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amphoDEX 50mg Injection

Amphotericin B (50mg)
Genuine
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NPPA Regulated
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Cold stored
Stored between 2-8°C
amphoDEX 50mg Injection is a medicine used to treat severe fungal infections that affect the blood, lungs, brain, or other internal organs. It is also used for a parasitic disease called visceral leishmaniasis (kala azar). It works by killing the fungus or parasite that causes the infection.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 14 Apr 2026 | 04:21 PM (IST)
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General Information

Contains

Amphotericin B (50mg)

Marketer

Samarth Life Sciences Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
amphoDEX 50mg Injection image
amphoDEX 50mg Injection image

Product introduction

amphoDEX 50mg Injection is generally given in a hospital or clinic by a doctor or nurse through a drip into the vein. It is important to complete the full course as advised, even if you start feeling better, because stopping too early can make the infection come back or become harder to treat. Drink plenty of fluids and rest well to help you get the best results from the treatment.


Common side effects of amphoDEX 50mg Injection include fever, chills, headache, nausea, or tiredness after the injection, especially with the first few doses. These usually get better as your body adjusts. You may also notice kidney-related problems, so your doctor will check your blood and urine often. If you experience any symptoms that persist or worsen, inform your doctor.


amphoDEX 50mg Injection should be taken only under strict medical guidance. People with kidney disease, heart problems, or electrolyte imbalances need extra care, as the medicine can make these conditions worse. It is important not to take any other medicines, especially painkillers or antibiotics, without your doctor’s approval because they may increase side effects. Pregnant or breastfeeding women should use it only if clearly needed and advised by the doctor.

Uses of amphoDEX Injection

Benefits of amphoDEX Injection

Treatment of Severe fungal infections
amphoDEX 50mg Injection is a strong medicine used when fungal infections become very serious and spread inside the body. It works by damaging the wall of the fungus, thereby killing it. Even though it can sometimes cause side effects, it is often the most reliable treatment for dangerous infections like those affecting the lungs, blood, or brain.
Kala-azar
Kala azar is a disease caused by leishmania parasites mainly by the bite of infected sandflies. amphoDEX 50mg Injection helps to kill the infection causing parasites and helps to treat the infection. This medicine is given by a doctor or nurse and should not be self-administered. It usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all the parasites are killed and do not become resistant.
Treatment of Leishmaniasis.
Visceral leishmaniasis, also known as kala azar, is a serious infection caused by parasites that affect internal organs like the liver, spleen, and bone marrow. amphoDEX 50mg Injection helps is especially helpful when other medicines do not work or the disease comes back. It kills the parasite by damaging its protective covering, which helps patients recover faster and improves their chances of a complete recovery.

Side effects of amphoDEX Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of amphoDEX
  • Nausea
  • Vomiting
  • Chills
  • Headache
  • Anemia (low number of red blood cells)
  • Abnormal liver function tests
  • Decreased magnesium level in blood
  • Diarrhea
  • Decreased appetite
  • Hypotension (low blood pressure)
  • Skin rash
  • Nephrocalcinosis
  • Increased creatinine level in blood
  • Abnormal renal function tests
  • Renal tubular acidosis
  • Injection site reactions (pain, swelling, redness)
  • Increased potassium level in blood

How to use amphoDEX Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How amphoDEX Injection works

amphoDEX 50mg Injection works by binding to ergosterol, an essential component of fungal and parasite cell membranes. This binding creates pores in the membrane, causing leakage of vital cell contents and ultimately leading to cell death. This action makes it highly effective against a wide range of fungi and the parasite that causes kala azar.

Quick tips

  • amphoDEX 50mg Injection should always be taken in a hospital or clinic under medical supervision.
  • Do not skip or stop doses even if you start feeling better, as the infection may come back.
  • Drink plenty of fluids unless your doctor advises otherwise, to help protect your kidneys.
  • Report symptoms like difficulty breathing, chest pain, or reduced urine output immediately.
  • Do not take any other medicines, including herbal supplements, without consulting your doctor.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with amphoDEX 50mg Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of amphoDEX 50mg Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
amphoDEX 50mg Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

CAUTION
amphoDEX 50mg Injection may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of amphoDEX 50mg Injection in patients with kidney disease. Please consult your doctor.
Liver

Liver

SAFE IF PRESCRIBED
amphoDEX 50mg Injection is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking amphoDEX with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Tenofovir disoproxil fumarate (Oral Route)

Do not consume Tenofovir disoproxil fumarate with Amphotericin B. If concurrent use is essential, your doctor may monitor your kidney function closely.
Severe

Vancomycin (Injection Route)

If concurrent use is essential, your doctor may closely monitor your kidney's functioning and overall treatment.
Severe

Zidovudine (Oral Route)

Your doctor may monitor your blood cell count for toxicity of medicines and adjust the doses as per the observations.
Severe

Amikacin (Injection Route)

Your doctor may monitor your kidney function regularly.
Severe

Cisplatin (Injection Route)

If concurrent use is essential, your doctor may closely monitor your kidney's functioning and overall treatment.

Frequently asked questions

amphoDEX 50mg Injection is used to treat very serious fungal infections in the blood, lungs, brain, or other organs, and also for a parasitic disease called visceral leishmaniasis (kala azar).
amphoDEX 50mg Injection is given by a doctor or nurse as a drip into the vein in a hospital or clinic. You should not self-administer this medicine on your own.
Because amphoDEX 50mg Injection can cause side effects, your doctor will monitor you closely with regular check-ups and blood tests to make sure the treatment is safe and effective.
The duration depends on the type and severity of your infection. Your doctor will decide how many doses you need. It is important not to miss or stop treatment early.
Always inform your doctor about all medicines or supplements you are taking. Some drugs can interact and increase the risk of side effects.

Fact Box

Chemical Class

Aminoglycosides

Habit Forming

No

Therapeutic Class

ANTI INFECTIVES

Action Class

Polyene Antifungals

References

  1. Central Drugs Standard Control Organisation (CDSCO). [Accessed 29 Mar. 2019] (online) Available from:
  2. Phillips MA, Stanley SL Jr. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1424.
  3. Bennett JE. Antifungal Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1571-75.
  4. Sheppard D, Lampiris HW. Antifungal Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 836-38.
  5. Amphotericin B [Drug Label]. San Dimas, California: Gilead Sciences, Inc.; 2000. [Accessed 20 Sept. 2025] (online) Available from:
  6. Amphotericin B [Prescribing Information]. Big Flats, NY: XGen Pharmaceuticals DJB, Inc.; 2022. [Accessed 20 Sept. 2025] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Samarth Life Sciences Pvt Ltd
Address: Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver amphoDEX 50mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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