Distinon Tablet

Prescription Required
Store at room temperature (10-30°C)


Distinon Tablet is used in the treatment of myasthenia gravis (a disease-causing muscle weakness and tiredness), paralytic ileus (paralysis of intestinal muscles), postoperative urinary retention, and reversal of effect of skeletal muscle relaxants after surgery.

Distinon Tablet works by reducing and improving muscle weakness. It should be taken on an empty stomach, preferably at the same time each day. Take this medicine in the dose and duration as advised by your doctor. If you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment. You should never stop this medicine suddenly without talking to your doctor.

Some common side effects of using this medication are nausea, excessive salivation, diarrhea, blurred vision, shortness of breath, watery eyes, abdominal pain, and altered frequency of urination. Some other side effects that may be seen with it include sweating, headache, runny nose, and heartburn. It may also cause dizziness and sleepiness. So, avoid doing any such work that requires focus and attention, such as driving or operating any machinery.

Before taking Distinon Tablet, it is better to inform your doctor if you are suffering from any kidney problems, Parkinson's disease, asthma, or stomach disorders. Your blood pressure may decrease after taking this medicine, so it is better to monitor it and consult your doctor if it bothers you. This medicine may cause diarrhea, so drink plenty of fluids to keep yourself hydrated while taking this medicine. Inform your doctor if you are pregnant, planning to conceive or breastfeeding, before taking this medicine.

Uses of Distinon Tablet

Benefits of Distinon Tablet

In Myasthenia gravis

Myasthenia gravis is a neuromuscular disorder that leads to weakness of muscles that are under our control, such as those of the eyes, face, and swallowing. It can result in double vision, drooping eyelids, trouble talking, and trouble walking. It happens due to impaired coordination between muscles and nerves. Distinon Tablet makes this coordination between nerves and muscles better and relieves the symptoms. As a result, your muscle strength is improved and you are able to lead a better life.

In Paralytic ileus

Paralytic ileus is the obstruction of the intestines due to improper functioning of the nerves and muscles in the intestine that impairs digestive movement. Distinon Tablet induces contractions in the intestinal muscles and improves their function. As a result, there is better movement of food and this treats the obstruction. Take it as advised by the doctor and follow your doctor’s instructions carefully.

In Post-operative urinary retention

After an operation, there may be problems in emptying the bladder. This may be due to disturbed coordination of nerves and muscles of the bladder. Distinon Tablet helps to improve this problem and treats post-operative urinary retention effectively.

In Reversal of effect of skeletal muscle relaxant after surgery

Skeletal muscle relaxants are given to induce anesthesia and to carry out surgical or certain diagnostic procedures. This blocks the conduction of signals between nerves and muscles. After the surgery, Distinon Tablet is given to reverse this effect and cause muscle contraction again to restore normal function.

Side effects of Distinon Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Distinon

  • Nausea
  • Excessive salivation
  • Diarrhea
  • Blurred vision
  • Breathlessness
  • Watery eyes
  • Abdominal pain
  • Altered frequency of urination
  • Sweating
  • Headache
  • Dizziness
  • Runny nose
  • Heartburn
  • Gastro-esophageal reflux disease
  • Paresthesia (tingling or pricking sensation)
  • Muscle twitching
  • Weakness
  • Muscle cramp

How to use Distinon Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Distinon Tablet is to be taken empty stomach.

How Distinon Tablet works

Distinon Tablet increases the levels of acetylcholine (chemical messenger) which allows free transmission of signals across the nerves and muscles.

Safety Advice

It is not known whether it is safe to consume alcohol with Distinon Tablet. Please consult your doctor.
Distinon Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Distinon Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Distinon Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Distinon Tablet may reduce the sharpness of your eyesight and therefore your ability to drive or use machines. Do not drive or operate machines if this medicine affects your ability to see clearly.
Distinon Tablet should be used with caution in patients with kidney disease. Dose adjustment of Distinon Tablet may be needed. Please consult your doctor.
There is limited information available on the use of Distinon Tablet in patients with liver disease. Please consult your doctor.

What if you forget to take Distinon Tablet?

If you miss a dose of Distinon Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Distinon Tablet
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Mustone 60mg Tablet
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Pyristig 60mg Tablet
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Pyrido 60mg Tablet
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Pyodistig 60mg Tablet
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Quick Tips

  • You have been prescribed Distinon Tablet for treatment of myasthenia gravis.
  • It may also be used to treat inactivity of the muscle in the intestines (paralytic ileus) and difficulty in passing urine (urinary retention) after an operation.
  • Take it with food to avoid an upset stomach.
  • Take it as per the dose and duration advised by your doctor. Overdosing can result in extreme muscle weakness.
  • It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
  • Do not drink alcohol while taking this medicine as it may worsen the side effects.
  • Inform your doctor if you have an existing kidney problem, parkinson's disease, asthma, or stomach disorders.

Fact Box

Chemical Class
N-Methylpyridinium Compounds
Habit Forming
Therapeutic Class
Action Class
Cholinesterase inhibitors- carbamates

Patient Concerns

Drooping of eyelids. What is the cause of it? What is the remedy?
Dr. Vishal Maniar
At ur age u need detailed eye checkup and neurologist referenceTo rule out myasthenia gravis, ocular palsy Bells palsy,diabetes,trauma
Right medicine for myasthenia gravis
Dr. Vikas Sharma
many ; cant advise online as they are strong medicine
Do you have any questions related to Distinon Tablet ?

User Feedback


Q. Does Distinon Tablet cure myasthenia gravis? For how long do I need to take it?

Distinon Tablet helps reduce and improve muscle weakness and hence relieves the symptoms of myasthenia gravis but does not cure it. The length of time for which you have to take Distinon Tablet will depend on your needs. You should not stop taking Distinon Tablet until and unless advised by your doctor, even if you start feeling better.

Q. Will Distinon Tablet have any effect on my baby if I am breastfeeding?

A very small quantity of Distinon Tablet passes into breast milk, which may or may not affect your baby. Ask your doctor if you can continue to breastfeed your baby.

Q. Can I take Distinon Tablet for constipation?

No, Distinon Tablet should not be taken for any type of constipation. It is used only when constipation occurs due to paralysis of the intestine and strictly on prescription by the doctor.

Q. Who should not take Distinon Tablet?

Distinon Tablet should not be taken by patients who are allergic to it. It should also be avoided by patients who are constipated or cannot urinate, unless the doctor has advised to use this medicine. This is because Distinon Tablet is only used to treat certain types of constipation and inability to pass urine.

Q. What should I do if I have accidentally taken more than the required dose?

You should immediately seek help at a nearby hospital or contact your doctor urgently. An excess dose of Distinon Tablet may cause stomach pain, nausea, vomiting, diarrhea, excessive sweating, salivation, blurred vision, excessive weakness, difficulty in breathing, and even paralysis.

Q. Is Distinon Tablet a steroid?

No, Distinon Tablet is not a steroid. It belongs to anticholinesterases group of medicines. Distinon Tablet works by preventing the breakdown of a chemical called acetylcholine.

Q. Does Distinon Tablet have any abuse potential?

No, there is no evidence that Distinon Tablet has abuse potential.

Q. Does it cause weight gain?

No, Distinon Tablet does not cause weight gain. If you experience weight gain, it may be due to inactivity related to muscle weakness in myasthenia gravis.

Q. Is Distinon Tablet safe to use?

Yes, Distinon Tablet is safe if used according to the doctor’s advice. You should not exceed the dose as prescribed by the doctor.

Q. Is it safe to drive if I have taken Distinon Tablet?

Distinon Tablet may cause blurred vision, and therefore you should limit driving until you know how it affects you.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1172-73.
  2. Drugs.com. Pyridostigmine. (online) [Accessed 22 Mar. 2019] Available from:External Link
  3. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Pyridostigmine. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:External Link
  4. Pyridostigmine. Hertfordshire, UK: Mylan Products Limited; 1998 [revised 27 Feb. 2018]. [Accessed 22 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Country of Origin: India

Expires on or after: September, 2022

A licensed vendor partner from your nearest location will deliver Distinon Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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