Busuphan 2mg Tablet
Prescription Required
Product introduction
Busuphan 2mg Tablet is used in the treatment of some cancers of blood like chronic myeloid leukaemia. It is used in combination with other cancer medicines during hematopoietic progenitor cell transplantation (HPCT). It may also be used to treat some other types of cancer.
Busuphan 2mg Tablet can be taken with or without food, but better to take it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include decreased blood cells (red cells, white cells, and platelets), nausea, vomiting, and loss of appetite. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.
Inform your doctor if you have a medical history, of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Busuphan 2mg Tablet can be taken with or without food, but better to take it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include decreased blood cells (red cells, white cells, and platelets), nausea, vomiting, and loss of appetite. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.
Inform your doctor if you have a medical history, of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Busuphan Tablet
Benefits of Busuphan Tablet
In Blood cancer (Chronic myeloid leukaemia)
Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Busuphan 2mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
Side effects of Busuphan Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Busuphan
- Decreased blood cells (red cells, white cells, and platelets)
- Abdominal pain
- Anxiety
- Nausea
- Vomiting
- Loss of appetite
- Decreased magnesium level in blood
- Decreased potassium level in blood
- Diarrhea
- Fever
- Headache
- Increased glucose level in blood
- Insomnia (difficulty in sleeping)
- Stomatitis (Inflammation of the mouth)
How to use Busuphan Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Busuphan 2mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Busuphan Tablet works
Busuphan 2mg Tablet is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Busuphan 2mg Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Busuphan 2mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
UNSAFE
Busuphan 2mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
CONSULT YOUR DOCTOR
It is not known whether Busuphan 2mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
SAFE IF PRESCRIBED
Busuphan 2mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Busuphan 2mg Tablet may not be needed in these patients. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Busuphan 2mg Tablet in patients with liver disease. Please consult your doctor.
What if you forget to take Busuphan Tablet?
If you miss a dose of Busuphan 2mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
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Quick tips
- Take it at a same time every day, either with food or without food.
- Do not skip any dose and complete the course as suggested by your doctor.
- Use an effective method of birth control to avoid pregnancy while taking this medication.
- Your doctor may get regular blood tests done to monitor the levels of blood cells in your blood.
- Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat.
Fact Box
Chemical Class
Organosulfonic Acid Esters Derivative {Alkylating Agent
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Alkylating agent
Interaction with drugs
Taking Busuphan with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Busulfan from 1 day before until 1 day after taking Molgramostim. Plea
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Busulfan from 1 day before until 1 day after taking Sargramostim. Plea
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Busulfan from 14 days before until 24 days after taking Pegfilgrastim.
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytot
Concomitant use may increase the risk of opportunistic infections.
Do not consume Natalizumab with Busulfan.
Patient concerns
FAQs
Does Busuphan 2mg Tablet cause hair loss?
Yes, Busuphan 2mg Tablet can cause hair loss.
Is Busuphan 2mg Tablet a vesicant?
Yes. Busuphan 2mg Tablet is a vesicant (irritant).
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1685-86.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 171-72.
- Drugs.com. Busulfan Pregnancy and Breastfeeding Warnings. [Accessed 26 Mar. 2019] (online) Available from:
- Busulfan. Ireland: Aspen Pharma Trading Limited; 13 Jan. 1986 [revised Sep. 2017]. [Accessed 26 Mar. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Busulfan. [Updated 2018 Oct 31]. [Accessed 18 Feb. 2020] (online) Available from:
Marketer details
Name: Elder Pharmaceuticals Ltd
Address: “Elder House” Plot No. C-9, Dalia Industrial Estate, Off Veera Desai Road, Andheri (W), Mumbai – 400053.
Country of origin: India
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