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Imipramine is used in the treatment of depression and bed-wetting.

How it works

Imipramine increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

Common side effects

Sleepiness, Blurred vision, Constipation, Weight gain, Dry mouth, Difficulty in urination, Increased heart rate, Orthostatic hypotension (sudden lowering of blood pressure on standing)

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Expert advice

  • It can take 4 to 6 weeks for Imipramine to start working.
  • You should continue the treatment for at least 6 months after you feel better to stop depression from coming back.
  • If your doctor asks you to stop Imipramine, you should reduce the dose slowly over 4 weeks.
  • Avoid consuming alcohol when taking the Imipramine, as it may cause excessive drowsiness and calmness.
  • The addiction/dependence potential of Imipramine is very less.
  • It may be extremely dangerous in overdose.

Frequently asked questions


Q. Is imipramine a monoamine oxidase inhibitor/ anticholinergic/ tricyclic antidepressant/benzodiazepine?
Imipramine belongs to a class of medication called tricyclic antidepressants. It is not a monoamine oxidase inhibitor/ anticholinergic/ benzodiazepine
Q. Is imipramine addictive?
No, imipramine is not addictive
Q. Is imipramine sedative?
It had sedative effect, due to its antihistaminergic effect
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Q. Is imipramine good for anxiety?
Yes, imipramine may be used for the treatment of anxiety (panic disorder).

Content on this page was last updated on 19 May, 2017, by Dr. Varun Gupta (MD Pharmacology)