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Alphagan Eye Drop
Brimonidine (0.2% w/v)
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Alphagan Eye Drop is used in the treatment of ocular hypertension (pressure in the eye) and glaucoma. It helps lower high pressure in the eye and reduces the risk of vision loss. This medicine may be used alone or in combination with another eye drop that reduces pressure in the eye.
Written By Dr. Mayank, Pharm.D,
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology,
Last updated on 22 Sep 2025 | 06:02 PM (IST)
Written By Dr. Mayank, Pharm.D,
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology,
Last updated on 22 Sep 2025 | 06:02 PM (IST)
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5 ml Eye Drop
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General Information
The content is shown in English





Product introduction
Alphagan Eye Drop is for external use only. Use it in the dose and duration as advised by the doctor. If you wear contact lenses, remove them before using the medication. Avoid touching the tip of the dropper to any surface, as it may contaminate the eye drop. For best results, use it daily in the evening or at night.
The common side effects include allergic conjunctivitis, burning sensation, conjunctival inflammation, conjunctival hyperemia, eye itching, allergic reaction in the eyes, dry mouth, and visual disturbance. If they persist or worsen, inform your doctor. Caution is advised for driving after administration of this injection if your eyes are unable to concentrate and react.
Uses of Alphagan Eye Drop
- Glaucoma
- Ocular hypertension
Benefits of Alphagan Eye Drop
Glaucoma
Glaucoma is a group of eye conditions that damage the optic nerve, the health of which is vital for good vision. This damage is often caused by an abnormally high pressure in your eye. Glaucoma is one of the leading causes of blindness for people over the age of 60 or older. Alphagan Eye Drop is used to reduce swelling and pressure inside the eye. This helps to prevent complications of glaucoma such as blindness and improves the vision.
Glaucoma is a group of eye conditions that damage the optic nerve, the health of which is vital for good vision. This damage is often caused by an abnormally high pressure in your eye. Glaucoma is one of the leading causes of blindness for people over the age of 60 or older. Alphagan Eye Drop is used to reduce swelling and pressure inside the eye. This helps to prevent complications of glaucoma such as blindness and improves the vision.
Ocular hypertension
Ocular hypertension is a condition where the pressure inside the eye is higher than normal eye pressure. This may occur due to an injury, certain diseases or as an adverse effect of certain medications. Alphagan Eye Drop reduces the fluid accumulation of the eye and facilitates draining of the fluid from the eyes. This helps treat ocular hypertension and prevents further damage or complications such as vision changes or even vision loss.
Ocular hypertension is a condition where the pressure inside the eye is higher than normal eye pressure. This may occur due to an injury, certain diseases or as an adverse effect of certain medications. Alphagan Eye Drop reduces the fluid accumulation of the eye and facilitates draining of the fluid from the eyes. This helps treat ocular hypertension and prevents further damage or complications such as vision changes or even vision loss.
Side effects of Alphagan Eye Drop
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Alphagan
- Eye itching
- Allergic reaction in eye
- Conjunctival hyperemia
- Follicular conjunctivitis
- Dryness in mouth
- Allergic conjunctivitis
- Burning sensation
- High blood pressure
- Visual disorder
How to use Alphagan Eye Drop
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off the extra liquid.
How Alphagan Eye Drop works
Alphagan Eye Drop is a sympathomimetic. It works by decreasing the production of aqueous humor (fluid in the eye), thereby lowering the increased eye pressure.
All substitutes for Alphagan Eye Drop
For information purposes only. Consult a doctor before taking any medicine.
Quick tips
- For best results, put one drop 2-3 times daily in the affected eye(s).
- Apply pressure on the corner of the eye (close to the nose) for about 1 minute, immediately after instilling the drop.
- Remove contact lenses before using Alphagan Eye Drop and allow at least 15 minutes before reinserting them.
- Do not touch the tip of the dropper to any surface or to your eye to avoid contaminating the eye drops.
- Wait for at least 5-10 minutes before delivering the next medication in the same eye to avoid dilution.
- Alphagan Eye Drop may cause short-term blurring of vision when first used. Use caution before driving or using machines.
- It may cause a temporary burning or itching sensation in the eye. Inform your doctor if this does not go away.
- Make sure to use it within 4 weeks of opening the bottle.
Safety advice

Alcohol
No interaction found/established

Pregnancy
CONSULT YOUR DOCTOR
Alphagan Eye Drop may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Alphagan Eye Drop during breastfeeding is not available. Please consult your doctor.

Driving
UNSAFE
Alphagan Eye Drop may cause side effects which could affect your ability to drive.
Alphagan Eye Drop may cause blurred or abnormal vision. This effect may seem worse at night or in reduced lighting and this may affect the ability to drive.
Alphagan Eye Drop may cause blurred or abnormal vision. This effect may seem worse at night or in reduced lighting and this may affect the ability to drive.

Kidney
No interaction found/established

Liver
No interaction found/established
Interaction with drugs
Taking Alphagan with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate
Amitriptyline (Oral Route)
Do not consume Brimonidine with Amitriptyline. If concurrent use is essential, please consult your doctor. Amitriptyline may reduce the efficacy of Brimonidine.
Moderate
Clomipramine (Oral Route)
Do not consume Brimonidine with Clomipramine. If concurrent use is essential, please consult your doctor. Clomipramine may reduce the efficacy of Brimonidine.
Moderate
Imipramine (Oral Route)
Do not consume Brimonidine with Imipramine. If concurrent use is essential, please consult your doctor. Imipramine may reduce the efficacy of Brimonidine.
Moderate
Nortriptyline (Oral Route)
Do not consume Brimonidine with Nortriptyline. If concurrent use is essential, please consult your doctor. Nortriptyline may reduce the efficacy of Brimonidine.
Moderate
Tranylcypromine (Oral Route)
Do not consume Brimonidine with Tranylcypromine. If concurrent use is essential, watch out for breathlessness, fatigue, drowsiness, sedation, faintness or vomiting and consult your doctor if you experience it. Tranylcypromine may decrease the metabolism of Brimonidine.
Frequently asked questions
No, Alphagan Eye Drop is not a beta blocker. It is an alpha-adrenergic agonist, which means it acts on alpha-adrenergic receptors present in the eye. This medicine reduces the high pressure in the eye by decreasing the amount of fluid in the eyes. It has a minimal effect on the heart and lungs.
Yes, Alphagan Eye Drop may cause drowsiness and may also cause fatigue, which may impair the ability to drive or use machinery. It may also cause blurred or abnormal vision, which could cause difficulty in driving or using machinery, especially at night or in reduced lighting. You should avoid driving or using machinery until these symptoms have subsided.
Alphagan Eye Drop may cause low or high blood pressure. Before taking Alphagan Eye Drop, inform your doctor if you are already taking any medicines to lower blood pressure. Moreover, keep a regular check on your blood pressure while you are taking Alphagan Eye Drop.
No, Alphagan Eye Drop does not cause pupil dilation. On the contrary, in very rare cases, it may cause pupil constriction, also called miosis. If you experience miosis, you may have night vision difficulty, halos, and glare. Contact your doctor if you experience these symptoms.
Fact Box
Chemical Class
Quinoxaline Derivative
Habit Forming
No
Therapeutic Class
OPHTHAL
Action Class
Ocular Sympathomimetics
References
- Westfall TC, WestfallIn DP. Adrenergic Agonists and Antagonists. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 297.
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 04 Apr. 2019] (online) Available from:
- Brimonidine tartrate ophthalmic solution [Prescribing Information]. Bridgewater, NJ: Bausch & Lomb Americas Inc.; 2022. [Accessed 24 Mar. 2025] (online) Available from:
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User feedback
Thrice A Day
100%
Glaucoma
86%
Others
14%
Average
78%
Excellent
22%
No Side Effect
33%
Dryness in mouth
33%
Blurred vision
33%
With or without food
50%
With food
50%
Expensive
83%
Average
17%
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Disclaimer
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Allergan India Pvt Ltd
Address: No.3, Kasturba Road, Level 2, Prestige Obelisk, Bangalore – 560 001., KARNATAKA, INDIA
Address: No.3, Kasturba Road, Level 2, Prestige Obelisk, Bangalore – 560 001., KARNATAKA, INDIA
Vendor Details
Country of origin: India
A licensed vendor partner from your nearest location will deliver Alphagan Eye Drop. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
A licensed vendor partner from your nearest location will deliver Alphagan Eye Drop. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)
Why we need a prescription?
Provide right medicines
Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose
In accordance with the law
Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945














