Information about Midodrine

Midodrine Uses

Midodrine is used in the treatment of Low blood pressure.

How Midodrine works

Midodrine is an alpha-adrenergic agonist. It works by activating specific receptors on blood vessels. This causes the blood vessels to tighten, which increases blood pressure.

Common side effects of Midodrine

Difficulty in urination, Headache, Nausea, Heartburn
Written By
Reviewed By
MD (Pharmacology), MBBS
Last updated:
14 Mar 2020 | 11:28 AM (UTC)
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Available Medicine for Midodrine

InramedMylan Pharmaceuticals Pvt Ltd
9500 to ₹120002 variant(s)
GutronBluemed Pharma Pvt Ltd
25001 variant(s)

Expert advice for Midodrine

  • Take Midodrine at least 4 hours before bedtime to avoid the risk of high blood pressure at night time. 
  • Monitor your blood pressure regularly while taking this medicine. 
  • Inform your doctor if you have a history of the prostate disorder or blood circulation problem. 
  • Inform your doctor immediately if you notice symptoms of chest pain, palpitations, headache, shortness of breath, and blurred vision.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Frequently asked questions for Midodrine


Q. Does Midodrine raise blood pressure?

Yes, Midodrine may cause high blood pressure when you are lying flat on your back (supine hypertension). This medicine should only be used by people whose low blood pressure affects their day-to-day life and in people who could not be treated successfully with other therapies.

Q. Does Midodrine affect heart rate?

Midodrine may slow down the heart rate slightly. It should be used cautiously when using it with other medicines (beta blockers, digitalis, etc.) which can further slow down the heart rate. Patients should be monitored if they experience symptoms which are suggestive of slow heart rate.

Q. Why can't I lie down after taking Midodrine?

You should not lie down immediately after taking Midodrine because of the risk of supine hypertension (high blood pressure which occurs when you are lying flat on your back). Therefore, it is recommended to take the last daily dose at least 4 hours before bedtime. You can reduce the risk of supine hypertension occurring during the night by elevating the head.

Q. Does Midodrine work immediately?

Midodrine takes about 1 hour to show its effects. However, the action lasts for a short time only, the effect persists for about 2-3 hours.

Q. How do I take Midodrine?

Midodrine should be taken exactly as directed by your doctor. Midodrine is taken orally with or without food. Swallow the tablet as a whole with a glass of water. Usually, it is advised to take the medicine three times a day (morning, midday, and late afternoon [before 6PM]) with a gap of at least 3 hours. Take the last daily dose of Midodrine before an evening meal and at least 4 hours before bedtime.

Q. Who should not take Midodrine?

Midodrine is not advised for patients having allergy to any component of the product, severe heart disease, unusually slow heart rate, high blood pressure, and conditions causing tightening of the arteries. Along with that, treatment with Midodrine should be avoided if the patient has enlarged prostate gland, urinary retention (when the bladder can’t empty properly), pheochromocytoma (tumour of the adrenal medulla), acute or severe kidney disease, overactive thyroid, poor vision as a result of diabetes, and narrow-angle glaucoma (elevated pressure in the eye).

Q. Is any monitoring required during Midodrine treatment?

You may need to check your blood pressure and get your kidney and liver function tests done before you start taking Midodrine. Once you begin the treatment, keep a constant track of your blood pressure and heart rate, especially after lying down.

Q. How will I know that I have developed supine hypertension?

Symptoms of supine hypertension include chest pain, palpitations, shortness of breath, headache, and blurred vision. If you develop these symptoms tell your doctor immediately. The doctor may reduce the dose of Midodrine or may discontinue treatment if the symptoms persists.

Q. Can I take metoprolol with Midodrine?

Using Midodrine and metoprolol together can make your heart rate considerably slow. Hence, you need to be careful while using both together. If you experience slow pulse, dizziness and fainting, inform your doctor as the dose of these medicines may need to be modified.


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