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MD (Pharmacology), MBBS
Last updated:
18 Feb 2020 | 05:25 PM (IST)
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Bosentas 62.5 Tablet

Prescription Required
Manufacturer
SALT COMPOSITION
Storage
Store at room temperature (10-30°C)
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Overview

Introduction

Bosentas 62.5 Tablet is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It even helps to improve your quality of life, exercising ability and delay in disease progression.

Bosentas 62.5 Tablet should be taken with or without food. This medicine should be used regularly to get the most benefit from it. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you.

The most common side effects of this medicine include headache, swelling of the legs and ankles, and diarrhea.  If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some serious side effects which mean your doctor should know immediately include Anemia (low number of red blood cells) and abnormal liver function such as nausea, vomiting, dark urine, fever, and dark urine. Your doctor might check you for blood tests to check for anemia and liver function.

Before taking this medicine, let your doctor know if you have liver dysfunctioning. Inform your doctor if you are pregnant or breastfeeding. Women are suggested to use reliable contraceptive pills to avoid pregnancy and should continue even after one month of stopping the treatment. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.

Side effects of Bosentas Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Bosentas

  • Headache
  • Ankle swelling
  • Edema (swelling)
  • Diarrhea
  • Anemia (low number of red blood cells)
  • Respiratory tract infection

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Headache
    Make sure you rest and drink plenty of fluids. Rest in a quiet, dimly lit room. Do not sleep more than you normally would. Do not strain your eyes (for example by looking at a screen). Do not drink alcohol. Headaches are usually temporary and usually go away with time. But, if they last longer or get worse, ask your doctor to recommend a painkiller.
  • Coping with Ankle swelling
    Keep your legs raised when you are sitting or lying down. Try to keep moving your legs and ankles by taking a short walk several times an hour, as standing still for too long can increase swelling. Avoid wearing tight-fitting clothes and do not cross your leg. Drink plenty of non-alcoholic fluids and avoid alcohol. Reduce the salt in your diet. Losing weight and performing leg exercises while sitting can also help reduce the swelling. Using compression socks may help relieve pain and prevent fluid collection in your legs, ankles and feet.
  • Coping with Diarrhea
    Keep up your intake of fluids and electrolytes (sugars and salts) to avoid getting dehydrated. Eat less fiber (avoid raw fruits, fruit juice and vegetables). Talk to your doctor about possible medication to manage diarrhea. Ask about reducing the dosage of your drug or other suitable treatments.
  • Coping with Anemia (low number of red blood cells)
    Making some simple lifestyle changes can raise your red blood cell count. Reduce the amount of alcohol you drink, eat a well-balanced healthy diet and take regular exercise. Physical activities make your body need more oxygen and this stimulates the production of red blood cells. There are some vitamins which are important such as vitamin B-12, vitamin B-9, vitamin C and Vitamin A. Also, some minerals such as iron (especially) and copper. Aim for foods which contain higher quantities of these vitamins and minerals or ask your doctor for supplements. Make sure to consult your doctor for complete evaluation and treatment of anemia.

How to use Bosentas Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Bosentas 62.5 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Bosentas Tablet works

Bosentas 62.5 Tablet is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Bosentas 62.5 Tablet helps relax these blood vessels and increases the supply of blood to the lungs.

Safety Advice

Alcohol
UNSAFE
Bosentas 62.5 Tablet may cause excessive drowsiness with alcohol.
Pregnancy
UNSAFE
Bosentas 62.5 Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breastfeeding
CONSULT YOUR DOCTOR
Bosentas 62.5 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Bosentas 62.5 Tablet may cause side effects which could affect your ability to drive.
As Bosentas 62.5 Tablet can induce hypotension (decrease of your blood pressure) which can make you feel dizzy and this can affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Bosentas 62.5 Tablet is safe to use in patients with kidney disease. No dose adjustment of Bosentas 62.5 Tablet is recommended.
Liver
CAUTION
Bosentas 62.5 Tablet should be used with caution in patients with liver disease. Dose adjustment of Bosentas 62.5 Tablet may be needed. Please consult your doctor.
Use of Bosentas 62.5 Tablet is not recommended in patients with moderate and severe liver disease.

What if you forget to take Bosentas Tablet?

If you miss a dose of Bosentas 62.5 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Bosentas 62.5 Tablet
₹83.84/Tablet
PULVANCE 62.5 MG TABLET
Sun Pharmaceutical Industries Ltd
₹69/Tablet
save 18%
₹69.48/Tablet
save 17%
Bosenat 62.5 Tablet
Natco Pharma Ltd
₹73/Tablet
save 13%
₹111.2/Tablet
33% costlier

Quick Tips

  • Your doctor has prescribed Bosentas 62.5 Tablet to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
  • It helps improve your quality of life, exercising ability, and delay disease progression.
  • Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
  • Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
  • Do not drive or do anything requiring concentration until you know how Bosentas 62.5 Tablet affects you.
  • Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Bosentas 62.5 Tablet as it is toxic to an unborn baby.
  • Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
  • Inform your doctor if you notice yellowing of skin/eye, dark urine, or stomach pain.

Fact Box

Chemical Class
Sulfonamide and Pyrimidine Derivative
Habit Forming
No

Interaction with Drugs

Taking Bosentas with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Clowil, Odis, Kamestin
LIFE-THREATENING
Brand(s): Fungis, EF Z, Rocflu
LIFE-THREATENING
Brand(s): No Gluco, Diabnil, D Con
LIFE-THREATENING
Brand(s): Indizole
LIFE-THREATENING

Patient Concerns

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sir i m suffering from PAH problem as my doctor says what is better for me to do as i m taking a medicine bosentas 62.5 and sildenafil tab. PAH 20 since 1 year what is the better way to get rid of this medicines
Dr. Nabajit Talukdar
Cardiology
Need to see you can meet me at medanta. Call 9XXXXXX
Bosentas tab and glybovin 1.25( glebenclamide) isnt same drug If not please check search machine to 1mg
Dr. Anshum Aneja Arora
Pulmonology
Yes bosentas tab is completely different . Do not confuse between the two meds . You can notify 1 mg support
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Do you have any questions related to Bosentas 62.5 Tablet ?

User Feedback


FAQs

Q. How is Bosentas administered?

Bosentas is given as a tablet form and can be taken with or without food. The tablets are to be taken twice daily in the morning and evening. The exact dosage and frequency of dose will be decided by the doctor on the basis of age and weight of the patient.

Q. Are there chances of anemia with Bosentas?

Yes, there are chances that Bosentas may cause anemia. It can cause a dose-related decrease in hemoglobin in the blood which could lead to anemia. Regular hemoglobin check is advised while taking this medicine and consult your prescribing doctor for his advice. In some cases, blood transfusion is done to treat anemia.

Q. Can I take Bosentas if I have liver problems?

It has been found that in some cases Bosentas can cause liver damage in patients who are prone to have liver disease. This medicine can also lead to increased liver enzymes. Hence, it should be used with caution in prone patients or in patients with history of liver disease. Before starting the medication inform your doctor if you have had a history of liver disease.

Q. Is Bosentas safe in pregnancy?

No, Bosentas is not safe during pregnancy. There is evidence to show that it can cause major birth defects in the newborn baby and can harm the baby in womb. It is not advised to take Bosentas if you are planning to become pregnant. You should use reliable contraception methods while you take Bosentas. Consult your doctor before starting this medication or planning pregnancy.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Barnes PJ. Pulmonary Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1059.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 154-56.
  3. Bosentan. Beerse Belgium: Janssen-Cilag International NV; 2013 [revised Sep. 2018]. [Accessed 01 Apr. 2019] (online) Available from:External Link
  4. Bosentan. South San Francisco, California: Actelion Pharmaceuticals US, Inc.; 2001 [revised Aug. 2009]. [Accessed 23 Jan. 2019] (online) Available from:External Link
  5. Bosentan. South San Francisco, CA: Actelion Pharmaceuticals; 2001. [Accessed 01 Apr. 2019] (online) available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
A licensed vendor partner from your nearest location will deliver Bosentas 62.5 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
MRP838.44  Get 15% OFF
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₹712.67
10 tablets in 1 strip
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Estimated delivery by Friday, Aug 7
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