Denfovir 300mg Tablet is used in the treatment of chronic hepatitis B virus (HBV) infection. It is also used to treat HIV infection in combination with other anti-HIV medicines. It prevents the multiplication of viruses in human cells. This stops the virus from producing new viruses and clears up your infection.

Denfovir 300mg Tablet is not a cure for HIV/AIDS and only helps to decrease the amount of HIV in your body. This helps to lower your risk of getting HIV-related complications and improves your lifespan. It may also be used to prevent HIV infection in some people at high risk. This medicine may be taken with or without food. It is used in combination with other anti-HIV medicines. Taking these medicines regularly at the right time greatly increases their effectiveness and reduces the chances of HIV becoming resistant to them. It is important not to miss doses and to keep taking them until your doctor tells you it is safe to stop.

Common side effects of this medicine include nausea, vomiting, diarrhea, flatulence, trouble sleeping, headache, and rash. These are usually not serious but inform your doctor if they bother you or will not go away. It can also increase the risk of bone loss (osteoporosis) if you take it for a long time. Exercise regularly and take calcium and vitamin D supplements as suggested by your doctor. Some people may put on weight while taking medicines to treat HIV/AIDS.

Before taking it, tell your doctor if you have any liver or kidney disease or bone problems. While taking it, you may need regular blood tests to check your blood counts, liver function, and kidney function. Since this medicine may cause dizziness or sleepiness, do not drive until you know how it affects you. Pregnant or breastfeeding mothers should consult their doctor before using this medicine. Do not have unprotected sex or share personal items like razors or toothbrushes, if you are HIV positive. Talk to your doctor about safe ways like condoms to prevent HIV transmission during sex.

Uses of Denfovir Tablet

Benefits of Denfovir Tablet

In Treatment of Chronic hepatitis B virus (HBV) infection

Chronic hepatitis B virus infection is a serious liver infection that has been there for at least 6 months and is still not cured. Denfovir 300mg Tablet helps treat this infection effectively. It lowers the chances of complications, such as new infections, and improves one’s quality of life. If this infection is not treated, it can lead to severe liver damage, which can cause other life-threatening problems, such as liver failure, or may be fatal also.

In Treatment of HIV infection

Denfovir 300mg Tablet, when used in combination with other anti-HIV medicines, prevents the HIV virus from multiplying in your body. It helps control the infection and makes your immune system work better. This lowers your chances of getting complications such as new infections and improves your quality of life. This medicine is always taken in combination with other antiretroviral medicines.

It is not a cure of HIV or AIDS and should not be used to prevent HIV after accidental exposure to a risk. It is important that you take this medicine as prescribed, following the dosage recommended by your doctor. Taking all doses in the right amount at the right times greatly increases the effectiveness of your combination of medicines and reduces the chances of your HIV infection becoming resistant to antiretroviral medicines. However, taking this medicine will not prevent you from passing HIV to other people.

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Side effects of Denfovir Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Denfovir

Diarrhea
Nausea
Rash
Weakness
Vomiting
Fatigue
Abdominal pain
Increased transaminase level in blood
Decreased phosphate level in blood
Pain
Dizziness
Depression
Insomnia (difficulty in sleeping)
Fever
Itching

How to use Denfovir Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Denfovir 300mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Denfovir Tablet works

Denfovir 300mg Tablet is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Denfovir 300mg Tablet. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Denfovir 300mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

SAFE IF PRESCRIBED

Denfovir 300mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving

UNSAFE

Denfovir 300mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Denfovir 300mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Denfovir 300mg Tablet may be needed. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

Denfovir 300mg Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Denfovir 300mg Tablet may not be needed in these patients. Please consult your doctor.

What if you forget to take Denfovir Tablet?

If you miss a dose of Denfovir 300mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Denfovir 300mg Tablet

₹42.8/Tablet

Tenohep Tablet

Zydus Cadila

₹37.53/tablet

12% cheaper

Ricovir 300mg Tablet

Mylan Pharmaceuticals Pvt Ltd - A Viatris Company

₹37.53/tablet

12% cheaper

Tenvir Tablet

Cipla Ltd

₹49.33/tablet

15% costlier

Tenof Tablet

Hetero Drugs Ltd

₹47.8/tablet

12% costlier

Rivofonet Tablet

Emcure Pharmaceuticals Ltd

₹44.9/tablet

5% costlier

View all substitutes

Quick tips

You have been prescribed Denfovir 300mg Tablet for the treatment of chronic hepatitis B virus (HBV) infection.
In combination with other medicines, it is used for the treatment of HIV infections.
Take it with food, as this increases the absorption of the medicine into the body.
Denfovir 300mg Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
You may still develop infections or other illnesses associated with viral infection while taking this medication.
You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus and blood cells in your blood.

Fact Box

Chemical Class

Adenine analog

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs)

Interaction with drugs

Taking Denfovir with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Amikacin (Injection Route) Severe

Concurrent use may increase the risk of kidney damage. Do not consume Tenofovir disoproxil fumarate with Amikacin. If concurrent use is essential, your doctor may monitor your kid... More

Amphotericin B (Injection Route) Severe

Concurrent use may increase the risk of kidney damage. Do not consume Tenofovir disoproxil fumarate with Amphotericin B. If concurrent use is essential, your doctor may monitor yo... More

Acyclovir (Injection Route) Severe

Concurrent use may increase the risk of kidney damage. Do not consume Tenofovir disoproxil fumarate with Acyclovir. If concurrent use is essential, your doctor may monitor your ki... More

Acyclovir (Oral Route) Severe

Concurrent use may increase the risk of kidney damage. Do not consume Tenofovir disoproxil fumarate with Acyclovir. If concurrent use is essential, your doctor may monitor your ki... More

Amphotericin B (Vaginal Route) Severe

Concurrent use may increase the risk of kidney damage. Do not consume Tenofovir disoproxil fumarate with Amphotericin B. If concurrent use is essential, your doctor may monitor yo... More

View all drug interactions

Patient concerns

What should be next course of action for me. Pls guide. I am about to be married and really scared.

Dr. Ila Jain Khandelwal

Pathology

Dear PATIENT from 1mg. The reports shows positive Hepatitis B surface antigen which can be due to Hepatitis B infection. I suggest you should consult a Hepatologist/ Gatroenetrologist/ Physician for this.

I M HBSAG ( HEPATITIS B POSITIVE) SO SIR any treatment treat my infection

Dr. Deepak Kumar Soni

Ayurveda

https://goo.gl/forms/5QhDt8ZurRhhcjvD2 Kindly fill the health information so that I can advice best products to you thanks

FAQs

Does Denfovir 300mg Tablet prevent passing of HIV-1 and HBV to others?

In case of HIV-1 infection, Denfovir 300mg Tablet may reduce the risk of passing the virus to others, but the chances of infecting others still persist. However, in case of HBV infection, Denfovir 300mg Tablet has not proven to reduce risk of transferring the virus to others. Therefore, the patients of both HIV-1 infection and HBV infection should practice safe sex and should not share dirty needles.

Is Denfovir 300mg Tablet safe?

Denfovir 300mg Tablet is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.

How should I take Denfovir 300mg Tablet?

You should take Denfovir 300mg Tablet in the dose and duration advised by your doctor. Denfovir 300mg Tablet works best when taken with meals or just afterwards. However, taking it without food does not reduce its effectiveness. If you have any doubts, consult your doctor.

For how long do I need to take Denfovir 300mg Tablet for HBV infection?

Duration of treatment will depend on the severity of HBV infection. You will need to take periodic blood tests to keep a check on the viral load and number of T cells. Your doctor will then decide the duration of the medicine accordingly. In some cases, treatment is required life long.

I vomited after taking Denfovir 300mg Tablet. What should I do?

Take another tablet of Denfovir 300mg Tablet if you vomit within 1 hour of taking it. If you vomit after more than an hour of taking Denfovir 300mg Tablet, then you need not take another tablet. Consult your doctor if you have vomiting every time you take Denfovir 300mg Tablet or if the vomiting persists for a longer duration.

What should I do if I forget to take Denfovir 300mg Tablet?

If you forget to take Denfovir 300mg Tablet within 12 hours of the time you usually take it, you should take Denfovir 300mg Tablet with food as soon as possible and resume the normal dosing schedule. If you miss a dose of Denfovir 300mg Tablet by more than 12 hours and it is almost time for the next dose, you should not take the missed dose and simply resume the usual dosing schedule.

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Related lab tests

HIV 1 & 2, Ab Western Blot

HIV 1 And 2 Antibody - Chromatography

HIV 1 And 2 Antibody - ELISA

Hepatitis B (Core) IgM Antibody

Hepatitis B s (Surface) Antigen

Hepatitis C Virus Total Antibody

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Safrin S. Antiviral Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 859-60.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1327-28.
Tenofovir disoproxil fumarate. Foster City, CA: Gilead Sciences, Inc; 2001 [revised Jan. 2012]. [Accessed 31 Mar. 2019] (online) Available from:
Tenofovir disoproxil. Limassol, Cyprus: Remedica Ltd.; 2018. [Accessed 24 Jan. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 31 Mar. 2019] (online) Available from:
CiplaMed. Tenofovir Disoproxil Fumarate [Prescriing Informataion]. [Accessed 07 Aug. 2023]. (online) Available from:
Tenofovir disoproxil fumarate [Prescribing Inforamtion]. Indiana, PA: Remedy Repack, Inc.; 2018. [Accessed 07 Aug. 2023]. (online) Available from:

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Country of origin: India

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