give or which doctor to approach? Neurologist or Pyschiatrist.

Dr. Vikas Sharma

Neurology

Neurologist Donep 5 mg daily

The patient has cerebral atrophy and hypertension. He is taking phenitoy,phenobarbitone,AHT and statin with aspirins. He had a brain stroke and fits 4 times. He remains confused. Also has imbalance. Advice him the best possible treatment. Thanks. Please advise the best possible treatment.Thanks.

Dr. Vikas Sharma

Neurology

start tab donep 5 mg daily; pls show to neurologist

User feedback

Patients taking Donep 5 Tablet

Twice A Day

50%

Once A Day

50%

What are you using Donep Tablet for?

Others

50%

Dementia in P*

50%

*Dementia in Parkinson's disease

How much was the improvement?

Poor

56%

Average

44%

What were the side-effects while using Donep 5 Tablet?

Fatigue

33%

Nausea

33%

Loss of appet*

33%

*Loss of appetite

FAQs

Why is Donep 5 Tablet taken at night?

Donep 5 Tablet is recommended to be taken before going to bed to reduce gastrointestinal side effects or nausea, which is commonly seen in some patients in the first few weeks of treatment.

Do the gastrointestinal side effects due to Donep 5 Tablet persist for a long time?

Gastrointestinal side effects may appear during the first few weeks of treatment with Donep 5 Tablet. This can be minimized by taking Donep 5 Tablet at bedtime and with food. Generally, these side effects are mild and disappear within a few weeks with continued treatment.

How long does it take for Donep 5 Tablet to start working?

Within the first month of treatment with Donep 5 Tablet, you may experience improvement in thinking and remembering (cognitive effect). However, it may take about 12 weeks to see the full benefits.

When should Donep 5 Tablet be stopped?

Do not stop Donep 5 Tablet without consulting your doctor. This medicine only helps to control your condition but does not cure it. Therefore, it may take several weeks to show benefits, so do not be discouraged if you do not see an improvement straight away. But, in case your condition starts worsening and you feel that it is no longer helping you, then you should consult a doctor before stopping it.

For how long does Donep 5 Tablet stay in your system?

Donep 5 Tablet gets removed from the body very slowly. It takes about two weeks or more for Donep 5 Tablet to be completely removed from the system.

Does Donep 5 Tablet cause depression?

No, Donep 5 Tablet does not cause depression. If you are experiencing symptoms, then it could be due to existing Alzheimer’s disease.

What if I take more than the prescribed dose of Donep 5 Tablet?

Taking more than the recommended dose of Donep 5 Tablet may cause vomiting, increased sweating or saliva production, slow heartbeat, dizziness, difficulty in breathing, seizures or fits, weakness, low blood pressure, convulsions, and inability to control your bowel motions or passing of urine (incontinence). You should seek immediate help from a doctor or emergency service of a nearby hospital.

I have been taking indomethacin for arthritis. Can I take Donep 5 Tablet?

Donep 5 Tablet does not interfere with the working of indomethacin, but indomethacin individually increases the risk of stomach bleeding when taken for a long time. Therefore, if you experience any symptoms of stomach bleeding, consult your doctor immediately.

Does Donep 5 Tablet cause hallucinations?

Hallucinations are a common side effect of Donep 5 Tablet, though not everyone is affected. Other common psychiatric side effects include agitation, aggressive behavior, nightmares, and abnormal dreams.

Who should not take Donep 5 Tablet?

Donep 5 Tablet should not be taken by patients who have hypersensitivity to Donep 5 Tablet hydrochloride, piperidine derivatives, or to any active ingredients used in the medicine. Also, it should not be used during pregnancy unless clearly necessary.

Can it cause insomnia?

Yes, insomnia (sleeplessness) is a common side effect of Donep 5 Tablet. Dizziness and fainting can also be seen as common side effects. Though these side effects are common, they do not occur in everyone.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Stahl SM, editor. Donepezil. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 199-202.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 426-27.
Donepezil hydrochloride. Woodcliff Lake, New Jersey: Eisai Inc.; 1996 [revised Feb. 2012]. [Accessed 25 Jan. 2019] (online) Available from:
Donepezil. Hatfield, Hertfordshire: Eisai Ltd.; 1997 [revised 11 May 2018]. [Accessed 25 Jan. 2019] (online) Available from:
Donepezil hydrochloride. South Ruislip, UK: Aurobindo Pharma - Milpharm Ltd.; 2013 [revised 23 Nov. 2017] [Accessed 19 Jun. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
Donepezil hydrochloride [Prescribing Information]. Mahabubnagar, Telangana: Hetero Labs Limited; 2023. [Accessed 20 June 2023]. (online) Available from:
Donepezil Hydrochloride [Summary of Product Characteristics]. Dublin, Ireland: Pfizer Healthcare Ireland; 2023. [Accessed 20 June 2023]. (online) Available from:

Marketer details

Name: Alkem Laboratories Ltd

Address: Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.

Country of origin: India

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