Atrest 25 Tablet

Prescription Required

Introduction

Atrest 25 Tablet is used to treat Huntington's disease, a condition in which nerve cells in the brain breakdown over time, thus deteriorating the person’s physical and mental abilities. It also helps to relieve uncontrollable and jerky movements of the body.

Atrest 25 Tablet should be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. This medication mustn't be stopped suddenly without talking to your doctor as it may worsen your symptoms. However, discontinue this medicine immediately if you experience neuroleptic malignant syndrome, characterized by fever, muscle rigidity, and altered consciousness or seizures.

Some common side effects of this medicine include nausea, insomnia(difficulty sleeping), anxiety, fatigue, akathisia (restlessness and inability to stay still), and depression. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts while taking this medicine.

Uses of Atrest Tablet

Benefits of Atrest Tablet

In Huntington's disease

Huntington’s disease is a rare inherited disease that results in the death of nerve cells in the brain. As a result, there are problems with mental as well as physical functions. The affected person has coordination issues, impaired thinking, uncontrollable movements etc. Atrest 25 Tablet helps to treat these symptoms and also controls these jerky movements. This medicine can therefore enhance the quality of life by improving the ability to carry out daily functions in a better manner.

Side effects of Atrest Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Atrest

  • Nausea
  • Insomnia (difficulty in sleeping)
  • Anxiety
  • Fatigue
  • Sleepiness
  • Akathisia (inability to stay still)
  • Depression

How to use Atrest Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Atrest 25 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Atrest Tablet works

Atrest 25 Tablet works by depleting the stores of certain chemical messengers in the brain that helps in controlling body movements.

Safety advice

Alcohol
UNSAFE
Atrest 25 Tablet may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Atrest 25 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Atrest 25 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Atrest 25 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Atrest 25 Tablet in patients with kidney disease. Please consult your doctor.
However, caution is advised in these patients.
Liver
UNSAFE
Atrest 25 Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Atrest 25 Tablet
₹28.74/Tablet
Ticstop Tablet
Intas Pharmaceuticals Ltd
₹32.1/tablet
12% costlier
Revocon Tablet
Sun Pharmaceutical Industries Ltd
₹34.1/tablet
19% costlier

Quick tips

  • You have been prescribed Atrest 25 Tablet to help control movement disorders such as in Huntington’s disease.
  • Be cautious while driving or doing anything that requires concentration as Atrest 25 Tablet can cause dizziness and sleepiness.
  • Inform your doctor if you experience symptoms such as high fever, sweating, muscle stiffness, and faster breathing. These may be due to a rare side effect known as the neuroleptic malignant syndrome.
  • Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
  • Do not stop taking Atrest 25 Tablet without talking  to your doctor first as it may cause worsening of symptoms.

Fact Box

Chemical Class
Tetrahydroisoquinoline Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Monoamine depletor- Tetrabenazine

Patient concerns

arrow
The patient ;my uncle, is effected by Huntington's chorea. Please tell me few tips to control the involuntary movements and other problems in it like elevated moods, insomnia , violent behavior etc. Thank you
Dr. Vikas Sharma
Neurology
Needs medicine under medical supervision Deal with him calmly
I grind my teeth in sleep. What should i do?
Dr. Jyoti Kapoor Madan
Psychiatry
Grinding your teeth or bruxism is a sleep related movement disorder.Doctors don't completely understand what causes bruxism. Possible physical or psychological causes may include: Emotions, such as anxiety, stress, anger, frustration or tension Aggressive, competitive or hyperactive personality type Abnormal alignment of upper and lower teeth (malocclusion) Other sleep problems, such as sleep apnea Response to pain from an earache or teething (in children) Stomach acid reflux into the esophagus An uncommon side effect of some psychiatric medications, such as phenothiazines or certain antidepressants A coping strategy or focusing habit Complication resulting from a disorder such as Huntington's disease or Parkinson's diseaseIn case it is causing damage to your teeth , visit a dentist.In case you have headache, facial pain, get a psychiatric evaluation
arrow

User feedback


FAQs

Q. Can Atrest 25 Tablet be crushed?

No, Atrest 25 Tablet should not be crushed, cut, or chewed. It needs to be swallowed as a whole. But if you cannot swallow the whole tablet, tell your doctor who will probably prescribe you another medicine.

Q. Is Atrest 25 Tablet an antipsychotic?

Atrest 25 Tablet is not an antipsychotic. It belongs to the vesicular monoamine transporter 2 (VMAT2) inhibitor class of medicines. It works by changing the activity of some natural substances in the brain that affect muscles and nerves.

Q. What is the most important information that I should know about Atrest 25 Tablet?

Atrest 25 Tablet may increase the risk of depression or suicidal thoughts in patients with Huntington’s disease. Huntington’s disease is an inherited disease that causes the progressive breakdown of nerve cells in the brain. Therefore, you should not take Atrest 25 Tablet if you have Huntington’s disease along with depression.

Q. What should I avoid while taking Atrest 25 Tablet?

Sleepiness is a common side effect of Atrest 25 Tablet. Therefore, you should avoid driving or operating heavy machinery if you feel sleepy while taking Atrest 25 Tablet.

Q. Can I stop taking Atrest 25 Tablet on my own?

No, you should not stop taking Atrest 25 Tablet suddenly, without talking to your doctor. Sudden discontinuation of the medicine may cause neuroleptic malignant syndrome. This can be characterized by high fever, stiff muscles, confusion, hallucinations, increased sweating, and very fast or uneven heart beat. Hence, to avoid such side effects your doctor will gradually reduce your dose.

Q. Can I take alcohol while on Atrest 25 Tablet?

You should avoid alcohol since it may add to the sleepiness caused by Atrest 25 Tablet. Similarly, you should avoid taking medicines which cause sleepiness. If you are not sure about the effects of the medicine, consult with your doctor.

Q. Does Atrest 25 Tablet affect blood pressure?

Yes, Atrest 25 Tablet may affect the blood pressure. In some patients it may decrease the levels of blood pressure. Along with that, one may experience dizziness, lightheadedness, and fainting while getting up quickly from a lying position (orthostatic hypotension). To avoid this problem, get out of bed slowly, rest your feet on the floor for a few minutes before standing up.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Aminoff MJ. Pharmacologic Management of Parkinsonism & Other Movement Disorders. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 480.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1337-38.
  3. Tetrabenazine. Washington, DC: Prestwick Pharmaceutical; 2008. [Accessed 19 Mar. 2019] (online) Available from:External Link
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer address

CENTAUR HOUSE, Near Grand Hyatt, Vakola ,Santacruz – East, Mumbai – 400 055, India.
Country of origin: India

Expires on or after: February, 2023

A licensed vendor partner from your nearest location will deliver Atrest 25 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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