


Aprogen 14mg Injection
Aprotinin (14mg)
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Aprogen 14mg Injection is used to treat bleeding. It helps to prevent or reduce heavy bleeding after any surgery and in conditions such as heavy periods, dysfunctional uterine bleeding, or nosebleeds.
Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 06 May 2026 | 05:19 PM (IST)
Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 06 May 2026 | 05:19 PM (IST)
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General Information
The content is shown in English



Product introduction
Aprogen 14mg Injection must be administered under the supervision of a healthcare professional. Do not self-administer this medicine at home. You should not use it if you have any known allergies from this injection.
It may cause injection site reactions such as pain, swelling, and redness in some people. Let your doctor know if they bother you. Additionally, inform your doctor if you have undergone any cardiac surgery or you are suffering from any liver disease.
Uses of Aprogen Injection
Benefits of Aprogen Injection
Bleeding
Excessive bleeding can occur during or after major surgeries, especially heart surgeries. Aprogen 14mg Injection is used to reduce bleeding in such cases. It helps maintain blood stability by slowing down the breakdown of blood clots, reducing the need for blood transfusions, and improving surgical outcomes.
Excessive bleeding can occur during or after major surgeries, especially heart surgeries. Aprogen 14mg Injection is used to reduce bleeding in such cases. It helps maintain blood stability by slowing down the breakdown of blood clots, reducing the need for blood transfusions, and improving surgical outcomes.
Side effects of Aprogen Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Aprogen
- Injection site reactions (pain, swelling, redness)
How to use Aprogen Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Aprogen Injection works
Aprogen 14mg Injection prevents the breakdown of clots and stops bleeding.
Quick tips
- Aprogen 14mg Injection helps prevent or reduce heavy bleeding post surgery and in conditions such as heavy periods, dysfunctional uterine bleeding, and nosebleeds.
- It is given as a slow injection into a vein.
- Your doctor will prescribe the lowest effective dose for the shortest possible time necessary to relieve your symptoms.
- Your doctor may monitor your vision regularly while you are taking this medicine.
- Inform your doctor if you have a history of kidney or liver disease.
- Aprogen 14mg Injection helps prevent or reduce heavy bleeding post surgery and in conditions such as heavy periods, dysfunctional uterine bleeding, and nosebleeds.
- Your doctor will prescribe the lowest effective dose for the shortest possible time necessary to relieve your symptoms.
- If taking for heavy periods, take it on the first day as taking it before or after will not have any benefit.
- Your doctor may monitor your vision regularly while you are taking this medicine.
- Inform your doctor if you have a history of kidney or liver disease.
- Inform your doctor if there is no improvement in your bleeding after using this medicine for three consecutive periods.
Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Aprogen 14mg Injection. Please consult your doctor.

Pregnancy
CONSULT YOUR DOCTOR
The safety of Aprogen 14mg Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding
SAFE IF PRESCRIBED
Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.

Driving
NOT RELEVANT
Not relevant, as Aprogen 14mg Injection is intended for use in hospitalized patients.

Kidney
SAFE IF PRESCRIBED
Aprogen 14mg Injection is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.

Liver
CONSULT YOUR DOCTOR
There is limited data available on the use of Aprogen 14mg Injection in patients with liver disease.
Interaction with drugs
Taking Aprogen with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate
Tretinoin (Oral Route)
If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Tretinoin may increase the side effects of Aprotinin.
Mild
Ramipril (Oral Route)
Your doctor may monitor your kidney function regularly during the simultaneous use of these medicines and adjust doses accordingly if necessary.
Mild
Enalapril (Oral Route)
Your doctor may monitor your kidney function regularly during the simultaneous use of these medicines and adjust doses accordingly if necessary.
Mild
Lisinopril (Oral Route)
Your doctor may monitor your kidney function regularly during the simultaneous use of these medicines and adjust doses accordingly if necessary.
Mild
Fosinopril (Oral Route)
Your doctor may monitor your kidney function regularly during the simultaneous use of these medicines and adjust doses accordingly if necessary.
Frequently asked questions
Aprogen 14mg Injection belongs to a group of medicines called antifibrinolytics, i.e. medicines to prevent blood loss.
This injection will usually be given to you lying down by slow injection or infusion (through ‘a drip’) through a catheter into a larger vein in your body.
This injection should be avoided in children since its safety and efficacy in children below the age of 18 years have not been established. Consult your doctor for more advice.
It is advisable to avoid taking any other anti-fibrinolytic and antibiotics while taking Aprogen 14mg Injection. Inform your doctor before the start of the treatment if you are taking any of these.
Some of the serious side-effects of this medicine are blood clots in the lungs, severe blood clotting disorder that results in tissue damage and bleeding, the inability of the blood to clot or coagulate normally, chest pain, and severe allergic shock (anaphylactic shock), which is potentially life-threatening. In such cases, your doctor will stop the treatment completely.
Fact Box
Chemical Class
Peptides
Habit Forming
No
Therapeutic Class
BLOOD RELATED
Action Class
Antifibrinolytic Agents
References
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Alkem Laboratories Ltd
Address: Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Address: Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Vendor Details
Country of origin: India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)
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