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Amitone Syrup

Prescription Required

Overview

Introduction

Amitone Syrup is used in the treatment of depression. It is also used to treat and prevent chronic nerve-related (neuropathic) pain, migraine, tension-type headache and nighttime bedwetting (nocturnal enuresis) by older children (6 years and above) at different doses.

Amitone Syrup is known as a tricyclic antidepressant. It is normally taken before bedtime because it can make you feel sleepy. It can be taken with or without food. The dose and how often you need to take it will be decided by your doctor so that you get the right amount to control your symptoms. It may be increased gradually. This medicine may not work straight away and it could be several weeks before you get the full effects.

How long you need to use it depends on what you are taking it for, but it is important to continue taking this medication even if you feel well. Do not suddenly stop taking it without consulting your doctor as it may make your condition worse. Your dose will need to be gradually decreased when the doctor decides to stop it.

The most common side effects of this medicine include increased heart rate, constipation, dizziness, feeling thirsty or tired, dry mouth and difficulty urinating. It may also make you aggressive or confused and can lead to weight gain in some people. Most of the common side effects tend to be mild. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects are rare. This medicine is not addictive, but you can get extra side effects (withdrawal symptoms) if you stop taking it suddenly.

Side effects of Amitone Syrup

Common
  • Constipation
  • Difficulty in urination
  • Dryness in mouth
  • Increased heart rate
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Weight gain
  • Aggressive behavior
  • Agitation
  • Nasal congestion (stuffy nose)

How to use Amitone Syrup

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Amitone Syrup may be taken with or without food, but it is better to take it at a fixed time.

How Amitone Syrup works

Amitone Syrup is a tricyclic antidepressant. It works by increasing the levels of chemical messengers in the brain that help in regulating mood and treat depression. It also stops the movement of pain signals from nerves to the brain thereby relieving neuropathic pain (pain from damaged nerves).

Safety Advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Amitone Syrup.
Pregnancy
CONSULT YOUR DOCTOR
Amitone Syrup may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Amitone Syrup is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Amitone Syrup may cause side effects which could affect your ability to drive.
Amitone Syrup may impair your alertness which may affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Amitone Syrup is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Amitone Syrup may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Amitone Syrup should be used with caution in patients with liver disease. Dose adjustment of Amitone Syrup may be needed. Please consult your doctor.
Use of Amitone Syrup is not recommended in patients with severe liver disease.

What if you forget to take Amitone Syrup?

If you miss a dose of Amitone Syrup, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
No alternate brands found for this medicine

Quick Tips

  • It may take 4 to 6 weeks for Amitone Syrup to start working. Keep taking it as prescribed.
  • It may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
  • Avoid consuming alcohol when taking Amitone Syrup as it may cause excessive sleepiness.
  • Monitor your weight during the treatment as this medicine can cause weight gain and increased appetite.
  • It may cause sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
  • Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.

Interaction with Drugs

Taking Amitone with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Lizolan, Lidoford, Mapzolide
LIFE-THREATENING
Brand(s): Trima, Rimarex, Morex
LIFE-THREATENING
Brand(s): Moxicheck, Moxonex, Unsym
LIFE-THREATENING

Patient Concerns

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heat from head, and also pain,please tell medicine
Dr. Vikas Sharma
Neurology
amitone 10 mg hs
Am feeling like something in head I mean am not comfortable doctor There is no pain but feeling like heavy
Dr. Vikas Sharma
Neurology
Tab amitone 10 mg daily nite
arrow
Do you have any questions related to Amitone Syrup ?

User Feedback


FAQs

Q. What other lifestyle changes should I make to get maximum benefit of Amitone?

Antidepressants, including Amitone, are just one of several approaches to treat depression. Certain lifestyle changes can help you get maximum benefit of Amitone and help you recover fast. Keeping active and eating a healthy diet can make a significant difference to how quickly you recover from depression. Think positively and try to discuss your thoughts with others to reduce stress. Practice yoga or take up a hobby. Ensure that you have a sound sleep to calm your mind. Stay away from smoking or alcohol consumption as these will only worsen your depression. Take your medicines as prescribed even if you start feeling better.

Q. Is there anything I need to be careful about while on therapy with Amitone?

Amitone may cause drowsiness and dizziness, especially in the beginning of the treatment. So, avoid driving or using machinery until you know how the medicine affects you. Also, it is not advisable to drink alcohol during treatment with this medicine as it might increase sleepiness.

Q. Can the use of Amitone affect my sex life?

Yes, Amitone can affect sex life in both men and women. It may cause decreased sexual desire or you may experience discomfort during intercourse. Men may experience inability to develop or maintain an erection during sexual activity and may be unable to have an orgasm. If you notice these symptoms, do not stop taking the medicine but consult your doctor.

Q. I have been taking Amitone for depression since a week and recently I have been wanting to harm myself. What should I do? Is it because of the medicine?

You should immediately consult your doctor or go to the hospital. Your suicidal tendencies may have increased because of your disease or the medicine. Generally, Amitone takes about 2 weeks to show its effect but may take longer. Therefore, when you start taking Amitone, you may have thoughts about killing or harming yourself. This is more common in people who previously had suicidal tendencies or are young adults (less than 25 years old). However, the effect of medicine is different for every individual.

Q. Can Amitone cause urinary problems?

Yes, Amitone can cause urinary problems. It is more commonly seen in elderly patients who are more than 65 years old. The patient may face difficulty in passing urine which can further lead to a urinary tract infection. Consult your doctor immediately if you develop these symptoms.

Q. If my pain is not relieved, can I take more than the recommended dose?

No, you should use Amitone strictly as prescribed by the doctor. If the dose exceeds, you may develop drowsiness, confusion, difficulty in speech, dry mouth, tiredness, difficulty in walking, fever, difficulty in breathing, blue discoloration of the skin and decreased heartbeat. Your pain may not be relieved because Amitone takes about 2 weeks to show its effect, but it may take longer in some cases. The duration of treatment can differ from individual to individual. Consult your doctor if your symptoms are not relieved.

Q. Does Amitone cause any effect on pregnancy or the newborn?

Do not take Amitone during pregnancy unless recommended by the doctor. If you take this medicine during the last trimester of the pregnancy, the newborn may develop symptoms such as irritability, rigidity, irregular body movements, irregular breathing, poor drinking, loud crying, difficulty in urinating and constipation.

Q. I have been prescribed Amitone for pain. When will I start feeling better?

You may start feeling better after 2 weeks of starting Amitone. However, it may take 4-6 weeks to see the full benefits of the medicine.

Q. Can I stop taking Amitone when my pain is relieved?

No, do not stop taking Amitone even if the pain is relieved. You should use Amitone as advised by the doctor. Stopping the medicine suddenly may cause unpleasant symptoms like headache, feeling unwell, sleeplessness and irritability. Consult your doctor for the duration of the treatment since the dose of Amitone needs to be reduced gradually.

Q. How long does Amitone take to work?

You may see an improvement in your symptoms after a couple of weeks, although it usually takes between 4 and 6 weeks before you feel the benefits. Do not stop taking Amitone after 1 or 2 weeks just because you feel it is not helping your symptoms. Give the medicine at least 6 weeks to work.

Q. How will Amitone make me feel?

Antidepressants like Amitone help to gradually lift your mood. You may notice that you sleep better and are less anxious. You may worry less about little things that used to bother you. Amitone will not make you feel excessively or unusually happy. It will help you feel like yourself again.

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References
  1. Stahl SM, editor. Amitriptyline. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 25-30.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 58-59.
  3. Amitriptyline. Princeton: Sandoz Inc; 2014. [Accessed on 19 Mar. 2019] (online) Available from:External Link
  4. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Amitriptyline. [Updated 2018 Oct 31]. [Accessed 19 Feb. 2020] (online) Available from:External Link
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:External Link
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