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MRP: Rs. 49899 for 1 vial(s) (1 injection each)
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Composition for ACTILYSE

Tissue Plasminogen Activator (Tpa)(50 mg)

food interaction for ACTILYSE

alcohol interaction for ACTILYSE

pregnancy interaction for ACTILYSE

lactation interaction for ACTILYSE

It can be taken with or without food, but it is better to take Actilyse 50mg injection at a fixed time.
Interaction with alcohol is unknown. Please consult your doctor.
Actilyse 50mg injection may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Actilyse 50mg injection is probably safe to use during breastfeeding. Please consult your doctor.


Tissue Plasminogen Activator (Tpa)(50 mg)


Tissue plasminogen activator is used for the treatment of acute ischemic stroke (insufficient blood supply to any part of brain), acute myocardial infarction (heart attack), and acute massive pulmonary embolism (blockage of a blood vessel in the lungs due to clot formation).

How it works

Tissue plasminogen activator belongs to a class of medications called fibrinolytics or thrombolytics. It breaks down and dissolves blood clots by increasing formation of clot dissolving protein (plasmin) thereby, releasing the blockage in the blood vessels and improving blood flow.

Common side effects

Blood in urine, Bruise, Chest pain, Decreased blood pressure, Gastrointestinal bleeding, Injection site bleeding


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Expert advice for ACTILYSE

  • Seek immediate medical advice if you experience signs and symptoms of bleeding such as pink or brown colour urine, blood in stools, black stools, coughing blood, vomiting blood or vomiting clotted blood (looks like coffee grounds), headache or any other signs and symptoms of stroke.
  • Stop the medication and contact your doctor immediately if you notice skin reactions (pale red, raised skin rashes), sudden fall in blood pressure, difficulty in breathing, fluid accumulation and swelling of eyes, lips, tongue etc.
  • Tell your doctor if you have had any surgery recently or planning to have one.
  • Inform your doctor if you have recently had any trauma (biopsies, intramuscular injection etc.), or conditions that can cause internal bleeding (bleeding in brain, digestive or reproductive system, eye) or external bleeding or if you have been diagnosed with severe blood clotting conditions (septic thrombophlebitis) or if you are taking any medications for prevention of blood clots (such as warfarin).
  • Tell your doctor if you have high blood pressure, heart disorders (acute pericarditis, bacterial endocarditis, mitral stenosis with arterial fibrillation), liver or kidney problems or any other bleeding disorders.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
  • Do not take if you are allergic to tissue plasminogen activator or any of its ingredients.
  • Do not give to Children, adolescents (aged below 18 years), and patients older than 80 years.
  • Do not give to patients with high risk of bleeding (those who have active internal bleeding, bleeding in brain, recent surgeries or trauma related to brain or spinal cord, some cancers, some abnormalities of blood vessels like, arteriovenous malformations, or aneurysms, patients receiving medications for blood clot prevention such as warfarin).
  • Do not give to patients with uncontrolled high blood pressure.
  • Do not give to patients with history of stroke or stroke due to bleeding in the brain (hemorrhagic stroke).
  • Do not give to patients with abnormal susceptibility to bleed (hemorrhagic diathesis).
  • Do not give to patients with inflammation of pancreas or coverings of the heart (bacterial endocarditis, pericarditis).
  • Do not give to patients with ulcers in the stomach or intestine.
  • Do not take if you are suffering from liver disease (such as hepatic failure, cirrhosis, portal hypertension, and hepatitis).
  • Do not take if you have received an external heart massage in the past 10 days.


Content on this page was last updated on 16 March, 2015, by Dr. Varun Gupta (MD Pharmacology)