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atRest 25 Tablet

Tetrabenazine (25mg)

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atRest 25 Tablet is used to treat chorea (which is a movement disorder characterized by involuntary, jerky movements) associated with Huntington's disease. It reduces movements and improves function. This makes it easier for the person to move and function better.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 22 Apr 2026 | 11:48 AM (IST)

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10 tablets

Gurgaon

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General Information

Contains

Tetrabenazine (25mg)

Marketer

Centaur Pharmaceuticals Pvt Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

atRest 25 Tablet should be taken with or without food. However, it is advised to take it at the same time each day, as this helps maintain a consistent level of medicine in the body. Take this in the dose and duration as advised by your doctor. This medication must not be stopped suddenly without talking to your doctor, as it may worsen your symptoms.

Some common side effects of this medicine include nausea, insomnia (difficulty sleeping), anxiety, fatigue, akathisia (restlessness and inability to stay still), and depression. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts while taking this medicine.

Stop taking this medicine immediately if you have a fever, stiff muscles, confusion, or seizures (signs of neuroleptic malignant syndrome). Let your doctor know if you have any medical conditions. Let your doctor also know about all the medications you are taking, as some medicines may interact with atRest 25 Tablet. Pregnant or breastfeeding women should consult their doctor before taking atRest 25 Tablet to ensure safety.

Uses of atRest Tablet

Huntington's disease

Benefits of atRest Tablet

Huntington's disease
atRest 25 Tablet is used to manage involuntary movements (chorea) associated with Huntington’s disease. It helps reduce sudden jerking or twitching motions, improving movement control and supporting better daily functioning and comfort.

Side effects of atRest Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of atRest

Nausea
Insomnia (difficulty in sleeping)
Anxiety
Fatigue
Sleepiness
Akathisia (inability to stay still)
Depression
Agitation

How to use atRest Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. atRest 25 Tablet may be taken with or without food.

How atRest Tablet works

atRest 25 Tablet works by reducing extra dopamine levels in the brain. Dopamine is a chemical that controls movement, and too much of it can cause involuntary, jerky movements seen in Huntington’s disease. Balancing dopamine helps calm these movements, making it easier to control body motions and perform daily activities.

All substitutes for atRest 25 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Be cautious while driving or doing anything that requires concentration, as atRest 25 Tablet can cause dizziness and sleepiness.
Inform your doctor if you experience high fever, sweating, muscle stiffness, and faster breathing. These may be due to a rare side effect known as neuroleptic malignant syndrome.
Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Do not stop taking atRest 25 Tablet without talking to your doctor first, as it may cause worsening of symptoms.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking atRest 25 Tablet.

Pregnancy

CONSULT YOUR DOCTOR

atRest 25 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

atRest 25 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

atRest 25 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of atRest 25 Tablet in patients with kidney disease. Please consult your doctor.
However, caution is advised in these patients.

Liver

UNSAFE

atRest 25 Tablet is unsafe to use in patients with liver disease and should be avoided.

Interaction with drugs

Taking atRest with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Voriconazole (Oral Route)

Do not consume Voriconazole with Tetrabenazine.

Life-threatening

Fluconazole (Oral Route)

Do not consume Fluconazole with Tetrabenazine.

Life-threatening

Efavirenz (Oral Route)

Do not consume Efavirenz with Tetrabenazine.

Life-threatening

Voriconazole (Injection Route)

Do not consume Voriconazole with Tetrabenazine.

Life-threatening

Amiodarone (Oral Route)

Do not consume Tetrabenazine with Amiodarone.

Frequently asked questions

Is atRest 25 Tablet an antipsychotic?

atRest 25 Tablet is not an antipsychotic. It belongs to the vesicular monoamine transporter 2 (VMAT2) inhibitor class of medicines. It works by changing the activity of some natural substances in the brain that affect muscles and nerves.

What is the most important information that I should know about atRest 25 Tablet?

atRest 25 Tablet may increase the risk of depression or suicidal thoughts in patients with Huntington’s disease. Huntington’s disease is an inherited disease that causes the progressive breakdown of nerve cells in the brain. Therefore, you should not take atRest 25 Tablet if you have Huntington’s disease along with depression.

What should I avoid while taking atRest 25 Tablet?

Sleepiness is a common side effect of atRest 25 Tablet. Therefore, you should avoid driving or operating heavy machinery if you feel sleepy while taking atRest 25 Tablet.

Can I stop taking atRest 25 Tablet on my own?

No, you should not stop taking atRest 25 Tablet suddenly, without talking to your doctor. Sudden discontinuation of the medicine may cause neuroleptic malignant syndrome. This can be characterized by high fever, stiff muscles, confusion, hallucinations, increased sweating, and very fast or uneven heartbeat. Hence, to avoid such side effects, your doctor will gradually reduce your dose.

Can I take alcohol while on atRest 25 Tablet?

You should avoid alcohol since it may add to the sleepiness caused by atRest 25 Tablet. Similarly, you should avoid taking medicines that cause sleepiness. If you are not sure about the effects of the medicine, consult with your doctor.

Does atRest 25 Tablet affect blood pressure?

Yes, atRest 25 Tablet may affect blood pressure. In some patients, it may lower blood pressure. Along with that, one may experience dizziness, lightheadedness, and fainting while getting up quickly from a lying position (orthostatic hypotension). To avoid this problem, get out of bed slowly and rest your feet on the floor for a few minutes before standing up.

Fact Box

Chemical Class

Tetrahydroisoquinolines

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors

References

Aminoff MJ. Pharmacologic Management of Parkinsonism & Other Movement Disorders. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 480.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1337-38.
Tetrabenazine [Prescribing Information]. Washington, DC: Prestwick Pharmaceutical; 2008. [Accessed 19 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
Tetrabenazine [Product Label]. Centuar Pharma. [Accessed 07 Aug. 2023]. (online) Available from:
Tetrabenazine [Prescribing Information]. Princeton, NJ: Dr. Reddy’s Laboratories Inc.; 2020. [Accessed 13 Mar. 2025] (online) Available from:

User feedback

Patients taking atRest 25 Tablet

Twice A Day

52%

Once A Day

28%

Thrice A Day

20%

What are you using atRest Tablet for?

Huntington's disease

75%

Others

25%

How much was the improvement?

Excellent

40%

Poor

33%

Average

27%

What were the side-effects while using atRest 25 Tablet?

No Side Effect

67%

Nausea

33%

How do you take atRest Tablet?

With food

100%

Please rate atRest 25 Tablet on price

Expensive

83%

Average

17%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Centaur Pharmaceuticals Pvt Ltd
Address: CENTAUR HOUSE, Near Grand Hyatt, Vakola ,Santacruz – East, Mumbai – 400 055, India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver atRest 25 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

atRest 25 Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of atRest Tablet

Benefits of atRest Tablet

Side effects of atRest Tablet

How to use atRest Tablet

How atRest Tablet works

All substitutes for atRest 25 Tablet

Revocon Tablet

Ticstop Tablet

Ticstop 25mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Voriconazole (Oral Route)

Fluconazole (Oral Route)

Efavirenz (Oral Route)

Voriconazole (Injection Route)

Amiodarone (Oral Route)

Frequently asked questions

Is atRest 25 Tablet an antipsychotic?

What is the most important information that I should know about atRest 25 Tablet?

What should I avoid while taking atRest 25 Tablet?

Can I stop taking atRest 25 Tablet on my own?

Can I take alcohol while on atRest 25 Tablet?

Does atRest 25 Tablet affect blood pressure?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking atRest 25 Tablet

What are you using atRest Tablet for?

How much was the improvement?

What were the side-effects while using atRest 25 Tablet?

How do you take atRest Tablet?

Please rate atRest 25 Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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