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Divigel 0.1% Gel

Prescription Required
SALT COMPOSITION

Overview

Introduction

Divigel 0.1% Gel is a female sex hormone (estrogen). This is a hormone replacement therapy (HRT) that is used to treat symptoms associated with menopause (hot flushes, vaginal dryness and itching),estrogen deficiency (hypoestrogenism), and thinning of bones (osteoporosis).

Divigel 0.1% Gel should be used as per the provided instructions by the doctor. Even if your symptoms improve, you should continue the treatment as it has been prescribed. The course of the treatment must be completed for better efficacy.

The most common side effects that you may experience are headaches, breast pain, abdominal cramps, bloating, nausea and vomiting, hair loss, fluid retention, and vaginal yeast infection. Tell your doctor if you notice bleeding from your vagina or develop breast lumps.

Before using this medicine you should tell your doctor if you have unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. Once you have started using this medicine you should have regular check-ups to discuss the benefits of your treatment. It should not interact with any other medicines but it is not usually recommended during pregnancy or breastfeeding.

Uses of Divigel Transdermal Patch

Side effects of Divigel Transdermal Patch

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Divigel

  • Headache
  • Bloating
  • Breast pain
  • Nausea
  • Back pain
  • Common cold

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Headache
    Make sure you rest and drink plenty of fluids. Rest in a quiet, dimly lit room. Do not sleep more than you normally would. Do not strain your eyes (for example by looking at a screen). Do not drink alcohol. Headaches are usually temporary and usually go away with time. But, if they last longer or get worse, ask your doctor to recommend a painkiller.
  • Coping with Bloating
    Try eating small and frequent meals. Drink and chew your food slowly. Exercise regularly to improve how your body digests food. Try not to swallow too much air. This can happen when you talk and eat at the same time. Avoid drinking with a straw, chewing gum and smoking as these can also make you swallow air. Try to limit foods that are hard to digest or produce gas (such as fried and fatty foods, cheese, beans, cabbage, onion, whole grains and many others). Avoid drinking alcohol, carbonated soft drinks and fruit juices. If you wear dentures, make sure they fit properly. Some over-the-counter medicines can help. Talk to your doctor about possible medication if your condition does not improve.
  • Coping with Breast pain
    Use hot or cold compresses on your breasts. You could try some pain-relieving creams or gels. Wear bras which fit well. Wear a soft support bra when you sleep and a good sports bra when you are exercising. Avoid consuming caffeinated drinks as it can increase the discomfort. Limit your salt intake as it contributes to water retention which causes pain and swelling. Talk to your doctor because in many cases, it is possible to treat breast pain with over-the-counter medicines.
  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Back pain
    Stay as active as possible and try to continue your daily activities. Do not rest for long periods. Try exercises and stretches specifically designed for back pain. Walking, swimming, yoga and pilates may also be helpful. Taking baths with salt water after exercise may also reduce the pain. Hot or cold compression packs and gentle back massage can give short-term relief. Take anti-inflammatory painkillers if you need to. Back pain normally gets better on its own but if it is severe or lasts more than a couple of weeks, you should see a doctor.
  • Coping with Common cold
    Get plenty of rest as exhausting or stressing out yourself could aggravate your condition. You should drink plenty of fluids as it will keep your throat moist and comfortable. Try taking steam inhalation. The moisture can ease your breathing and loosen mucus. You can consider sipping warm water or tea with honey and lemon. This will keep your nose and throat from being too dry. Using an air humidifier may also help. You can also gargle with salt water several times a day. See your doctor if your symptoms last longer than 3 weeks or get worse quickly. Avoid alcohol and do not smoke as they can aggravate your conditions.

How to use Divigel Transdermal Patch

Use this medicine in dose and duration as advised by your doctor. Check the label before use. Make sure the skin is clean and dry. Remove the protective liner of the patch. Do not touch the sticky side. With sticky side down, place the patch evenly onto the skin.

How Divigel Transdermal Patch works

Divigel 0.1% Gel is an estrogen (female sex hormone). In women who are undergoing or have attained menopause, it prevents symptoms such as hot flushes, night sweats and mood swings. It also prevents the bones from becoming porous and fragile (osteoporosis).

Safety Advice

Alcohol
No interaction found/established
Pregnancy
UNSAFE
Divigel 0.1% Gel is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breastfeeding
UNSAFE
Divigel 0.1% Gel is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
No interaction found/established
Kidney
CAUTION
Divigel 0.1% Gel should be used with caution in patients with kidney disease. Dose adjustment of Divigel 0.1% Gel may be needed. Please consult your doctor.
Liver
CAUTION
Divigel 0.1% Gel should be used with caution in patients with liver disease. Dose adjustment of Divigel 0.1% Gel may be needed. Please consult your doctor.
Use of Divigel 0.1% Gel is not recommended in patients who previously had liver disease and the liver function tests are still not normal.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
No alternate brands found for this medicine

Quick Tips

  • You have been prescribed Divigel 0.1% Gel as a part of hormone replacement therapy to relieve symptoms of menopause.
  • It may also be used for preventing osteoporosis in postmenopausal women who are at high risk of fractures.
  • It has a lower risk of side effects since lower amount of estrogen is used in patches.
  • Apply it once a week, to a clean, dry, unbroken, non-irritated area of skin below the waist, on the lower back or buttocks. Do not expose it to sunlight.
  • Replace it every 7 days, and apply on a different area of skin to prevent skin irritation.
  • Inform your doctor if you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort while taking Divigel 0.1% Gel.
  • Stop taking this medicine and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision. These could be symptoms of a blood clot in a vein.

Fact Box

Chemical Class
Estradiol Congeners
Habit Forming
No

Interaction with Drugs

Taking Divigel with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Altrom, Cenorol, Cgtrom
LIFE-THREATENING
Brand(s): Avizole, Worm Hunt, Womgo
LIFE-THREATENING
Brand(s): Fetrop, Fertitone, Pifert
LIFE-THREATENING
Brand(s): Donogen
LIFE-THREATENING

Patient Concerns

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I have been told by doctors I have cystitis also simple cyst in right ovary . What should I be doing its been two years I have this issue
Dr. Megha Tuli
Obstetrics and Gynaecology
Hi PATIENT hormone therapy helps with cysts. Ask your doctor for a hormone replacement.
I am a male to female transsexual and I need Bilateral Orchiectomy at a fair cost I am already on hormone replacement therapy for 2 years anti androgen/spirnolactone (Aldactone) and estrodiol valerate progynova, I need to have bilateral orchiectomy at the cheapest option
Dr. Deepak Kumar Soni
Ayurveda
Hi Kindly consult to your nearest doctor
arrow
Do you have any questions related to Divigel 0.1% Gel ?

FAQs

Q. What is Divigel and what is it used for?

Divigel is a transdermal patch, which contains a medicine called Estradiol (a female sex hormone). It helps in treating estrogen deficiency symptoms like hot flushes (red and warm face), vaginal dryness in women.  It is also used to prevent osteoporosis (thinning and weakening of bone) in postmenopausal women, who are at high risk of fractures and can not take other preventive medicines for osteoporosis.

Q. When and how to take Divigel?

Take Divigel as per the advice by your doctor. It is a patch that is applied to the skin. The medicine is released from the patch and absorbed through the skin into your bloodstream.

Q. Where to apply Divigel?

It is applied to the skin. You can stick the patch on to a hairless area of skin below the waist. You can also use it in the places like buttock, lower back, hip or abdomen. Make sure that the applied site is dry and clean.

Q. What are the most common side effects of using Divigel?

The common side effects associated with Divigel are application site reaction (redness, pain or itching), breast pain or tenderness, breakthrough vaginal bleeding, headache, nausea and stomach pain. If any of these side effects bother you, please consult with your doctor.

Q. What are Divigel used for?

Divigel is used to treat dryness, itching, and burning in and around the vagina. It reduces the chances of moderate or severe hot flashes in menopausal women and also reduces the risk of osteoporosis. It also treats certain conditions in which a young woman’s ovaries do not produce enough estrogen naturally.

Q. How should Divigel be used?

Apply it exactly as advised by your doctor. It should be applied below the panty line and not on breasts or any other area of the body. You can also use it on your buttocks. Wash and dry the area before using. The area should be free of any cuts, bruises, lotions, or creams. When you change your patch, do not put the new one in the same place. To help reduce the chance of skin redness or irritation, wait at least 1 week before you reuse a spot.

Related Products

Disclaimer:

1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Levin ER, Hammes SR. Estrogens and Progestins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1173-75.
  2. Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 701-702.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 500-501.
  4. Estradiol. Luxembou: Merus Labs Luxco II S.à R.L; 2009 [revised 25 Apr. 2016]. [Accessed 03 Apr. 2019] (online) Available from:External Link
  5. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 03 Apr. 2019] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 04 Apr. 2019] (online) Available from:External Link

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