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Arganat 250mg Injection

Argatroban (250mg)
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Authenticity Assured
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Arganat 250mg Injection is a medicine known as an anticoagulant or blood thinner. It helps prevent and treat blood clots. This way it reduces the risk of stroke and heart attack. It also prevents and treats clot formation in the veins of your legs, lungs, brain, and heart.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 28 Aug 2026 | 01:03 AM (IST)
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General Information

Contains

Argatroban (250mg)

Marketer

Natco Pharma Ltd

Storage

Store below 30°C
The content is shown in English
Arganat 250mg Injection image
Arganat 250mg Injection image

Product introduction

Arganat 250mg Injection is commonly used in patients with irregular heart rhythm (atrial fibrillation) to prevent clot formation. It also reduces the risk of getting clots in people who have undergone knee or hip replacement surgeries. It is given as a drip into a vein under the supervision of a doctor.

In general, you can reduce your risk of having a blood clot by making changes to your lifestyle, such as not smoking, eating a healthy diet, getting regular exercise, and losing weight if you need to.

The most common side effect of Arganat 250mg Injection is shortness of breath and a decrease in blood pressure. If you experience any symptoms, tell your doctor immediately. Other side effects include headache, diarrhea, cardiac arrest, and chest pain.

Arganat 250mg Injection needs to be treated with caution. Do not take it if you have severe kidney or liver problems, if you are currently bleeding or if you are taking other medicines to reduce blood clotting. You should not breastfeed while using this medicine. Unlike other anticoagulants, a regular blood test (PT-INR) is not required while taking this medicine.

Uses of Arganat Injection

  • Treatment and prevention of Blood clots

Benefits of Arganat Injection

Treatment and prevention of Blood clots
Arganat 250mg Injection is a type of medicine known as an anticoagulant. Although it does not “dissolve” blood clots, it can prevent them from getting bigger so your body can dissolve them over time. It will also prevent new ones from forming. It works by blocking a substance in the body which is involved in blood clotting. This keeps your blood flowing freely around your body and makes it less likely that a clot will form inside a blood vessel.

This can help prevent or reduce damage caused by stroke, clots in your lungs (pulmonary embolism) or other blood vessels (thrombosis). It can also make it less likely that parts of a clot will break off and travel to other parts of the body. It is given as an infusion (drip) into a vein under the supervision of a doctor. You should make appropriate lifestyle changes to help this medicine be effective.

Side effects of Arganat Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Arganat
  • Back pain
  • Cardiac arrest
  • Chest pain
  • Diarrhea
  • Fever
  • Headache
  • Nausea
  • Sepsis
  • Breathlessness
  • Vomiting
  • Hypotension (low blood pressure)

How to use Arganat Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Arganat Injection works

Arganat 250mg Injection is a direct thrombin inhibitor. It works by reversibly binding to thrombin, a substance in the blood that causes blood clotting. This prevents the formation of harmful clots in the body.

Quick tips

  • It is a hospital only medicine. It is given by your nurse or doctor as an infusion (drip) into a vein.
  • Notify your doctor if you see blood in your vomit, urine or stool (black, tarry stools or bright red blood).
  • Inform your doctor if you are taking other blood thinners or medicines to prevent blood clots. 

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Arganat 250mg Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Arganat 250mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CAUTION
Arganat 250mg Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Arganat 250mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

SAFE IF PRESCRIBED
Arganat 250mg Injection is safe to use in patients with kidney disease. No dose adjustment is recommended.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Arganat 250mg Injection in patients with liver disease.

Interaction with drugs

Taking Arganat with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Apixaban (Oral Route)

Do not consume Apixaban with Argatroban. If concurrent use is essential, watch out for bleeding and consult your doctor immediately.
Moderate

Rivaroxaban (Oral Route)

Do not consume Rivaroxaban with Argatroban. If concurrent use is essential, watch out for bleeding and consult your doctor immediately. They may adjust the dose of Argatroban accordingly.
Moderate

Dabigatran Etexilate (Oral Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately.
Moderate

Dasatinib (Oral Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately. Your doctor may change the treatment accordingly.
Moderate

Abciximab (Injection Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately.

Frequently asked questions

It is advised to avoid alcohol while you are taking this medicine. Alcohol may increase the effect of this medicine, causing an increase in the risk of bleeding. Regular intake of alcohol can lead to a gastric ulcer which might again cause bleeding. Do consult your doctor if any such episode of bleeding occurs.
Arganat 250mg Injection reduces your risk of developing blood clots in the blood vessels of your leg, lungs, heart and brain. You may not experience or feel any difference after taking Arganat 250mg Injection. Still, it is recommended to take this medicine as prescribed because the medicine is still working to provide its full benefits.
Arganat 250mg Injection is not advised to be taken by patients who are allergic to it. Additionally, it should not be taken if a patient is experiencing any unusual bleeding. Arganat 250mg Injection should also be avoided by patients with artificial (prosthetic) heart valves. Therefore, inform your doctor if you have ever had or plan to have a valve in your heart replaced. Also, it is advised to avoid the use Arganat 250mg Injection in patients with severe kidney disease.
Yes, Arganat 250mg Injection may increase the risk of bleeding. Be careful while doing activities that may cause an injury or bleeding. Immediately inform the doctor if you notice any abnormal bruising or bleeding.
As compared to other blood-thinning medications, Arganat 250mg Injection does not usually cause hair loss. However, there are some rare reports which suggest hair loss because of Arganat 250mg Injection. Consult your doctor if you face hair loss while taking Arganat 250mg Injection to rule out any other causes of hair loss.
Arganat 250mg Injection usually does not affect the functioning of the liver. But, long-term use of Arganat 250mg Injection may increase the chances of mild liver injury in patients with elevated liver enzymes. However, the overall chances of developing any such problems are lower than other anticoagulants. It is advised that you inform your doctor if you have a history of liver disease before starting this medicine.
Arganat 250mg Injection should be stored at room temperature between 20º and 25º C (68º-77°F) in the original packet it came in. Do not freeze. Store the medicine at a dry place and protect the medicine from moisture and light. Keep the medicine away from children.

Fact Box

Chemical Class

Dipeptides

Habit Forming

No

Therapeutic Class

CARDIAC

Action Class

Direct thrombin inhibitor- parenteral

References

  1. Weitz JI. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 860.
  2. Zehnder JI. Drugs Used in Disorders of Coagulation. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 594.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 82-83.
  4. Argatroban. North Chicago, IL: Abbott Laboratories. [Accessed 21 Jan. 2019] (online) Available from:
  5. Medicines and Healthcare Products Regulatory Agency, UK. Argotraban monohydrate. [Accessed 21 Jan. 2019] (online) Available from:
  6. Argatroban. North Chicago, Illinois: Abbott Laboratories. [Accessed 14 Mar. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Natco Pharma Ltd
Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Vendor Details

Country of origin: India

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