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Divigel 0.1% Gel

Prescription Required
Store below 30°C

Product introduction

Divigel 0.1% Gel is a female sex hormone (estrogen). This is a hormone replacement therapy (HRT) that is used to treat symptoms associated with menopause (hot flushes, vaginal dryness and itching), estrogen deficiency (hypoestrogenism), and thinning of bones (osteoporosis).

Divigel 0.1% Gel should be used as per the provided instructions by the doctor. Even if your symptoms improve, you should continue the treatment as it has been prescribed. The course of the treatment must be completed for better efficacy.

The most common side effects of this medicine include breast discomfort, abnormal menstrual bleeding, application site reactions, headache, nausea, abdominal pain, and abdominal distension. If any of these side effects bother you, consult your doctor. Also, tell your doctor if you notice bleeding from your vagina or develop breast lumps.

Before using this medicine you should tell your doctor if you have unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. Once you have started using this medicine you should have regular check-ups to discuss the benefits of your treatment. It should not interact with any other medicines but it is not usually recommended during pregnancy or breastfeeding.

Uses of Divigel Transdermal Patch

Benefits of Divigel Transdermal Patch

In Hormone replacement therapy

Hormone placement therapy (HRT) is a treatment to relieve symptoms of menopause such as hot flushes, night sweats, mood swings, vaginal dryness, and reduced sex drive. Since menopause can last for several years, this treatment can make a big improvement to your daily life and mood. Estrogen is one of two important hormones (the other is progesterone) used in this treatment. You should use this medicine as it is prescribed, and for as long as it is prescribed by your doctor.

Side effects of Divigel Transdermal Patch

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Divigel

  • Application site reactions (burning, irritation, itching and redness)
  • Breast discomfort
  • Abnormal menstrual bleeding
  • Headache
  • Nausea
  • Abdominal pain
  • Abdominal distension

How to use Divigel Transdermal Patch

Use this medicine in dose and duration as advised by your doctor. Check the label before use. Make sure the skin is clean and dry. Remove the protective liner of the patch. Do not touch the sticky side. With sticky side down, place the patch evenly onto the skin.

How Divigel Transdermal Patch works

Divigel 0.1% Gel contains a medication called estrogen (female sex hormone). It works by replacing estrogen that is normally produced by the body.

Safety advice

No interaction found/established
Divigel 0.1% Gel is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
Divigel 0.1% Gel is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
No interaction found/established
Divigel 0.1% Gel should be used with caution in patients with kidney disease. Dose adjustment of Divigel 0.1% Gel may be needed. Please consult your doctor.
Divigel 0.1% Gel should be used with caution in patients with liver disease. Dose adjustment of Divigel 0.1% Gel may be needed. Please consult your doctor.
Use of Divigel 0.1% Gel is not recommended in patients who previously had liver disease and the liver function tests are still not normal.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine

Quick tips

  • You have been prescribed Divigel 0.1% Gel as a part of hormone replacement therapy to relieve symptoms of menopause.
  • It may also be used for preventing osteoporosis in postmenopausal women who are at high risk of fractures.
  • It has a lower risk of side effects since lower amount of estrogen is used in patches.
  • Apply it once a week, to a clean, dry, unbroken, non-irritated area of skin below the waist, on the lower back or buttocks. Do not expose it to sunlight.
  • Replace it every 7 days, and apply on a different area of skin to prevent skin irritation.
  • Inform your doctor if you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort while taking Divigel 0.1% Gel.
  • Stop using this medicine and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision. These could be symptoms of a blood clot in a vein.

Fact Box

Chemical Class
Estradiol Congeners
Habit Forming
Therapeutic Class
Action Class

Interaction with drugs

Taking Divigel with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Altrom, Cenorol, Cgtrom
Brand(s): Avizole, Albendex, Wormkut
Brand(s): Fetrop, Fertitone, Pifert
Brand(s): Donogen

Patient concerns

I have been told by doctors I have cystitis also simple cyst in right ovary . What should I be doing its been two years I have this issue
Dr. Megha Tuli
Obstetrics and Gynaecology
Hi PATIENT hormone therapy helps with cysts. Ask your doctor for a hormone replacement.
I am a male to female transsexual and I need Bilateral Orchiectomy at a fair cost I am already on hormone replacement therapy for 2 years anti androgen/spirnolactone (Aldactone) and estrodiol valerate progynova, I need to have bilateral orchiectomy at the cheapest option
Dr. Deepak Kumar Soni
Hi Kindly consult to your nearest doctor

User feedback


Q. Where to apply Divigel 0.1% Gel?

It is applied to the skin. You can stick the patch on to a hairless area of skin below the waist. You can also use it in places like buttock, lower back, hip or abdomen. Make sure that the applied site is dry and clean.

Q. What are the most common side effects of using Divigel 0.1% Gel?

The common side effects associated with Divigel 0.1% Gel are application site reaction (redness, pain or itching), breast pain or tenderness, breakthrough vaginal bleeding, headache, nausea and stomach pain. If any of these side effects bother you, please consult with your doctor.

Q. How should Divigel 0.1% Gel be used?

Apply it exactly as advised by your doctor. It should be applied below the panty line and not on breasts or any other area of the body. You can also use it on your buttocks. Wash and dry the area before using. The area should be free of any cuts, bruises, lotions, or creams. When you change your patch, do not put the new one in the same place. To help reduce the chance of skin redness or irritation, wait at least 1 week before you reuse a spot.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Levin ER, Hammes SR. Estrogens and Progestins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1173-75.
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  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 500-501.
  4. Estradiol. Luxembou: Merus Labs Luxco II S.à R.L; 2009 [revised 25 Apr. 2016]. [Accessed 03 Apr. 2019] (online) Available from:External Link
  5. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 03 Apr. 2019] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 04 Apr. 2019] (online) Available from:External Link
  7. Oestradiol [Package Leaflet]. Uxbridge, UK: Norgine Pharmaceuticals Limited. [Accessed 24 June 2023]. (online) Available from:External Link

Marketer details

Name: Win-Medicare Pvt Ltd
Address: 1309, 14th Floor, Madi Tower, 98, Nehru Place, New Delhi, Delhi 110019
Country of origin: India

Inclusive of all taxes
MRP615  8% OFF
1.0 gm in 1 tube
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