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Tretin 0.025% Cream

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 16 Mar 2026 | 04:08 PM (IST)
Tretin 0.025% Cream is a form of vitamin A that is used to treat acne, which appears as spots or pimples on your face, chest, or back. It also helps to smooth rough facial skin and to reduce fine wrinkles on the skin.
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Tretin 0.025% Cream image
Tretin 0.025% Cream image
Tretin 0.025% Cream image
Tretin 0.025% Cream image

Product introduction

Tretin 0.025% Cream reduces the excessive oil production of the skin. Ideally, a pinpoint application at nighttime is recommended for the duration prescribed by your doctor. The amount you need and for how long you need to take it will depend on what you are being treated for. You should normally wash and dry the affected area before applying a thin layer of this medicine. Follow your doctor’s instructions.


Do not apply Tretin 0.025% Cream to damaged or broken skin, and avoid contact with your mouth, eyes, and nose. It may take several weeks for your symptoms to improve, but keep using it regularly to get the most benefit. Consult your doctor again if you do not notice any improvement after a few weeks. Using more medicine or applying it more often than prescribed will not make it work any faster and may increase the side effects.


The most common side effects include irritation, dryness, and redness of the skin. They are usually mild and improve as your body gets used to the medicine. Drink plenty of water and use moisturizer, as it may lead to dryness of the mouth, lips, and eyes. Let your doctor know if these side effects bother you or do not go away. Serious side effects with this medicine are rare.


Tretin 0.025% Cream may make you more sensitive to sunlight, so you should limit exposure to the sun if possible. It may make your skin more fragile. It is advised not to have any waxing (hair removal) or laser treatments during treatment. Pregnant women or women who are planning to get pregnant should not use this medicine, as it can lead to birth defects.

Uses of Tretin Cream

Benefits of Tretin Cream

Treatment of Acne
Tretin 0.025% Cream is a form of vitamin A. It helps treat acne by clearing skin pores and preventing spots or pimples from appearing. It usually takes several weeks to have a noticeable effect so keep using it even if it appears not to be working. Sometimes acne may get worse before it gets better, however, with proper use, your skin will get clearer. The earlier you start using it, the less likely you are to get scars. This medicine will help improve your mood and uplift your confidence as your skin becomes acne-free. It should not be used if you have eczema or sunburned skin.

Side effects of Tretin Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tretin
  • Erythema (skin redness)
  • Increased sensitivity to light
  • Skin irritation
  • Dry skin

How to use Tretin Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Tretin Cream works

Tretin 0.025% Cream is a form of vitamin A. When applied on the skin, it reduces oil production in the skin, replenishes acne-prone skin, and helps keep your pores open.

All substitutes for Tretin 0.025% Cream

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Clean the affected area with water and a non-medicated soap. Let it dry for 20-30 minutes before applying Tretin 0.025% Cream.
  • Tretin 0.025% Cream may increase the severity of the spots or pimples in the first few weeks of use. Continue using it as prescribed by your doctor.
  • It may cause a stinging sensation or a feeling of warmth when you first start using it. Inform your doctor if this persists.
  • Avoid exposure to sunlight while using Tretin 0.025% Cream as it increases the sensitivity of your skin. Use protective measures such as sunscreen or protective clothing.
  • Avoid face waxing and laser treatment while using this medicine, as it makes your skin more fragile.
  • Avoid taking tetracycline (e.g., doxycycline) as it may reduce the Tretin 0.025% Cream activity.
  • Inform your doctor if excessive skin dryness or skin sensitivity occurs.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

UNSAFE
Tretin 0.025% Cream is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Tretin 0.025% Cream may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Driving

Driving

No interaction found/established
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established

Interaction with drugs

Taking Tretin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Minocycline (Skin Route)

Please consult with your doctor regarding an appropriate time gap between both medicines.
Moderate

Vitamin A (Injection Route)

Please consult with your doctor.
Moderate

Vitamin A (Oral Route)

Please consult with your doctor.
Moderate

Fluconazole (Skin Route)

Please consult with your doctor regarding an appropriate time gap between both medicines.
Moderate

Ketoconazole (Skin Route)

Please consult with your doctor regarding an appropriate time gap between both medicines.

Frequently asked questions

Your doctor will decide whether you can continue taking or stop taking Tretin 0.025% Cream before cosmetic procedures. However, it is advised not to undergo hair removal or laser treatments while using Tretin 0.025% Cream. Please inform your doctor about all the medicines you are taking before starting the treatment with this medicine. Also, consult the doctor before starting any cosmetic procedure.
Yes, Tretin 0.025% Cream is safe to use when taken as advised by your doctor. However, like all medicines, even this medicine has some side effects, but it is not necessary that anyone who is taking this medicine will get these side effects. Please talk to your doctor if you get any unpleasant effects while taking this medicine.
Your doctor will decide the duration of your treatment depending on the severity of your disease and the results of your lab tests. Usually, the treatment with Tretin 0.025% Cream takes around 4-5 months.
It is important to consult your doctor if you are planning to become pregnant while using Tretin 0.025% Cream. Ideally, pregnancy is not advised because this medicine can harm your baby. However, if you do get pregnant during the treatment with Tretin 0.025% Cream, consult your doctor.
One of the most common side effects of Tretin 0.025% Cream includes dryness of the skin, nose, and lips. Tretin 0.025% Cream reduces the secretion of oil, which results in skin dryness. Dryness due to Tretin 0.025% Cream can be managed by applying moisturizers or lubricants like Vaseline. You can also apply lip balm to relieve cracked and dry lips. Drink enough water to keep your body hydrated.

Fact Box

Chemical Class

Retinoids

Habit Forming

No

Therapeutic Class

DERMA

Action Class

First-Generation Retinoids

References

  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1395-98.
  2. Tretinoin [Prescribing Information]. Mumbai, Maharashtra: Johnson & Johnson Private Limited; 2012. [Accessed 24 Mar. 2024] (online) Available from:
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User feedback

Once A Day
80%
Twice A Day
20%
Acne
70%
Others
30%
Average
41%
Poor
37%
Excellent
22%
No Side Effect
49%
Dryness
21%
Skin irritation
11%
Erythema (skin redness)
8%
Application site pain
3%
With or without food
58%
With food
32%
Empty stomach
9%
Average
41%
Expensive
36%
Not Expensive
24%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Hegde and Hegde Pharmaceutica LLP
Address: 301. Om Chambers, 123 August Kranti Marg Kemps Corner, Mumbai-400036

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Tretin 0.025% Cream. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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