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Aprotinin is used in combination with human fibrinogen, human thrombin and calcium chloride to prevent bleeding of tissues or surfaces during various surgical procedures. It may also be used in conditions where blood fails to clot properly.

How it works

Aprotinin belongs to a category of drugs called as antifibrinolytics. It acts by sealing the broken tissues and inhibiting the degradation of blood clot thereby maintaining the clot for a longer period of time.

Common side effects

Nausea, Shortness of breath, Decreased blood pressure, Itching, Hypersensitivity reaction


Expert advice

  • Before you start with aprotinin treatment you may need to take a test dose to make sure that you do not develop allergic reactions.
  • Ensure that the medication is not sprayed from a close distance to the wound and should not be injected in blood vessels.
  • You may be monitored with lab test, including kidney function test and clotting test while on aprotinin treatment.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)