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Adcapone Tablet



Adcapone Tablet is a prescription medicine used in the treatment of Parkinson's disease. This medicine helps to treat excessive shaking by slowing down the body movements. It works by increasing the amount of dopamine, a chemical messenger that is needed to control the abnormal movements.

Adcapone Tablet has no antiparkinsonian effect on its own. It is used in combination with carbidopa/levodopa. It helps to treat wearing-off symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. It may be taken with or without food, preferably at bedtime. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor.

If you have missed a dose, take it as soon as you remember it. It is important that this medication is not stopped suddenly without talking to the doctor as it may worsen your condition. Your doctor may advise for periodic skin examination as it can cause melanoma.

Some common side effects of this medicine include nausea, vomiting, fatigue, confusion, constipation, insomnia(difficulty sleeping), nightmares, and increased sweating. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. It is common to have diarrhea with this medicine, so drink plenty of fluids and watch for weight loss. Inform your doctor if you develop any unusual changes in mood, an abnormally high sex drive, and hallucinations. It may cause your urine to change in a brownish-orange color but it is not harmful and usually resolves once treatment is completed. Please consult your doctor if these side effects worry you or do not go away.

Uses of Adcapone Tablet

Side effects of Adcapone Tablet

  • Nausea
  • Vomiting
  • Fatigue
  • Confusion
  • Constipation
  • Insomnia (difficulty in sleeping)
  • Nightmare
  • Hallucination
  • Increased sweating
  • Fall
  • Urine discoloration
  • Dizziness
  • Diarrhea
  • Muscle coordination impaired
  • Ischemic heart disease
  • Heart attack
  • Abdominal pain
  • Dryness in mouth

How to use Adcapone Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Adcapone Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Adcapone Tablet works

Adcapone Tablet is a selective reversible inhibitor which is given in combination with levodopa. It works by inhibiting a chemical messenger [catechol-O-methyl transferase (COMT)] which in turn helps in increasing the amount of dopamine (chemical messenger) in the brain. Thus, an adequate amount of dopamine in the brain helps to coordinate body movements. This is how it works to control symptoms of Parkinson's disease.

Safety Advice

Adcapone Tablet may cause excessive drowsiness with alcohol.
Adcapone Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Adcapone Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Adcapone Tablet may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
Adcapone Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Adcapone Tablet may not be needed in these patients. Please consult your doctor.
Adcapone Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

What if you forget to take Adcapone Tablet?

If you miss a dose of Adcapone Tablet, skip it and continue with your normal schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Adcapone Tablet
Entacom Tablet
Intas Pharmaceuticals Ltd
save 28%

Quick Tips

  • You have been prescribed Adcapone Tablet to enhance the effectiveness of levodopa for treatment of Parkinson's disease.
  • It can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Inform your doctor if you develop impulsive, unusual behavior and/or an abnormally high sex drive.
  • Talk to your doctor in case you develop hallucinations or other changes in your behavior.
  • It is common to have diarrhea with this drug. Therefore, drink plenty of fluids and watch for weight loss.
  • Do not get worried if you notice a reddish-brown discoloration in your urine as it is harmless in nature.
  • Do not stop taking the medication suddenly without talking to your doctor.

Patient Concerns

Parkinson's disease tremors ,Insomnia.
Dr. Ravi Shankar M.
Use Dhanadanayanadi kashayam 15ml twice a day with 15 ml water before food and Zandopa 10 grams twice a day witk milk after food and Tab Dhanvantari Vati 1-0-1 after food for 2 months
My mother suffering from Parkinson disease from 7 year , any affective medicine ?? Both hand and leg is shaking ,hardly stand up from bed himself, using parking tablet, syndopa plus and parkitidin
Dr. Saurav Arora
Dear sir Parkinson's can only be managed with Homeopathy. There are few medicines which are used to improve quality of life and decrease disease progression
Do you have any questions related to Adcapone Tablet ?

User Feedback


Q. Can Adcapone be crushed or split? If not, then how it should be taken?

No, Adcapone should not be crushed or split. Take it as a whole with a full glass of water at the same time as you take a dose of levodopa

Q. Does Adcapone have any effect on urine color?

Yes, Adcapone may cause your urine to change to a brownish-orange color. This effect is common and is not harmful.

Q. Will Adcapone make me sleepy?

The combined use of Adcapone and levodopa has been associated with cases of excessive daytime sleepiness and sudden sleep onset episodes. If you experience these symptoms, then you should neither drive nor operate other complex machinery. Consult your doctor if it becomes troublesome.

Q. What is meant by impulse control disorder caused by Adcapone?

In impulse control disorders, you may get urges or cravings to behave in ways that are unusual for you. In such disorders, you cannot resist the impulse, drive or temptation to carry out certain activities that could harm yourself or others. Additionally, it may include addictive gambling, excessive eating or spending, an abnormally high sex drive or a preoccupation with an increase in sexual thoughts or feelings. In such a case, your doctor may suggest dose reduction or discontinuation of dose.

Q. What if I accidentally take more than the recommended doses of Adcapone?

In case you take more than the recommended doses of Adcapone, you may experience confusion, decreased activity, sleepiness, decreased muscle tone, skin discoloration, and urticaria. If any such symptoms occur, you should seek immediate medical attention in a nearby hospital or contact your doctor.

Q. Does Adcapone cross the blood-brain barrier?

No, Adcapone does not cross the blood-brain barrier. It is useful in prolonging the duration of the benefit obtained from individual doses of levodopa.

Q. Does Adcapone affect fertility?

No, Adcapone does not affect fertility. However, it should be avoided by pregnant and lactating women because there is no sufficient data to support the safety of this patient group.

Q. When should I take entacapone?

Adcapone can be taken anytime but for better response it should be taken around the same time everyday. This also helps you to remember taking it.

Q. What type of drug is Adcapone?

Adcapone belongs to a class of medicines known as COMT (catechol-O-methyltransferase) inhibitors.

Q. Is Adcapone a dopamine agonist?

No, it is not a dopamine agonist. Adcapone is a selective and reversible inhibitor of COMT (catechol-O-methyltransferase) which works by increasing and maintaining sustained levels of levodopa when levodopa is given along with it.

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Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 473-74.
  2. Entacapone. Espoo, Finland: Orion Corporation; 2000 [revised Jun. 2014]. [Accessed 25 Mar. 2019] (online) Available from:External Link
  3. Entacapone. Newbury, Berkshire: Orion Pharma (UK) Limited; 1998 [revised 15 Dec. 2016]. [Accessed 28 Jan. 2019] (online) Available from:External Link
  4. Merello M, Lees AJ, Webster R, et al. Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 1994;57(2):186-89. [Accessed 19 Jun. 2019] (online) Available from:External Link
  5. Entacapone. North Ryde, New South Wales: Novartis Pharmaceuticals Australia Pty Limited; 2013. [Accessed 19 Jun. 2019] (online) Available from:External Link
  6. MedlinePlus. Entacapone. [Accessed on 25 Mar. 2019] (online) Available from:External Link
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90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
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