Author Details
Written By
MDS (Oral Pathology & Microbiology), BDS
Reviewed By
MD (Pharmacology), MBBS
Last updated
29 Nov 2023 | 06:55 PM (IST)

We provide you with authentic, trustworthy and relevant information

Want to know more

Have issue with the content?

Report Problem

Actilyse 20mg Injection

Prescription Required
SALT COMPOSITION
Salt Synonyms
Recombinant tissue plasminogen activator
Storage
Store below 30°C

Product introduction

Actilyse 20mg Injection is a medicine which dissolves the clots that have formed in blood vessels. It is used to treat stroke, heart attack, and pulmonary embolism (blood clots in the lungs). It is known as a thrombolytic or “clot-busting” medicine.

Actilyse 20mg Injection is given directly into a vein by a doctor as soon as possible after the first signs of a heart attack, stroke, or pulmonary embolism are noticed. Your breathing, blood pressure, oxygen levels and other vital signs will be watched closely. You may be given another medicine to prevent the formation of new blood clots at the same time or after the treatment.

Actilyse 20mg Injection may cause confusion, nausea, and vomiting. It has many serious side effects. The most common and serious side effect of this medicine is bleeding. Treatment with this drug can lead to bleeding in the brain (cerebral hemorrhage), extremely low blood pressure (shock), and cardiac arrest (where your heart stops beating). Your treatment may be stopped if any of these happen. Talk to your doctor about the risk of serious side effects before you are given this medicine.

This medicine is not suitable for everyone. There is a long list of situations where you will not be given Actilyse 20mg Injection including if you have had a head injury, surgery of your brain or spinal cord, and any current bleeding anywhere in your body. Your healthcare team will need to know a lot about your medical history before giving you this medicine.

Benefits of Actilyse Injection

In Treatment of Heart attack

Actilyse 20mg Injection dissolves harmful blood clots that cause heart attack (if they are in the heart). They also dissolve clots that form in other blood vessels. This means that blood can again start to flow freely through your body. This medicine will, therefore, reduce both the damage caused by, and the risk of dying from a heart attack. The sooner the injection is given, the greater are the chances of recovery.

In Treatment of Ischemic stroke

Actilyse 20mg Injection is sometimes called a “clot-buster” because it dissolves harmful blood clots that cause strokes (if they are in the brain). This helps the blood flow freely around your body thereby reducing the damage caused by and the future risk of stroke. It should be given as soon as possible after the onset of stroke.

In Treatment of Pulmonary embolism

Pulmonary embolism refers to clotting of blood in your lungs. Actilyse 20mg Injection prevents this clot formation in your lungs. This helps the blood flow freely around your body thereby preventing a heart attack or stroke. It prevents the formation of blood clots and also prevents the existing ones from growing bigger in size. Make appropriate lifestyle changes (such as eating healthy and staying active) to maximize the effectiveness of this medicine. Follow your doctor’s instructions carefully to get maximum benefit.

Side effects of Actilyse Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Actilyse

  • Bleeding
  • Nausea
  • Vomiting
  • Confusion

How to use Actilyse Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Actilyse Injection works

Actilyse 20mg Injection is a thrombolytic medication. It works by dissolving the harmful blood clots in the blood vessels. This restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.

Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Actilyse 20mg Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Actilyse 20mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Actilyse 20mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
NOT RELEVANT
Not relevant, as Actilyse 20mg Injection is intended for use in hospitalised patients.
Kidney
SAFE IF PRESCRIBED
Actilyse 20mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Actilyse 20mg Injection may not be needed in these patients. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Actilyse 20mg Injection in patients with liver disease. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine

Quick tips

  • It should be given as soon as possible (within 12 hours) after the onset of a heart attack or within 4.5 hours of onset of stroke.
  • Let your doctor know immediately if you develop any nosebleeds, gum bleeding, black or tarry stools, or bruising. 
  • Do not discontinue the medicines started after this injection as it may increase your chances of having another heart attack or stroke.

Fact Box

Chemical Class
Carboxylic Acids Derivatives
Habit Forming
No
Therapeutic Class
CARDIAC
Action Class
Plasminogen Activators- Thrombolytics

Patient concerns

arrow
In road accident head and small intestine got injured . 15 stiches on head and operation of 1 inch diameter of intestine . Now spo2 level is dropping to 70% after 1 hour of removing oxygen mask
Dr. Saurabh Arora
Cardiology
Get checked for pulmonary embolism or pneumothorax
Fast symbol of heart attack and stroke
Dr. Nabajit Talukdar
Cardiology
risk factors undue fatigue chest pain etc
arrow

User feedback


FAQs

Q. How is Actilyse 20mg Injection administered?

Actilyse 20mg Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Actilyse 20mg Injection.

Q. Is Actilyse 20mg Injection safe?

Actilyse 20mg Injection is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.

Q. Can the use of Actilyse 20mg Injection increase the risk of bleeding?

Yes, Actilyse 20mg Injection can increase the risk of bleeding. Always be careful while doing activities that may cause an injury or bleeding. Tell your doctor immediately if you notice any abnormal bruising or bleeding.

Q. What medicines should I avoid while taking Actilyse 20mg Injection?

Actilyse 20mg Injection can interact with several medicines. If you are already taking Actilyse 20mg Injection, do not take any other medicine without talking to your doctor.

Q. When will I feel better after taking Actilyse 20mg Injection?

Actilyse 20mg Injection reduces your risk of developing blood clots in the blood vessels of your leg, lungs, heart and brain. You may not feel any difference after taking Actilyse 20mg Injection. This does not mean that the medicine is not working, therefore keep taking this medicine as prescribed.
Related lab tests

Want to share the information?

Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Weitz JI. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 866.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 45-47.
  3. Fox KA, White HD, Gersh BJ, et al. Antithrombotic Agents: Platelete Inhibitors, Acute Anticoagulants, Fibrinolytics, and Chronic Anticoagulants. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. p. 382.
  4. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Alteplase. [Updated 2018 Dec 3]. [Accessed 19 Feb. 2020] (online) Available from:External Link

Marketer details

Name: Boehringer Ingelheim
Address: 1102, Hallmark Business Plaza, 11th Floor, Gurunanak Hospital Road, Near Gurunanak Hospital, Bandra (East), Mumbai 400051
Country of origin: Germany

22692
Inclusive of all taxes
MRP23899  5% OFF
20.0 ml in 1 bottle
SOLD OUT
Notify me

INDIA’S LARGEST HEALTHCARE PLATFORM

260m+
Visitors
31m+
Orders Delivered
1800+
Cities
Get the link to download App
Reliable

All products displayed on Tata 1mg are procured from verified and licensed pharmacies. All labs listed on the platform are accredited

Secure

Tata 1mg uses Secure Sockets Layer (SSL) 128-bit encryption and is Payment Card Industry Data Security Standard (PCI DSS) compliant

Affordable

Find affordable medicine substitutes, save up to 50% on health products, up to 80% off on lab tests and free doctor consultations.

LegitScript approved
India's only LegitScript and ISO/ IEC 27001 certified online healthcare platform

Know more about Tata 1mgdownArrow

Access medical and health information

Tata 1mg provides you with medical information which is curated, written and verified by experts, accurate and trustworthy. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies.

Order medicines online

Get free medicine home delivery in over 1800 cities across India. You can also order Ayurvedic, Homeopathic and other Over-The-Counter (OTC) health products. Your safety is our top priority. All products displayed on Tata 1mg are procured from verified and licensed pharmacies.

Book lab tests

Book any lab tests and preventive health packages from certified labs and get tested from the comfort of your home. Enjoy free home sample collection, view reports online and consult a doctor online for free.

Consult a doctor online

Got a health query? Consult doctors online from the comfort of your home for free. Chat privately with our registered medical specialists to connect directly with verified doctors. Your privacy is guaranteed.