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Actiful 5 Tablet

Written By Dr. Syeda Aafia, MBA, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 31 Mar 2026 | 02:32 PM (IST)
Actiful 5 Tablet is used to treat low blood pressure (hypotension). It is used in patients who experience dizziness due to low blood pressure while standing up suddenly from a sitting or lying position. This medicine causes tightening of blood vessels and results in an elevation of your blood pressure.
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General Information

Contains

Midodrine (5mg)

Marketer

Tas Med India Pvt Ltd

Storage

Store below 25°C
The content is shown in English
Actiful 5 Tablet image
Actiful 5 Tablet image
Actiful 5 Tablet image
Actiful 5 Tablet image

Product introduction

Actiful 5 Tablet can be taken with or without food. This medicine is taken during daytime hours when people stand most often. However, it should not be taken if you are going to lie down for a long time after a dose. Headache, blurred vision, nausea, heartburn and difficulty in urination may be seen as side effects in some patients.

Uses of Actiful Tablet

  • Treatment of Low blood pressure

Benefits of Actiful Tablet

Treatment of Low blood pressure
Actiful 5 Tablet is used in adults to relieve low blood pressure, which may occur due to a sudden change in posture from lying to sitting or standing up (orthostatic hypotension), during an operation, or after an injury. This medicine helps bring the blood pressure within the normal range. It therefore prevents any sudden fall or even serious complications that might have otherwise followed due to low blood pressure.

Side effects of Actiful Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Actiful
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Headache
  • Nausea
  • Rash
  • Difficulty in urination
  • Supine hypertension
  • Urinary retention
  • Goosebumps

How to use Actiful Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Actiful 5 Tablet may be taken with or without food.

How Actiful Tablet works

Actiful 5 Tablet is an alpha-adrenergic agonist. It works by activating specific receptors on blood vessels. This causes the blood vessels to tighten, which increases blood pressure.

All substitutes for Actiful 5 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Midorise 5 Tablet

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Cipmido 5mg Tablet

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â‚ą62.1/tablet
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<h3 class=bodySemiBold>Cipmido 5mg Tablet</h3>

Midgeo 5mg Tablet

by Centaur Pharmaceuticals Pvt Ltd
â‚ą46.6/tablet
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<h3 class=bodySemiBold>Midgeo 5mg Tablet</h3>

Inramed 5 Tablet

by Mylan Pharmaceuticals Pvt Ltd - A Viatris Company
â‚ą76.2/tablet
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<h3 class=bodySemiBold>Inramed 5 Tablet</h3>

Xidorin 5 Tablet

by Sun Pharmaceutical Industries Ltd
â‚ą80.8/tablet
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Quick tips

  • Take Actiful 5 Tablet at least 4 hours before bedtime to avoid the risk of high blood pressure at night time. 
  • Monitor your blood pressure regularly while taking this medicine. 
  • Inform your doctor if you have a history of prostate disorder or blood circulation problems.
  • Inform your doctor immediately if you notice symptoms of chest pain, palpitations, headache, shortness of breath, and blurred vision.
  • Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Actiful 5 Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Actiful 5 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Actiful 5 Tablet during breastfeeding is not available. Please consult your doctor.
Driving

Driving

CAUTION
Actiful 5 Tablet may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Actiful 5 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Actiful 5 Tablet in patients with liver disease.

Interaction with drugs

Taking Actiful with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Risperidone (Oral Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your liver function. Midodrine may raise blood levels of the active form of Risperidone.
Moderate

Selegiline (Oral Route)

Do not consume Selegiline with Midodrine. If concurrent use is essential, your doctor may monitor your blood pressure frequently.
Moderate

Rasagiline (Oral Route)

If concurrent use is essential, your doctor may monitor your blood pressure frequently.
Moderate

Risperidone (Injection Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your liver function. Midodrine may raise blood levels of the active form of Risperidone.
Moderate

Safinamide (Oral Route)

If concurrent use is essential, your doctor may monitor your blood pressure frequently.

Frequently asked questions

Yes, Actiful 5 Tablet may cause high blood pressure when you are lying flat on your back (supine hypertension). This medicine should only be used by people whose low blood pressure affects their day-to-day lives and in people who cannot be treated successfully with other therapies.
Actiful 5 Tablet may slow down the heart rate slightly. It should be used cautiously when used with other medicines (beta blockers, digitalis, etc.), which can further slow down the heart rate. Patients should be monitored if they experience symptoms that are suggestive of a slow heart rate.
You should not lie down immediately after taking Actiful 5 Tablet because of the risk of supine hypertension (high blood pressure, which occurs when you are lying flat on your back). Therefore, it is recommended to take the last daily dose at least 4 hours before bedtime. To lower the chance of high blood pressure while lying down at night, try keeping your head raised.
Actiful 5 Tablet takes about 1 hour to show its effects. However, the action lasts for a short time only, the effect persists for about 2-3 hours.
Actiful 5 Tablet should be taken exactly as directed by your doctor. Actiful 5 Tablet is taken orally with or without food. Swallow Actiful 5 Tablet as a whole with a glass of water. Usually, it is advised to take the medicine three times a day [morning, midday, and late afternoon (before 6 pm)] with a gap of at least 3 hours. Take the last daily dose of Actiful 5 Tablet before an evening meal and at least 4 hours before bedtime.
Actiful 5 Tablet is not advised for patients having an allergy to any component of the product, severe heart disease, unusually slow heart rate, high blood pressure, or conditions causing tightening of the arteries. Along with that, treatment with Actiful 5 Tablet should be avoided if the patient has an enlarged prostate gland, urinary retention (when the bladder can’t empty properly), pheochromocytoma (tumor of the adrenal medulla), acute or severe kidney disease, overactive thyroid, poor vision as a result of diabetes, and narrow-angle glaucoma (elevated pressure in the eye).
You may need to check your blood pressure and get your kidney and liver function tests done before you start taking Actiful 5 Tablet. Once you begin the treatment, keep a constant track of your blood pressure and heart rate, especially after lying down.
Symptoms of supine hypertension include chest pain, palpitations, shortness of breath, headache, and blurred vision. If you develop these symptoms, tell your doctor immediately. The doctor may reduce the dose of Actiful 5 Tablet or may discontinue treatment if the symptoms persist.
Using Actiful 5 Tablet and metoprolol together can make your heart rate considerably slow. Hence, you need to be careful while using both together. If you experience slow pulse, dizziness, and fainting, inform your doctor as the dose of these medicines may need to be modified.

Fact Box

Chemical Class

Dimethoxybenzenes

Habit Forming

No

Therapeutic Class

CARDIAC

Action Class

Alpha-1 adrenoreceptor agonists

References

  1. Westfall TC, WestfallIn DP. Adrenergic Agonists and Antagonists. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 295.
  2. Biaggioni I, Robertson D. Adrenoreceptor Agonists & Sympathomimetic Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 139.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 915-16.
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
  5. Midodrine hydrochloride [Product Information]. Lower Parel, Mumbai: CiplaMed; 2023. [Accessed 05 Mar. 2025] (online) Available from:
  6. Midodrine Hydrochloride [Product Information]. Dublin, OH: Cardinal Health; 2024. [Accessed 05 Mar. 2025] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Tas Med India Pvt Ltd
Address: Plot No. 45, N.T.M., Sector -26, Chandigarh

Vendor Details

Country of origin: India

Lab tests offered by us

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