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Actilyse 50mg Injection

Alteplase (50mg)

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Actilyse 50mg Injection is a medicine which dissolves the clots that have formed in blood vessels. It is used to treat stroke, heart attack, and pulmonary embolism (blood clots in the lungs). It is known as a thrombolytic or “clot-busting” medicine.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)

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General Information

Storage

Store below 30°C

The content is shown in English

Product introduction

Actilyse 50mg Injection is given directly into a vein by a doctor as soon as possible after the first signs of a heart attack, stroke, or pulmonary embolism are noticed. Your breathing, blood pressure, oxygen levels and other vital signs will be watched closely. You may be given another medicine to prevent the formation of new blood clots at the same time or after the treatment.

Actilyse 50mg Injection may cause confusion, nausea, and vomiting. It has many serious side effects. The most common and serious side effect of this medicine is bleeding. Treatment with this drug can lead to bleeding in the brain (cerebral hemorrhage), extremely low blood pressure (shock), and cardiac arrest (where your heart stops beating). Your treatment may be stopped if any of these happen. Talk to your doctor about the risk of serious side effects before you are given this medicine.

This medicine is not suitable for everyone. There is a long list of situations where you will not be given Actilyse 50mg Injection including if you have had a head injury, surgery of your brain or spinal cord, and any current bleeding anywhere in your body. Your healthcare team will need to know a lot about your medical history before giving you this medicine.

Uses of Actilyse Injection

Benefits of Actilyse Injection

Treatment of Heart attack
Actilyse 50mg Injection dissolves harmful blood clots that cause heart attack (if they are in the heart). They also dissolve clots that form in other blood vessels. This means that blood can again start to flow freely through your body. This medicine will, therefore, reduce both the damage caused by, and the risk of dying from a heart attack. The sooner the injection is given, the greater are the chances of recovery.

Treatment of Pulmonary embolism
Pulmonary embolism refers to clotting of blood in your lungs. Actilyse 50mg Injection prevents this clot formation in your lungs. This helps the blood flow freely around your body thereby preventing a heart attack or stroke. It prevents the formation of blood clots and also prevents the existing ones from growing bigger in size. Make appropriate lifestyle changes (such as eating healthy and staying active) to maximize the effectiveness of this medicine. Follow your doctor’s instructions carefully to get maximum benefit.

Treatment of Ischemic stroke
Actilyse 50mg Injection is sometimes called a “clot-buster” because it dissolves harmful blood clots that cause strokes (if they are in the brain). This helps the blood flow freely around your body thereby reducing the damage caused by and the future risk of stroke. It should be given as soon as possible after the onset of stroke.

Side effects of Actilyse Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Actilyse

Bleeding
Nausea
Vomiting
Confusion

How to use Actilyse Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Actilyse Injection works

Actilyse 50mg Injection is a thrombolytic medication. It works by dissolving the harmful blood clots in the blood vessels. This restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.

Quick tips

It should be given as soon as possible (within 12 hours) after the onset of a heart attack or within 4.5 hours of onset of stroke.
Let your doctor know immediately if you develop any nosebleeds, gum bleeding, black or tarry stools, or bruising.
Do not discontinue the medicines started after this injection as it may increase your chances of having another heart attack or stroke.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Actilyse 50mg Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Actilyse 50mg Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Actilyse 50mg Injection may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

NOT RELEVANT

Not relevant, as Actilyse 50mg Injection is intended for use in hospitalized patients.

Kidney

SAFE IF PRESCRIBED

Actilyse 50mg Injection is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Actilyse 50mg Injection in patients with liver disease.

Interaction with drugs

Taking Actilyse with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Apixaban (Oral Route)

Do not consume Apixaban with Alteplase. If concurrent use is essential, watch out for bleeding and consult your doctor immediately. Alteplase may increase the effect of Apixaban.

Moderate

Ticagrelor (Oral Route)

Talk to your doctor if you notice any unusual symptoms.

Moderate

Rivaroxaban (Oral Route)

Talk to your doctor if you notice any unusual symptoms.

Moderate

Tranexamic Acid (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Tranexamic Acid may block the action of Alteplase.

Moderate

Tirofiban (Injection Route)

Do not consume Tirofiban with Alteplase. If concurrent use is essential, watch out for bleeding and consult your doctor immediately.

Frequently asked questions

How is Actilyse 50mg Injection administered?

Actilyse 50mg Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Actilyse 50mg Injection.

Is Actilyse 50mg Injection safe?

Actilyse 50mg Injection is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.

Can the use of Actilyse 50mg Injection increase the risk of bleeding?

Yes, Actilyse 50mg Injection can increase the risk of bleeding. Always be careful while doing activities that may cause an injury or bleeding. Tell your doctor immediately if you notice any abnormal bruising or bleeding.

What medicines should I avoid while taking Actilyse 50mg Injection?

Actilyse 50mg Injection can interact with several medicines. If you are already taking Actilyse 50mg Injection, do not take any other medicine without talking to your doctor.

When will I feel better after taking Actilyse 50mg Injection?

Actilyse 50mg Injection reduces your risk of developing blood clots in the blood vessels of your leg, lungs, heart and brain. You may not feel any difference after taking Actilyse 50mg Injection. This does not mean that the medicine is not working, therefore keep taking this medicine as prescribed.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Plasminogen Activators- Thrombolytics

Related lab tests

Platelet Count

References

Weitz JI. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 866.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 45-47.
Fox KA, White HD, Gersh BJ, et al. Antithrombotic Agents: Platelete Inhibitors, Acute Anticoagulants, Fibrinolytics, and Chronic Anticoagulants. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. p. 382.
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Alteplase. [Updated 2018 Dec 3]. [Accessed 19 Feb. 2020] (online) Available from:

User feedback

What are you using Actilyse Injection for?

Stroke

33%

Heart attack

30%

Ischemic stroke

28%

Others

How much was the improvement?

Average

40%

Excellent

40%

Poor

20%

What were the side-effects while using Actilyse 50mg Injection?

Nausea

27%

Vomiting

20%

Injection site bleeding

20%

Decreased blood pressure

13%

No Side Effect

13%

How do you take Actilyse Injection?

With or without food

57%

With food

29%

Empty stomach

14%

Please rate Actilyse 50mg Injection on price

Expensive

76%

Not Expensive

14%

Average

10%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Boehringer Ingelheim
Address: 1102, Hallmark Business Plaza, 11th Floor, Gurunanak Hospital Road, Near Gurunanak Hospital, Bandra (East), Mumbai 400051

Vendor Details

Country of origin: Germany
A licensed vendor partner from your nearest location will deliver Actilyse 50mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Why we need a prescription?

Actilyse 50mg Injection

Payment

Return

Expiry after

Save more with additional offers

General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Actilyse Injection

Benefits of Actilyse Injection

Side effects of Actilyse Injection

How to use Actilyse Injection

How Actilyse Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Apixaban (Oral Route)

Ticagrelor (Oral Route)

Rivaroxaban (Oral Route)

Tranexamic Acid (Oral Route)

Tirofiban (Injection Route)

Frequently asked questions

How is Actilyse 50mg Injection administered?

Is Actilyse 50mg Injection safe?

Can the use of Actilyse 50mg Injection increase the risk of bleeding?

What medicines should I avoid while taking Actilyse 50mg Injection?

When will I feel better after taking Actilyse 50mg Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Platelet Count

References

User feedback

What are you using Actilyse Injection for?

How much was the improvement?

What were the side-effects while using Actilyse 50mg Injection?

How do you take Actilyse Injection?

Please rate Actilyse 50mg Injection on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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