Medicine Overview of Difen Injection
Side Effects of Difen are Vomiting, Stomach pain / epigastric pain, Nausea, Indigestion, Heartburn, Loss of appetite, Injection site reactions (pain, swelling, redness).
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Difen Injection is a non-steroidal anti-inflammatory drugs (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).
In Depth Information on Difen Injection
It should be taken with food or milk to avoid getting an upset stomach.
- It can cause serious complications like stomach bleeding and kidney problems if taken for a long time.
Difen Injection can raise a risk of blood clots, heart attack, or a stroke.
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
- Inform your doctor if you have ever been diagnosed with kidney or liver problems.
Difen Injection related warnings
Taking diclofenac with alcohol can increase your risk of stomach bleeding.
WEIGH RISKS VS BENEFITS
Difen Injection is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Difen Injection is probably safe to use during lactation.
Limited human data suggests that the drug does not represent a significant risk to the baby.
Do not drive unless you are feeling well.
Difen Injection may cause headaches, blurred vision, dizziness or drowsiness in some patients. This may affect your ability to drive.
Difen Injection should be used with caution in patients with kidney disease. Dose adjustment of Difen Injection may be needed. Please consult your doctor.
Difen Injection should be used with caution in patients with liver disease. Dose adjustment of Difen Injection may be needed. Please consult your doctor.
Regular monitoring of liver function tests is recommended in patients with liver disease if this medicine is to be taken for a long time.
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Frequently asked questions about Difen Injection
Q. Is diclofenac topical a blood thinner / controlled substance?
Diclofenac is a pain relieving medication and it does not significantly affect the function of platelets in blood; hence it is not a blood thinner. It is not a controlled substance as it does not have the potential for abuse or addiction.
Q. Can I use Difen along with vitamins?
Yes, Difen can be taken with vitamins. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Can Difen be used for the treatment of hepatitis?
No, Difen is not approved for the treatment of hepatitis. Hepatitis is a condition where the liver is inflamed. Difen can, in fact, cause harm to the liver as a side effect.
Q. Can Difen be used after C-section?
Yes, Difen is a pain killer. C-section is the short name for Cesarean Section which is an operative procedure to deliver the baby through the mother's abdomen and uterus. Difen can be used to treat the pain that may occur after the operation.
Q. Can I use Difen for the treatment of arthritis?
Yes, Difen is commonly used for the treatment of pain in osteoarthritis, rheumatoid arthritis, and spondylitis.It belongs to the class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). .
Q. Can I take Difen along with misoprostol?
Yes. It can be taken together. Misoprostol protects the stomach from irritating gastric effects of Difen. The combination of medication is used to treat arthritis in patients at high risk of getting stomach/intestinal ulcers and complications from the ulcers (such as bleeding).
Q. Can I take Difen while I am on thyroxine?
Yes, Difen can be taken with thyroxine. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Can I use Difen with diuretics?
No, Difen should not be used with diuretics. Difen reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
No, Difen is not a narcotic. Narcotics are drugs with sleep inducing properties, usual derivatives of Opium like Heroin and Morphine.
Q. Can Difen be used along with warfarin?
No. Using Difen together with warfarin can increase the risk of serious bleeding from the stomach (Higher than users of either drug alone). Inform your doctor before starting these medications.
Q. Why does Difen cause an ulcer?
Difen can cause damage to the lining cells of the stomach by several mechanisms, including the irritant effect on the cells, breaking of the protective barrier properties of lining cells, suppression of prostaglandin production of the stomach, reduction of stomach mucosal blood flow and interference with the repair of superficial injury of the stomach lining.
Q. Why is Difen contraindicated in asthma?
Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory drugs (NSAID) like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.
Q. Is Difen a painkiller?
Yes. Difen is a pain killer. In fact, it belongs to the class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). It is commonly used for the treatment of pain in osteoarthritis, rheumatoid arthritis and spondylitis.
Q. Is Difen good for back pain?
Yes, Difen has been found to be effective to reduce back pain. Difen is a pain killer that belongs to the NSAIDs (Non-Steroidal Anti-Inflammatory) class. Other NSAIDs have also been found to be useful in back pain eg. Ibuprofen and Naproxen.
Q. Why Difen should be stopped before surgery?
Since Difen has been shown to have blood thinning effects, it can increase the risk of bleeding. Therefore, it is stopped before surgery to prevent excessive loss of blood.
Q. Can I use Difen during my fever treatment?
Yes, Difen can reduce fever. However, commonly used to reduce the pain, particularly that which is seen with Osteoarthritis, Rheumatoid Arthritis and Ankylosing spondylitis.
Q. Can I use Difen to treat a sore throat?
Sore throat is mostly caused by bacteria so antibiotics are given to treat a sore throat whereas Difen is a pain killer so it can be given in cases of throat pain associated with it but only under the prescription of a doctor.
Q. What are the contraindications for Difen?
Difen should not be used if there is an allergic reaction (hypersensitivity) to it, or other pain killers, active ulcer in the stomach, bleeding from the stomach, history of severe heart failure, liver failure, kidney failure and or heart attack.
Q. Can I use Difen to treat urinary tract infections (UTI)?
Difen can be used to treat the pain associated with urinary tract infection (UTI) but for complete treatment, a course of antibiotics will be required.
Q. Can Difen cause sedation?
Difen is not known to cause sedation. There have been rare, an isolated case report of sedation with the drug.
Q. Can I take Difen for kidney stones?
Yes,Difen can be used to relieve the pain due to kidney stones. However, there is also a risk of kidney damage with Difen as its side effect. It is advised not to take Difen for a prolonged time for this condition without adequate monitoring.
Q. Can I use Difen with mifepristone?
These drugs should not be used together as the effect of mifepristone may be lowered by Difen. Mifepristone is used for medical abortion.
Q. Can I use Difen with lithium?
No.These drugs should not be used together as Difen increases the blood levels of lithium which may further increase the side effects.
Q. Can Difen affect the chance of conceiving?
Yes. Difen can sometime cause reversible infertility. Difen by its mechanism of action, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.
Severely interacts with other drugs like
Taking Difen with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Medicines with composition Oxyphenbutazone: Flanil, Sioril
Medicines with composition Nimesulide: Nimsun, Abinim, Nimulis, Neil, Zenee PR, Sanim, Renex, Nimoffin, Selide, Elide
Medicines with composition Benzydamine: Ready Rinse, Tantum, Mucobenz, B Mine, Garbenz, Coolora, Uvdyne, Biqol, Edel, Bzynice
Medicines with composition Metamizole / Dipyrone: Pyregin, Novalgin RC, Bral, Novalgin, Analgin, Divi A
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