Dolo 650 Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 01 Apr 2026 | 05:21 PM (IST)

Product Summary :

Dolo 650 Tablet is an analgesic (pain-reliever) and antipyretic (fever-reducer) medicine that contains paracetamol. It is used to relieve fever and mild-to-moderate pain such as headache, muscle ache, body ache, and toothache. It works by blocking chemical messengers in the brain that cause pain and fever. When used as directed, it usually takes effect within 30–60 minutes. Dolo 650 Tablet is generally considered safe, but exceeding the recommended dose can lead to liver damage and other side effects.

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General Information

Storage

Store below 25°C

The content is shown in English

Product introduction

Dolo 650 Tablet helps relieve pain and fever by blocking the release of certain chemical messengers that trigger these symptoms. It is used to treat headaches, migraines, toothaches, period pains, arthritis, and muscle aches, and to reduce fever associated with infections such as the common cold and flu.

Dolo 650 Tablet has been one of the most widely prescribed paracetamol-based medications during the COVID-19 pandemic. It should be taken regularly as per the doctor’s advice. Take it with food to avoid an upset stomach. It may be taken alone or in combination with other medications. However, no more than four doses of Dolo 650 Tablet can be taken in 24 hours with a gap of at least 4 hours between two doses. Please do not take it for longer than recommended.

Generally, Dolo 650 Tablet is well tolerated, and side effects are rare. However, it may temporarily cause stomach pain, nausea, and vomiting in some people. Consult the doctor if any of these side effects persist or become bothersome.

Though Dolo 650 Tablet is essentially safe, it may not suit everyone. Before taking this medicine, let the doctor know if you have any liver or kidney problems, are allergic to it, or are taking other medications as this might affect the dose or suitability of the medicine. In general, take the lowest dose that works for the shortest possible time. It is also the first choice of painkillers during pregnancy or breastfeeding.

Uses of Dolo 650 Tablet

Pain relief : Dolo 650 Tablet helps relieve pain in conditions such as headaches, body aches, muscle aches, toothaches, menstrual cramps, and minor injuries.
Treatment of Fever : Dolo 650 Tablet helps relieve fever in conditions such as flu, viral infections, post-vaccination reactions, and other illnesses associated with fever.

Benefits of Dolo 650 Tablet

Pain relief
Dolo 650 Tablet works by blocking pain signals in the brain, helping reduce the sensation of pain. This leads to relief from discomfort and improves daily functioning, making the patients feel more comfortable and active.

Treatment of Fever
Dolo 650 Tablet helps reduce fever by lowering the body’s temperature through its action on the brain. This helps lower high temperatures and relieves associated symptoms such as chills and body aches. Managing fever can prevent dehydration and excessive discomfort. As a result, patients may feel better and recover more comfortably.

Side effects of Dolo 650 Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Dolo 650 Tablet

Nausea
Vomiting
Constipation
Itching
Headache
Insomnia (difficulty in sleeping)

How to use Dolo 650 Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dolo 650 Tablet should be taken with or after food.

How Dolo 650 Tablet works

Dolo 650 Tablet is an analgesic (pain reliever) and anti-pyretic (fever reducer). It works by blocking the release of certain chemical messengers that cause pain and fever.

Dosage

The dose of Dolo 650 Tablet depends on your age, body weight, the condition being treated, and your overall health. In adults, the usual dose is 500–1000 mg every 4–6 hours. In children, the dose is typically 10–15 mg/kg per dose, administered every 4–6 hours as needed for pain or fever. However, your doctor will decide the right dose and duration of treatment for you.

Do not take more than the prescribed dose, as taking too much may seriously harm your liver. Use Dolo 650 Tablet only for the recommended duration. If your symptoms do not improve or get worse, consult your doctor.

Missed Dose

If you miss a dose of Dolo 650 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Overdose

Overdose may cause serious harm, particularly to the liver. Symptoms may include nausea or vomiting, loss of appetite, abdominal discomfort, general malaise, or sweating. In case of suspected overdose, discontinue the medicine immediately and contact your doctor.

All substitutes for Dolo 650 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Leemol 650mg Tablet

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₹1.49/tablet

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Parafast 650mg Tablet

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₹1.52/tablet

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P 650 Tablet

by Apex Laboratories Pvt Ltd

₹1.93/tablet

1% cheaper

Pacimol 650 Tablet

by Ipca Laboratories Ltd

₹1.83/tablet

6% cheaper

Dolopar 650 Tablet

by Micro Labs Ltd

₹1.9/tablet

2% cheaper

Quick tips

Dolo 650 Tablet can be taken with or without food, but taking it with food or milk may help reduce stomach discomfort.
Avoid taking more than the recommended dose, as excessive use can increase the risk of liver damage.
Check the labels of other “cold and flu” medicines, as many may also contain paracetamol. Taking them together can lead to an overdose.
Avoid alcohol while taking Dolo 650 Tablet, as it may increase the risk of liver damage.
Inform your doctor if you have liver or kidney disease, as dose adjustment or monitoring may be required, especially with long-term use.
Seek medical advice if you notice symptoms such as dark urine, yellowing of the skin or eyes, or unusual tiredness. These may indicate liver problems.
Consult your doctor if the fever or pain lasts for more than a few days.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Dolo 650 Tablet.

Pregnancy

SAFE IF PRESCRIBED

Dolo 650 Tablet is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.

Breast feeding

SAFE IF PRESCRIBED

Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.

Driving

SAFE

Dolo 650 Tablet does not usually affect your ability to drive.

Kidney

CAUTION

Dolo 650 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
However, Dolo 650 Tablet contains paracetamol which is considered the safest painkiller for kidney disease patients.

Liver

UNSAFE

Dolo 650 Tablet is unsafe to use in patients with liver disease and should be avoided.
However, the use of Dolo 650 Tablet is not recommended in patients with severe liver disease and active liver disease.

Interaction with drugs

Taking Dolo with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Bemiparin (Injection Route)

If concurrent use is essential, watch out for symptoms such as fatigue, nausea, loss of appetite, dark urine or jaundice and consult your doctor if you experience them. They may adjust the doses as per the observations.

Moderate

Certoparin (Injection Route)

Moderate

Cholestyramine (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Paracetamol may increase the effect of Cholestyramine.

Moderate

Dalteparin (Injection Route)

Moderate

Enoxaparin (Injection Route)

Frequently asked questions

What if I vomit after taking Dolo 650 Tablet?

If you vomit shortly after taking Dolo 650 Tablet, the amount of medicine absorbed into your body will depend on how quickly you vomited after taking it. If you vomit within 15 to 30 minutes of taking the dose, the dose may be repeated.

What is Dolo 650 Tablet, and what is it used for?

Dolo 650 Tablet is a widely used pain reliever and fever reducer. It works by blocking certain chemical signals in the brain that cause pain and raise body temperature. It is used for fever and mild to moderate pain such as headaches, toothaches, muscle aches, and body pain.

How long will it take Dolo 650 Tablet to reduce my fever, and when will I start feeling better?

Dolo 650 Tablet generally begins to reduce fever and relieve pain within 30 to 60 minutes of an oral dose. The effect usually peaks at 1 to 2 hours and typically lasts 4 to 6 hours, after which another dose may be taken if needed.

Can I take Dolo 650 Tablet and ibuprofen together?

Yes, in most adults, paracetamol and ibuprofen can be taken together safely. They belong to different classes of medicines and work in different ways, so combining them does not increase the risk of side effects. However, people with stomach ulcers or inflammatory bowel disease, kidney problems, or pregnant women should consult their doctor before taking them together.

Is Dolo 650 Tablet safe for children, and can it be given to kids under 12?

Yes, Dolo 650 Tablet is widely considered safe for children, including infants. Do not give adult-strength tablets to young children. Always consult a doctor before giving it to your child.

How much Dolo 650 Tablet can I take in a day, and how long should I wait between doses?

For most adults, do not exceed 4 g (4000 mg) in 24 hours. The medicine's effect typically lasts up to 4 to 6 hours, after which another dose may be taken if needed. Paracetamol may be present in many other medicines for cold, flu, and pain relief. Taking Dolo 650 Tablet with them may increase the total dose in your body, increasing the risk of liver damage.

What happens if I take Dolo 650 Tablet even if I do not have a fever?

If taken at the recommended dose without fever, Dolo 650 Tablet will simply relieve pain without causing any abnormal drop in body temperature. If you regularly take it for ongoing pain without a clear reason, or if your symptoms persist or worsen, consult your doctor for proper assessment.

Can I take Dolo 650 Tablet if I have a known liver condition?

The liver primarily processes (metabolizes) paracetamol, and taking too much can cause serious liver damage. If you have a known liver condition, discuss your situation with your doctor, as you may require dose adjustment and monitoring.

What should I do if I accidentally take a double dose of Dolo 650 Tablet?

Taking one extra dose of paracetamol is usually not harmful for a healthy adult. It is slightly above the usual single dose but well below dangerous levels. In such a case, skip the next dose for 8–10 hours. Avoid alcohol, and do not take any other medicines containing paracetamol. Stay hydrated and eat light. However, if you have liver disease, drink alcohol regularly, take repeated high doses, or notice symptoms such as vomiting, abdominal pain (right side), yellowing of skin/eyes, unusual fatigue, or dark urine, consult your doctor.

Can I take Dolo 650 Tablet along with my daily blood pressure medication?

Always inform your doctor that you are on blood pressure medication before regularly using any painkiller, including paracetamol. In general, paracetamol is considered one of the safer pain-relief options for people taking blood pressure (antihypertensive) medication, particularly when compared to other anti-inflammatory medicines.

Fact Box of Dolo 650 Tablet

Chemical Class

1- hydroxy- 2- unsubstituted benzenoids

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

Analgesic & Antipyretic-PCM

Related lab tests

Complete Blood Count

References

Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 635-36.
Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 982-84.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 8-12.
Paracetamol. County Tipperary, Ireland: Pinewood Healthcare; 2015. [Accessed 17 Jun. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 02 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:

User feedback

Patients taking Dolo 650 Tablet

Thrice A Day

70%

Once A Day

20%

Twice A Day

10%

What are you using Dolo Tablet for?

Fever

57%

Pain relief

22%

Headache

10%

Others

Pain during menstruation

How much was the improvement?

Average

41%

Excellent

37%

Poor

22%

What were the side-effects while using Dolo 650 Tablet?

No Side Effect

89%

Liver damage

Allergic reaction

How do you take Dolo Tablet?

With food

82%

With or without food

13%

Empty stomach

Please rate Dolo 650 Tablet on price

Not Expensive

35%

Average

33%

Expensive

31%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Manufacturer details

Name: A)MICRO LABS LIMITED
Address: A)Mamring, Namthang Road, South Sikkim-737 132

Marketer details

Name: Micro Labs Ltd
Address: 27, RACE COURSE ROAD, BANGALORE-560 001, INDIA

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Dolo 650 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Dolo 650 Tablet

Product Summary :

Save more with additional offers

Save more with additional offers

General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Dolo 650 Tablet

Benefits of Dolo 650 Tablet

Side effects of Dolo 650 Tablet

How to use Dolo 650 Tablet

How Dolo 650 Tablet works

Dosage

Missed Dose

Overdose

All substitutes for Dolo 650 Tablet

Leemol 650mg Tablet

Parafast 650mg Tablet

P 650 Tablet

Pacimol 650 Tablet

Dolopar 650 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Bemiparin (Injection Route)

Certoparin (Injection Route)

Cholestyramine (Oral Route)

Dalteparin (Injection Route)

Enoxaparin (Injection Route)

Frequently asked questions

What if I vomit after taking Dolo 650 Tablet?

What is Dolo 650 Tablet, and what is it used for?

How long will it take Dolo 650 Tablet to reduce my fever, and when will I start feeling better?

Can I take Dolo 650 Tablet and ibuprofen together?

Is Dolo 650 Tablet safe for children, and can it be given to kids under 12?

How much Dolo 650 Tablet can I take in a day, and how long should I wait between doses?

What happens if I take Dolo 650 Tablet even if I do not have a fever?

Can I take Dolo 650 Tablet if I have a known liver condition?

What should I do if I accidentally take a double dose of Dolo 650 Tablet?

Can I take Dolo 650 Tablet along with my daily blood pressure medication?

Fact Box of Dolo 650 Tablet

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

References

User feedback

Patients taking Dolo 650 Tablet

What are you using Dolo Tablet for?

How much was the improvement?

What were the side-effects while using Dolo 650 Tablet?

How do you take Dolo Tablet?

Please rate Dolo 650 Tablet on price

Want to know more

Have issue with the content

Disclaimer

Manufacturer details

Marketer details

Vendor Details

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