Advamab 400 Injection

Bevacizumab (400mg)

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Prescription

required

Cold stored

Stored between 2-8°C

Advamab 400 Injection is an anticancer medication. It is used in the treatment of cancer of colon and rectum, non-small cell lung cancer, kidney cancer, brain tumor, ovarian and cervical cancer. It helps to prevent the growth of new blood vessels that feed tumors and stops tumors from growing.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 06 Apr 2026 | 04:05 PM (IST)

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General Information

Contains

Bevacizumab (400mg)

Marketer

Alkem Laboratories Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Advamab 400 Injection is an effective medicine, first-line option when used together with other cancer medicines. It is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. The doctor will decide your dose and duration and will check you for signs of an infusion reaction such as high blood pressure and trouble breathing. You keep taking Advamab 400 Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking it or not. You may be advised to check blood pressure and levels of protein in urine while you are taking this medication.

The most common side effects of this medicine include nosebleeds, headache, high blood pressure, rhinitis, protein in urine, change in taste, dry skin, bleeding, lacrimation disorder, back pain, and exfoliative dermatitis. Inform your doctor that you are taking this medication before undergoing any surgical procedure, as the drug has ability to lower the ability of wound healing. Other than this, it also enhances your risk of bleeding thus if you notice any unusual bleeding or bleeding consult with your doctor immediately.

Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.

Uses of Advamab Injection

Benefits of Advamab Injection

Cancer of colon and rectum
Cancer of the colon and rectum affects the large intestine (colon) or its end portion (rectum) and usually begins as small, noncancerous polyps. Over time, these may become cancerous, leading to symptoms like blood in stool, changes in bowel habits, and weight loss. If not diagnosed early, the cancer can spread to other organs such as the liver or lungs. Advamab 400 Injection helps by blocking the growth of new blood vessels that feed the tumor, thereby slowing its growth. This improves the effectiveness of other cancer treatments and may extend survival in patients with advanced colorectal cancer.

Ovarian cancer
Ovarian cancer originates in the ovaries and is often called a “silent killer” because it typically causes vague or no symptoms in the early stages. Advamab 400 Injection aids in controlling tumor progression by cutting off its blood supply. This can delay the worsening of the disease, enhance the response to chemotherapy, and improve overall treatment outcomes.

Cervical cancer
Cervical cancer begins in the cervix, the lower part of the uterus that connects to the vagina. It is mainly caused by persistent infection with high-risk human papillomavirus (HPV) types. Symptoms can include abnormal vaginal bleeding, pain during intercourse, and pelvic pain. In advanced stages, the cancer may spread to surrounding organs. Advamab 400 Injection helps manage the disease by preventing the formation of new blood vessels around the tumor, which slows down cancer progression and enhances the effects of other treatments.

Kidney cancer
Kidney cancer, particularly renal cell carcinoma, often develops without early symptoms and may be discovered incidentally during imaging tests. As it grows, it can cause blood in urine, back pain, or a mass in the abdomen. If not treated promptly, it may spread to the lungs, bones, or liver. Advamab 400 Injection works by reducing the blood supply to the tumor, slowing its growth. This provides better disease control and helps improve the results of other cancer therapies.

Brain tumor
Brain tumors are abnormal growths within the brain that can be either benign or malignant. Malignant brain tumors can cause headaches, seizures, vision problems, and cognitive changes depending on their location and size. Because they grow in a confined space, they can increase pressure within the skull, making them especially dangerous. Advamab 400 Injection helps reduce tumor size and brain swelling by cutting off the tumor's blood supply. This can relieve symptoms, reduce the need for steroids, and improve quality of life during treatment.

Non-small cell lung cancer
Non-small cell lung cancer is the most common type of lung cancer. It tends to grow and spread more slowly than small-cell lung cancer but is often diagnosed at a later stage. Symptoms may include persistent cough, chest pain, breathlessness, and unexplained weight loss. Advamab 400 Injection helps by stopping the growth of blood vessels that supply nutrients to the tumor, making it harder for the cancer to grow or spread. This improves the impact of chemotherapy and may increase survival chances and symptom control.

Side effects of Advamab Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Advamab

Nosebleeds
Headache
High blood pressure
Inflammation of the nose
Protein in urine
Taste change
Dry skin
Hemorrhage
Increased lacrimation
Back pain
Exfoliative dermatitis

How to use Advamab Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Advamab Injection works

Advamab 400 Injection is a anti-angiogenic medication. It works by blocking a protein called vascular endothelial growth factor (VEGF). This stops the formation of blood vessels that bring oxygen and nutrients to cancerous cells.

All substitutes for Advamab 400 Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Advamab 400 Injection is an effective, first-line option when used together with other medicines for certain types of cancers such as colorectal, lung, cervical, and kidney cancers.
Advamab 400 Injection is given as an infusion. Your doctor or nurse will monitor you for signs of an infusion reaction such as high blood pressure and trouble breathing.
It can lower your wound healing ability. Inform your doctor that you are taking this medication before undergoing any surgical procedure.
It can increase the risk of bleeding. Inform your doctor if you notice any unusual bleeding or bleeding that doesn't stop easily.
Your doctor may regularly check your blood pressure and levels of protein in your urine while you are on Advamab 400 Injection.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Advamab 400 Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Advamab 400 Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Advamab 400 Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Advamab 400 Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Sleepiness and fainting have been reported with Advamab 400 Injection and this may impair your ability to drive.

Kidney

CAUTION

Advamab 400 Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Advamab 400 Injection in patients with liver disease.

Interaction with drugs

Taking Advamab with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Panitumumab (Injection Route)

Do not consume Panitumumab with Bevacizumab during the treatment of metastatic colon cancer.

Severe

Yellow fever virus (live, attenuated) (Injection Route)

Concomitant use is not recommended.

Moderate

Etoricoxib (Oral Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately.

Moderate

Ticagrelor (Oral Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately.

Moderate

Diclofenac (Oral Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately.

Frequently asked questions

What kinds of cancer can Advamab 400 Injection be used for ?

Advamab 400 Injection is approved for the treatment of cancer of the colon or rectum that has spread to other parts of the body. It must be given along with chemotherapy. Other types of cancers that it helps with includes certain types of lung cancer, kidney cancer, ovarian cancer, cervical cancer, and glioblastoma (a type of brain tumor).

How is Advamab 400 Injection given?

Advamab 400 Injection is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. Your doctor will decide your dose and duration and will monitor you for signs of an infusion reaction.

How long can I take Advamab 400 Injection for?

You keep taking Advamab 400 Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking Advamab 400 Injection. If your cancer progresses during this initial treatment, talk to your doctor if a different chemotherapy may be an option.

How Advamab 400 Injection works differently from chemotherapy?

Chemotherapy attacks fast-growing cells, like cancer cells. In contrast, the purpose of Advamab 400 Injection is to prevent the growth of new blood vessels that feed tumors. This causes the tumour to shrink, or to stop growing.

Does a person taking Advamab 400 Injection still need chemotherapy?

Chemotherapy is still needed along with taking Advamab 400 Injection. It makes chemotherapy work better.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Vascular Endothelial Growth Factor (VEGF) Inhibitors

Related lab tests

Carcino Embryonic Antigen

Complete Blood Count

Human Papilloma Virus

Papanicolaou (PAP) Cytology

References

Avastin (Bevacizumab) [Product Information]. [Accessed 07 Oct. 2024] (online) Available from:
Avastin (Bevacizumab) [Prescribing Information]. South San Francisco, CA: Genentech, Inc.; 2022. [Accessed 07 Oct. 2024] (online) Available from:
Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1739-40.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 142-43.
Bevacizumab. South San Francisco, California: Genentech, Inc.; 2004 [revised Sep. 2011]. [Accessed 26 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Bevacizumab. [Updated 2019 Jul 20]. [Accessed 18 Feb. 2020] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Alkem Laboratories Ltd
Address: Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Advamab 400 Injection

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Advamab Injection

Benefits of Advamab Injection

Side effects of Advamab Injection

How to use Advamab Injection

How Advamab Injection works

All substitutes for Advamab 400 Injection

Krabeva 400mg Injection

Bevacirel 400mg Injection

Avangio Injection

Avastimab 400mg Injection

Bevnexxa 400mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Panitumumab (Injection Route)

Yellow fever virus (live, attenuated) (Injection Route)

Etoricoxib (Oral Route)

Ticagrelor (Oral Route)

Diclofenac (Oral Route)

Frequently asked questions

What kinds of cancer can Advamab 400 Injection be used for ?

How is Advamab 400 Injection given?

How long can I take Advamab 400 Injection for?

How Advamab 400 Injection works differently from chemotherapy?

Does a person taking Advamab 400 Injection still need chemotherapy?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Carcino Embryonic Antigen

Complete Blood Count

Human Papilloma Virus

Papanicolaou (PAP) Cytology

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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