Defogen 1mg Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 22 Sep 2025 | 02:09 PM (IST)

Defogen 1mg Tablet is a female hormone that is identical to estrogen. It is used as a hormone replacement therapy (HRT) to treat symptoms associated with menopause (hot flushes, vaginal dryness and itching), estrogen deficiency (hypoestrogenism), and thinning of bones (osteoporosis).

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General Information

Contains

Estriol (1mg)

Marketer

Incepta Pharma

Storage

Store below 30°C

The content is shown in English

Product introduction

In some cases, Defogen 1mg Tablet is also used to treat breast cancer and prostate cancer along with other anticancer medicines. The medicine is to be swallowed with water. It can be taken with or without food, but remember to take it at a fixed time each day for better efficacy. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. If you have missed a dose, take it as soon as you remember it. Do not skip any dose and finish the full course of treatment. The treatment should not be stopped abruptly without consulting your doctor as this may affect the potency of this medicine.

The most common side effects of this HRT are headache, breast pain, irregular vaginal bleeding or spotting, abdominal cramps or bloating, nausea, vomiting, and hair loss. Some of the warning signs and symptoms that need immediate medical attention are breast lumps, unusual vaginal bleeding, dizziness and faintness, severe headaches, chest pain, shortness of breath, pains in your legs, etc.

Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same disease or other diseases. Before you initiate with this HRT, you must consult the doctor if you have a history of unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. If you are pregnant or breastfeeding, you should tell your doctor before taking this medicine. Your doctor may suggest you some diagnostic or laboratory tests to know the effects and side effects of this medicine on your body.

Uses of Defogen Tablet

Benefits of Defogen Tablet

Treatment of Prostate cancer
Prostate cancer is a common type of cancer in males, but it is highly treatable in the early stages. It starts in the prostate gland, which is located between the penis and the bladder. Defogen 1mg Tablet helps treat prostate cancer by decreasing or stopping the growth of cancer cells. This further gives relief from the symptoms of prostate cancer such as difficulty in passing urine. Take Defogen 1mg Tablet as prescribed by your doctor.

Hormone replacement therapy
Hormone placement therapy (HRT) is a treatment to relieve symptoms of menopause such as hot flushes, night sweats, mood swings, vaginal dryness, and reduced sex drive. Since menopause can last for several years, this treatment can make a big improvement to your daily life and mood. Estriol is an important hormone used in this treatment. You should use this medicine as it is prescribed, and for as long as it is prescribed by your doctor.

Prevention of Breast cancer
Defogen 1mg Tablet relieves the symptoms of breast cancer such as breast lumps, bloody discharge from the nipple or changes in the shape or texture of the breast. It works by altering the production of those hormones in the body that are essential for the growth and spread of breast cancer. It may also interact with other hormones or have a direct effect on cancer to stop its growth. It is given as an injection by a doctor or nurse and should not be self-administered. Follow your doctor’s instructions carefully.

Side effects of Defogen Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Defogen

Headache
Breast pain
Irregular vaginal bleeding
Abdominal cramp
Bloating
Hair loss
Nausea
Vomiting
Weight loss

How to use Defogen Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Defogen 1mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Defogen Tablet works

Defogen 1mg Tablet contains a hormone called estrogen (female sex hormone). It works by replacing estrogen that is normally produced by the body.

Quick tips

You have been prescribed Defogen 1mg Tablet as a part of hormone replacement therapy to relieve symptoms of menopause.
It may also be used for preventing osteoporosis in postmenopausal women who are at high risk of fractures.
Take it at the same time everyday to help you remember to take it.
Inform your doctor if you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort while taking Defogen 1mg Tablet.
It may increase the risk of breast cancer. Have regular breast examinations.
Stop taking this medicine and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision. These could be symptoms of a blood clot in a vein

Safety advice

Alcohol

CAUTION

Caution is advised when consuming alcohol with Defogen 1mg Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Defogen 1mg Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

UNSAFE

Defogen 1mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

SAFE

Defogen 1mg Tablet does not usually affect your ability to drive.

Kidney

CAUTION

Defogen 1mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Defogen 1mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Defogen 1mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Defogen 1mg Tablet may be needed. Please consult your doctor.

Interaction with drugs

Taking Defogen with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Tamoxifen (Oral Route)

Do not consume Tamoxifen with Estriol if you have or had breast cancer. If essential, consult your doctor. Estriol may reduce the efficacy of Tamoxifen.

Severe

Letrozole (Oral Route)

Do not consume Letrozole with Estriol if you have or had breast cancer. If essential, consult your doctor.

Severe

Fulvestrant (Injection Route)

Do not consume Fulvestrant with Estriol if you have or had breast cancer. If essential, consult your doctor. Estriol may reduce the efficacy of Fulvestrant.

Severe

Anastrozole (Oral Route)

Do not consume Anastrozole with Estriol if you have or had breast cancer. If essential, consult your doctor. Estriol may reduce the efficacy of Anastrozole.

Severe

Raloxifene (Oral Route)

Do not consume Raloxifene with Estriol. If concurrent use is essential, please consult your doctor. Estriol may reduce the efficacy of Raloxifene.

Frequently asked questions

What is Defogen 1mg Tablet and what is it used for?

Defogen 1mg Tablet tablet contains a medicine called Estriol which is an estrogen hormone. It helps in treating estrogen deficiency symptoms like hot flushes (red and warm face), vaginal dryness in women. It is also used to prevent osteoporosis (thinning and weakening of bone) in postmenopausal women, who are at high risk of fractures and can not take other preventive medicines for osteoporosis.

When and how to take Defogen 1mg Tablet?

Take Defogen 1mg Tablet as per the advise by your doctor. However, you must try to take Defogen 1mg Tablet tablet at the same time of each day, to ensure the consistent levels of medicine in your body.

What if I miss to take Defogen 1mg Tablet?

If you miss a dose, you should take it as soon as possible. If the dose was missed by more than 12 hours, you should not take the missed dose and simply continue the usual dosing schedule.

What are the most common side effects which I may experience while taking Defogen 1mg Tablet?

The common side effects associated with Defogen 1mg Tablet are lower abdominal pain, periods pain, breast tenderness, endometrial hyperplasia (thickening of uterus lining) and vaginal discharge. Most of these symptoms are temporary. However, if they persist, check with your doctor as soon as possible.

Fact Box

Chemical Class

Estrogens Derivatives

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Action Class

Estrogens

Related lab tests

Breast Cancer (CA 15.3/ ER/ PR)

Prostate Specific Antigen (Free) PSA

Prostate Specific Antigen (Total) PSA

References

Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 701-702.
ScienceDirect. Estriol. [Accessed 03 Apr. 2019] (online) Available from:
Estriol [Prescribing Information]. Madison, NJ: Intervet International B.V.; 2020. [Accessed 10 June 2024] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Incepta Pharma
Address: Parshvnath Tower, Subhash Chowk, Mem Nagar, Ahmedabad-302002 (Gujarat)

Vendor Details

Country of origin: India

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Defogen 1mg Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Defogen Tablet

Benefits of Defogen Tablet

Side effects of Defogen Tablet

How to use Defogen Tablet

How Defogen Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Tamoxifen (Oral Route)

Letrozole (Oral Route)

Fulvestrant (Injection Route)

Anastrozole (Oral Route)

Raloxifene (Oral Route)

Frequently asked questions

What is Defogen 1mg Tablet and what is it used for?

When and how to take Defogen 1mg Tablet?

What if I miss to take Defogen 1mg Tablet?

What are the most common side effects which I may experience while taking Defogen 1mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Breast Cancer (CA 15.3/ ER/ PR)

Prostate Specific Antigen (Free) PSA

Prostate Specific Antigen (Total) PSA

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests