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Imipramine is used to treat depression and night time bed wetting in children.

How it works

Imipramine belongs to a class of medications called tricyclic antidepressants. Imipramine acts by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance. It also decreases one of the stages of sleep where wetting occurs. 

Common side effects

Frequent urge to urinate, Acne-like rash, Altered libido, Change in appetite, Change in body weight, Constipation, Drowsiness, Dry mouth, Difficulty in urination, Excitement, Altered heart rate, Increased sweating, Muscle cramp, Slow speech, Walking difficulties, Weakness, Yellow discoloration of skin, Yellow discoloration of eye, Nightmare


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Expert advice

  • Doctor’s advice should be considered in case of patients with following history of disease conditions:  heart disease such as irregular heartbeats, heart block or have recently had heart attack diabetes, high blood pressure, heart failure or have had a heart attack, or condition that affects your adrenal glands; periods of increased and exaggerated behavior (mania); severe liver disease, or suffering with porphyria (a genetic disorder of the red blood cells hemoglobin causing skin blisters, abdominal pain and brain/nervous system disorders).
  • Take special precautions and consult your doctor while taking imipramine if you are not able to pass urine, or have increased pressure in the eye (glaucoma).

Frequently asked questions


Q. Is imipramine a monoamine oxidase inhibitor/ anticholinergic/ tricyclic antidepressant/benzodiazepine?
Imipramine belongs to a class of medication called tricyclic antidepressants. It is not a monoamine oxidase inhibitor/ anticholinergic/ benzodiazepine.
Q. Is imipramine addictive?
No, imipramine is not addictive.
Q. Is imipramine sedative?
It had sedative effect, due to its antihistaminergic effect.
Q. Is imipramine good for anxiety?
Yes, imipramine may be used for the treatment of anxiety (panic disorder).

Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)