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Distinon Tablet

Pyridostigmine (60mg)

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Distinon Tablet is used in the treatment of myasthenia gravis (a disease-causing muscle weakness and tiredness). It helps strengthen the muscles, promotes bowel function, and stimulates the bladder muscles.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 05 Jan 2026 | 05:03 PM (IST)

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10 tablets

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Gurgaon

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General Information

Contains

Pyridostigmine (60mg)

Marketer

Samarth Life Sciences Pvt Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Distinon Tablet should be taken on an empty stomach, preferably at the same time each day. Take this medicine in the dose and duration as advised by your doctor. If you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment. You should never stop this medicine suddenly without talking to your doctor.

Some common side effects of using this medication are nausea, excessive salivation, diarrhea, blurred vision, shortness of breath, watery eyes, abdominal pain, and altered frequency of urination. Some other side effects that may be seen with it include sweating, headache, runny nose, and heartburn. It may also cause dizziness and sleepiness. So, avoid doing any such work that requires focus and attention, such as driving or operating any machinery.

Before taking Distinon Tablet, it is better to inform your doctor if you are suffering from any kidney problems, Parkinson's disease, asthma, or stomach disorders. Your blood pressure may decrease after taking this medicine, so it is better to monitor it and consult your doctor if it bothers you. This medicine may cause diarrhea, so drink plenty of fluids to keep yourself hydrated while taking this medicine. Inform your doctor if you are pregnant, planning to conceive or breastfeeding, before taking this medicine.

Uses of Distinon Tablet

Treatment of Myasthenia gravis

Benefits of Distinon Tablet

Treatment of Myasthenia gravis
Myasthenia gravis is a neuromuscular disorder that leads to weakness of muscles that are under our control, such as those of the eyes, face, and swallowing. It can result in double vision, drooping eyelids, trouble talking, and trouble walking. It happens due to impaired coordination between muscles and nerves. Distinon Tablet makes this coordination between nerves and muscles better and relieves the symptoms. As a result, your muscle strength is improved and you are able to lead a better life.

Side effects of Distinon Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Distinon

Increased bronchial secretions
Nausea
Excessive salivation
Diarrhea
Blurred vision
Breathlessness
Watery eyes
Abdominal pain
Altered frequency of urination
Sweating
Headache
Dizziness
Runny nose
Heartburn
Gastro-esophageal reflux disease
Paresthesia (tingling or pricking sensation)
Muscle twitching
Weakness
Muscle cramp

How to use Distinon Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Distinon Tablet may be taken with or without food.

How Distinon Tablet works

Distinon Tablet increases the levels of acetylcholine (chemical messenger) which allows free transmission of signals across the nerves and muscles.

All substitutes for Distinon Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

You have been prescribed Distinon Tablet for treatment of myasthenia gravis.
It may also be used to treat inactivity of the muscle in the intestines (paralytic ileus) and difficulty in passing urine (urinary retention) after an operation.
Take it as per the dose and duration advised by your doctor. Overdosing can result in extreme muscle weakness.
It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
Do not drink alcohol while taking this medicine as it may worsen the side effects.
Inform your doctor if you have an existing kidney problem, parkinson's disease, asthma, or stomach disorders.
You have been prescribed Distinon Tablet for treatment of myasthenia gravis.
It may also be used to treat inactivity of the muscle in the intestines (paralytic ileus) and difficulty in passing urine (urinary retention) after an operation.
Take it with food to avoid an upset stomach.
Take it as per the dose and duration advised by your doctor. Overdosing can result in extreme muscle weakness.
It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
Do not drink alcohol while taking this medicine as it may worsen the side effects.
Inform your doctor if you have an existing kidney problem, parkinson's disease, asthma, or stomach disorders.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Distinon Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Distinon Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Distinon Tablet during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Distinon Tablet may cause side effects that could affect your ability to drive.

Kidney

CAUTION

Distinon Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Distinon Tablet in patients with liver disease.

Interaction with drugs

Taking Distinon with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Amikacin (Injection Route)

Your doctor may monitor the effects of Pyridostigmine along with your overall treatment and adjust the doses as per the observations. Amikacin may block the action of Pyridostigmine.

Moderate

Gentamicin (Injection Route)

Your doctor may monitor the effects of Pyridostigmine along with your overall treatment and adjust the doses as per the observations. Gentamicin may block the action of Pyridostigmine.

Moderate

Kanamycin (Injection Route)

Your doctor may monitor the effects of Pyridostigmine along with your overall treatment and adjust the doses as per the observations. Kanamycin may block the action of Pyridostigmine.

Moderate

Neomycin (Oral Route)

Your doctor may monitor the effects of Pyridostigmine along with your overall treatment and adjust the doses as per the observations. Neomycin may block the action of Pyridostigmine.

Moderate

Netilmicin (Injection Route)

Your doctor may monitor the effects of Pyridostigmine along with your overall treatment and adjust the doses as per the observations. Netilmicin may block the action of Pyridostigmine.

Frequently asked questions

Does Distinon Tablet cure myasthenia gravis? For how long do I need to take it?

Distinon Tablet helps reduce and improve muscle weakness and hence relieves the symptoms of myasthenia gravis but does not cure it. The length of time for which you have to take Distinon Tablet will depend on your needs. You should not stop taking Distinon Tablet until and unless advised by your doctor, even if you start feeling better.

Will Distinon Tablet have any effect on my baby if I am breastfeeding?

A very small quantity of Distinon Tablet passes into breast milk, which may or may not affect your baby. Ask your doctor if you can continue to breastfeed your baby.

Can I take Distinon Tablet for constipation?

No, Distinon Tablet should not be taken for any type of constipation. It is used only when constipation occurs due to paralysis of the intestine and strictly on prescription by the doctor.

Who should not take Distinon Tablet?

Distinon Tablet should not be taken by patients who are allergic to it. It should also be avoided by patients who are constipated or cannot urinate, unless the doctor has advised to use this medicine. This is because Distinon Tablet is only used to treat certain types of constipation and inability to pass urine.

What should I do if I have accidentally taken more than the required dose?

You should immediately seek help at a nearby hospital or contact your doctor urgently. An excess dose of Distinon Tablet may cause stomach pain, nausea, vomiting, diarrhea, excessive sweating, salivation, blurred vision, excessive weakness, difficulty in breathing, and even paralysis.

Is Distinon Tablet a steroid?

No, Distinon Tablet is not a steroid. It belongs to anticholinesterases group of medicines. Distinon Tablet works by preventing the breakdown of a chemical called acetylcholine.

Does Distinon Tablet have any abuse potential?

No, there is no evidence that Distinon Tablet has abuse potential.

Does it cause weight gain?

No, Distinon Tablet does not cause weight gain. If you experience weight gain, it may be due to inactivity related to muscle weakness in myasthenia gravis.

Is Distinon Tablet safe to use?

Yes, Distinon Tablet is safe if used according to the doctor’s advice. You should not exceed the dose as prescribed by the doctor.

Is it safe to drive if I have taken Distinon Tablet?

Distinon Tablet may cause blurred vision, and therefore you should limit driving until you know how it affects you.

Fact Box

Chemical Class

N- methylpyridinium compounds

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Carbamate-Based Cholinesterase Inhibitors

Related lab tests

Acetyl Choline Receptor Antibody

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1172-73.
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Pyridostigmine. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:
Pyridostigmine. Hertfordshire, UK: Mylan Products Limited; 1998 [revised 27 Feb. 2018]. [Accessed 22 Mar. 2019] (online) Available from:
Pyridostigmine Bromide [New Zealand Consumer Medicine Information]. Auckland, New Zealand: iNova Pharmaceuticals (NZ) Limited; 2022. [Accessed 05 Aug 2023] (online) Available from:
Taj Life Sciences. Pyridostigmine bromide [Product Information]. [Accessed 05 Aug 2023] (online) Available from:
Pyridostigmine bromide [Prescribing Information]. Bridgewater, NJ: Bausch Health US, LLC.; 2020. [Accessed 05 Aug. 2023] (online) Available from:
Amoxycillin and clavulanic acid. Sweden: Bluefish Pharmaceuticals AB; 2025. [Accesses 05 Jan. 2026] (online). Available from:

User feedback

Patients taking Distinon Tablet

Thrice A Day

83%

Once A Day

17%

What are you using Distinon Tablet for?

Myasthenia gravis

91%

Reversal of effect of skeletal muscle relaxant after surgery

Others

How much was the improvement?

Excellent

54%

Average

35%

Poor

11%

What were the side-effects while using Distinon Tablet?

No Side Effect

29%

Blurred vision

14%

Abdominal cramp

14%

Diarrhea

14%

Nausea

14%

How do you take Distinon Tablet?

Empty stomach

42%

With food

33%

With or without food

25%

Please rate Distinon Tablet on price

Expensive

58%

Average

36%

Not Expensive

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Samarth Life Sciences Pvt Ltd
Address: 136, New Ashirwad Ind. Est. No.5, Ram Mandir Road, Goregaon (W), Mumbai - 400 104, India || Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Distinon Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Distinon Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Distinon Tablet

Benefits of Distinon Tablet

Side effects of Distinon Tablet

How to use Distinon Tablet

How Distinon Tablet works

All substitutes for Distinon Tablet

Gravitor Tablet

Myestin 60mg Tablet

Myestine 60mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Amikacin (Injection Route)

Gentamicin (Injection Route)

Kanamycin (Injection Route)

Neomycin (Oral Route)

Netilmicin (Injection Route)

Frequently asked questions

Does Distinon Tablet cure myasthenia gravis? For how long do I need to take it?

Will Distinon Tablet have any effect on my baby if I am breastfeeding?

Can I take Distinon Tablet for constipation?

Who should not take Distinon Tablet?

What should I do if I have accidentally taken more than the required dose?

Is Distinon Tablet a steroid?

Does Distinon Tablet have any abuse potential?

Does it cause weight gain?

Is Distinon Tablet safe to use?

Is it safe to drive if I have taken Distinon Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Acetyl Choline Receptor Antibody

References

User feedback

Patients taking Distinon Tablet

What are you using Distinon Tablet for?

How much was the improvement?

What were the side-effects while using Distinon Tablet?

How do you take Distinon Tablet?

Please rate Distinon Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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