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Asginase 5000IU Injection

L-Asparaginase (5000IU)

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Stored between 2-8°C

Asginase 5000IU Injection is an anticancer medicine used in combination with other chemotherapy medicines to treat acute lymphoblastic leukemia (ALL), a type of blood cancer that affects white blood cells. It helps destroy abnormal leukemia cells and supports the continuation of planned chemotherapy treatment.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 14 Oct 2026 | 02:04 PM (IST)

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L-Asparaginase (5000IU)

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General Information

Contains

L-Asparaginase (5000IU)

Marketer

Sun Pharmaceutical Industries Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Asginase 5000IU Injection is given as an injection into a muscle or as an intravenous infusion (drip) under the supervision of a healthcare professional. Your doctor will determine the dose and treatment schedule based on your body size, condition, and response to treatment. Regular monitoring is required to assess how well the medicine is working and identify any side effects. Do not miss scheduled treatment appointments or stop treatment without consulting your doctor.

Common side effects of this medicine include nausea, vomiting, diarrhea, abdominal pain, fatigue, and decreased appetite. It may also cause increased blood sugar levels, liver problems, and inflammation of the pancreas (pancreatitis). Your doctor will monitor your blood sugar levels, liver function, and pancreatic function during treatment. Inform your doctor immediately if you experience severe abdominal pain, persistent vomiting, or unusual symptoms.

Asginase 5000IU Injection may cause serious allergic reactions, bleeding problems, or blood clots. Inform your doctor if you have previously experienced severe allergic reactions, pancreatitis, blood clots, or serious bleeding during asparaginase treatment. Seek immediate medical attention if you develop breathing difficulties, swelling of the face, unusual bleeding, or sudden chest pain.

Before receiving this medicine, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Both men and women should use effective contraception during treatment and for at least 3 months after the last dose. Breastfeeding should be avoided during treatment and for 2 weeks after the last dose.

Uses of Asginase Injection

Blood cancer (Acute lymphocytic leukemia)

Benefits of Asginase Injection

Blood cancer (Acute lymphocytic leukemia)
Acute lymphocytic leukemia (ALL) is a type of blood cancer in which abnormal white blood cells multiply rapidly and interfere with the production of healthy blood cells. Asginase 5000IU Injection is an anticancer medicine used alongside other chemotherapy medicines to help destroy these abnormal cells and control the disease. It plays an important role in combination chemotherapy and helps patients continue their planned treatment.

Side effects of Asginase Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Asginase

Vomiting
Febrile neutropenia
Nausea
Increased transaminase level in blood
Abdominal pain
Increased white blood cell count
Diarrhea
Decreased white blood cell count (lymphocytes)

How to use Asginase Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Asginase Injection works

Asginase 5000IU Injection is an anticancer enzyme that works by breaking down asparagine, an amino acid essential for the growth and survival of leukemia cells. These cancer cells cannot produce enough asparagine on their own and depend on an external supply. Reducing the availability of asparagine causes the leukemia cells to die, helping control the growth of cancer.

All substitutes for Asginase 5000IU Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Asginase 5000IU Injection is given as an injection into a muscle or as an intravenous infusion by a healthcare professional. Attend all scheduled appointments to avoid interruptions in your chemotherapy treatment.
Report severe or persistent abdominal pain, especially if accompanied by nausea, vomiting, or back pain. These symptoms may indicate inflammation of the pancreas (pancreatitis).
Get your blood sugar levels checked regularly, as Asginase 5000IU Injection may cause high blood sugar. Inform your doctor if you experience unusual thirst, frequent urination, or other symptoms of high blood sugar.
Attend regular blood tests to monitor your liver function and pancreatic health. These tests help your doctor identify potential side effects and manage them promptly.
Avoid driving or operating heavy machinery if you experience nausea, headache, or feel unwell after receiving the medicine.
Both men and women should use effective contraception during treatment and for at least 3 months after the last dose. Women should discuss suitable non-hormonal contraceptive methods with their doctor.
Avoid breastfeeding during treatment and for at least 2 weeks after the last dose, as the medicine may pose a risk to the breastfed baby.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Asginase 5000IU Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Asginase 5000IU Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Asginase 5000IU Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Asginase 5000IU Injection may cause side effects that could affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Asginase 5000IU Injection is safe to use in patients with kidney disease. No dose adjustment is recommended.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Asginase 5000IU Injection in patients with liver disease.
It should not be used in severe liver impairment.

Interaction with drugs

Taking Asginase with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Imatinib mesylate (Oral Route)

If concurrent use is essential, your doctor may monitor your liver function frequently.

Moderate

Acarbose (Oral Route)

Your doctor may monitor your diabetic control closely and adjust the doses as per the observations.

Moderate

Alogliptin (Oral Route)

Your doctor may monitor your diabetic control closely and adjust the doses as per the observations.

Moderate

Bemiparin (Injection Route)

If concurrent use is essential, watch out for symptoms such as fatigue, nausea, loss of appetite, dark urine or jaundice and consult your doctor if you experience them. They may adjust the doses as per the observations.

Moderate

Bevacizumab (Injection Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately.

Frequently asked questions

When should I call my doctor right away?

Get medical help right away if you have signs of allergic reaction such as difficulty breathing, rash, hives, itching, and blisters. Also, let your doctor know if you experience severe headache, chest pain, severe abdominal pain, and swelling in various parts of the body.

Can Asginase 5000IU Injection damage my liver?

Asginase 5000IU Injection may affect the liver and cause serious or even life-threatening damage to the liver. Inform your doctor immediately if you notice severe stomach pain (upper right side), dark urine, clay-colored stools, tiredness, itching, or jaundice (yellowing of the skin or eyes).

I am experiencing nausea and extreme tiredness. Is this due to Asginase 5000IU Injection?

Nausea and fatigue or tiredness are some of the common side-effects of this medicine. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid food that is salty, spicy, fried, or fatty. Take plenty of rest and do light exercise daily to keep yourself active and reduce fatigue.

How to get relief from diarrhea while on treatment with Asginase 5000IU Injection?

Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), orange, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration. You can also have soups and juice frequently to hydrate yourself.

I have noticed some changes in my skin after taking Asginase 5000IU Injection. What should I do?

Use a moisturizer to get relief from rashes, dry, and itchy skin during the treatment. Avoid sun exposure. Wear SPF 30 (or higher) sunblock and protective clothing. However, if you develop yellow discoloration of your skin, inform your doctor immediately as this could be a sign of a liver problem.

Can the use of Asginase 5000IU Injection cause hyperglycemia?

Yes, Asginase 5000IU Injection can cause hyperglycemia or increase blood sugar level. Monitor your sugar level regularly and immediately inform your doctor if you see a spike in your level.

I am noticing swelling and frequent muscle cramps. Should I inform my doctor?

You might experience weakness, muscle cramps and swelling in different parts of your body. This is due to low levels of albumin, an important protein in your body. Consult your doctor who will recommend blood tests to monitor your albumin levels.

Should I avoid any food and drinks while taking Asginase 5000IU Injection?

You can continue with your normal diet unless your doctor tells you otherwise. However, it is advisable to sip water regularly to prevent you from becoming dehydrated, eating small, simple but nourishing snacks every few hours rather than large meals, and sucking on hard candy or popsicles to prevent nausea and vomiting.

What should I avoid during my treatment with Asginase 5000IU Injection?

During your treatment, it is advisable to avoid caffeine as it can make you feel dehydrated, avoid fatty fried, spicy, and overly sweet foods, as they may induce nausea, avoid alcohol and smoking. It is also advisable to avoid crowds or people with colds, as you may be at risk of infection as well as sun exposure to prevent rashes and dry skin. Do not have immunizations/vaccinations without the consent of your doctor. Use caution with sharp objects like razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised, or injured.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Other Anticancer Agents

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1720-21.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 956.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 88.
L-Asparaginase [Summary of Product Characteristics]. Dublin, Ireland: Jazz Pharmaceuticals Ireland Ltd.; 2023. [Accessed 10 Oct. 2026] (online). Available from:
Asparaginase [Summary of Product Characteristics]. Wedel, Germany: Medac; 2020. [Accessed 10 Oct. 2026] (online). Available from:
CDSCO: Manufacturing and Marketing permission issued from SND Division from 01.01.2016 to till date. [Accessed 14 Oct. 2026] (online). Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sun Pharmaceutical Industries Ltd
Address: Plot no 107/108,Namli block , Ranipool, East Sikkim 737135 || Khasra No. 1335-1340,Near EPIP- I, Vill - Bhatoli Kalan ,Baddi, Solan, Himachal Pradesh, 173205 || Acme Plaza, Andheri-Kurla Road, Andheri (East), Mumbai, Maharashtra -400059

Vendor Details

Country of origin: India

Lab tests offered by us

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Asginase 5000IU Injection

Asginase 5000IU Injection

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Asginase Injection

Benefits of Asginase Injection

Side effects of Asginase Injection

How to use Asginase Injection

How Asginase Injection works

All substitutes for Asginase 5000IU Injection

Lagicad 5000IU Injection

L Aspinase 5000IU Injection

Leucoginase 5000IU Injection

Onconase 5000IU Injection

L-Aspase 5000IU Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Imatinib mesylate (Oral Route)

Acarbose (Oral Route)

Alogliptin (Oral Route)

Bemiparin (Injection Route)

Bevacizumab (Injection Route)

Frequently asked questions

When should I call my doctor right away?

Can Asginase 5000IU Injection damage my liver?

I am experiencing nausea and extreme tiredness. Is this due to Asginase 5000IU Injection?

How to get relief from diarrhea while on treatment with Asginase 5000IU Injection?

I have noticed some changes in my skin after taking Asginase 5000IU Injection. What should I do?

Can the use of Asginase 5000IU Injection cause hyperglycemia?

I am noticing swelling and frequent muscle cramps. Should I inform my doctor?

Should I avoid any food and drinks while taking Asginase 5000IU Injection?

What should I avoid during my treatment with Asginase 5000IU Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests