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Trespin 300mg Respules

Tobramycin (300mg)
Genuine
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required
Cold stored
Stored between 2-8°C
Trespin 300mg Respules is an antibiotic used to prevent or treat infections of the lung (e.g., pneumonia). It is particularly effective in managing lung infections in people suffering from a disease known as cystic fibrosis.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 10 Apr 2026 | 11:53 AM (IST)
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5 ml Respules
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General Information

Contains

Tobramycin (300mg)

Marketer

Fusion Healthcare Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Trespin 300mg Respules image
Trespin 300mg Respules image

Product introduction

Trespin 300mg Respules is only meant for inhalation using a nebulizer. The solution should not be injected or swallowed. It works by stopping the growth of bacteria. This helps to improve your symptoms and resolve the underlying infection. It should be used regularly at evenly spaced time intervals as prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening.

Common side effets of this medicine include increased may cause cough, pharyngitis, change in taste, or voice change as side effects in some patients. These are temporary and usually resolve with time. Regular rinsing of the mouth with warm saline water and the use of lozenges may help you to overcome the side effects. Consult your doctor if any of the side effects persist or if your condition does not improve.

Your doctor may advise you periodic blood counts and kidney function tests for monitoring. Inform your doctor if you are pregnant, planning to conceive, or breastfeeding before using this medicine. Let your doctor also know about all the other medications you are taking, if any.

Uses of Trespin Respules

  • Treatment of Bacterial eye infections
  • Treatment and prevention of Lung infections in patients with cystic fibrosis

Benefits of Trespin Respules

Treatment of Bacterial eye infections
Trespin 300mg Respules is an antibiotic medicine. It works by stopping the growth of the bacteria that is causing the infection. It helps relieve symptoms such as pain, redness, itching, or soreness caused due to eye infections. The dose and duration of treatment will be decided by your doctor based on your condition. Make sure you complete the full course of treatment. This will ensure that the infection is completely cured and prevent it from returning.
Treatment and prevention of Lung infections in patients with cystic fibrosis
People with cystic fibrosis (CF) are at greater risk of getting lung infections because thick, sticky mucus builds up in their lungs, allowing infectious bacteria to grow and multiply. Lung infections are a serious problem for such patients because they can lead to severe or worsening lung disease. Trespin 300mg Respules helps treat lung infections in such people and also improves lung function. This helps to prevent further complications and prolongs the life of CF patients. Follow your doctor’s instructions carefully to get the most benefit from Trespin 300mg Respules.

Side effects of Trespin Respules

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Trespin
  • Taste change
  • Lung disorder

How to use Trespin Respules

Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Twist off the top of the respule/transpule and squeeze all the liquid into the nebulizer. It should be used right away after opening.

How Trespin Respules works

Trespin 300mg Respules is an antibiotic. It stops bacterial growth in the airways by preventing synthesis of essential proteins required by bacteria to carry out vital functions. This treats infection in the airways.

All substitutes for Trespin 300mg Respules

For information purposes only. Consult a doctor before taking any medicine.

Tobamist Eco Pack (5ml Each) Respules

by Cipla Ltd
₹1694/respules
223% costlier
<h3 class=bodySemiBold>Tobamist Eco Pack (5ml Each) Respules</h3>

Tobamist Respules (5ml Each)

by Cipla Ltd
₹2935.05/respules
459% costlier
<h3 class=bodySemiBold>Tobamist Respules (5ml Each)</h3>

Quick tips

  • This medicine is for inhalation using a nebuliser only. The solution should not be injected or swallowed.
  • Take the first dose of this medicine under medical supervision as it may cause wheezing or tightening of the airways (bronchospasm) immediately after using.
  • Inform your doctor if you experience any hearing loss, sensation of ringing in the ears, or dizziness and unsteadiness.
  • Your doctor will regularly monitor your kidney function while taking Trespin 300mg Respules to detect any toxicity.
  • Do not skip any doses and finish the full course of treatment even if you feel better.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Trespin 300mg Respules. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Trespin 300mg Respules during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Trespin 300mg Respules during breastfeeding is not available. Please consult your doctor.
Driving

Driving

SAFE
Trespin 300mg Respules does not usually affect your ability to drive.
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established

Interaction with drugs

Taking Trespin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Tenofovir disoproxil fumarate (Oral Route)

Do not consume Tenofovir disoproxil fumarate with Tobramycin. If concurrent use is essential, your doctor may monitor your kidney function closely.
Severe

Vancomycin (Injection Route)

If concurrent use is essential, your doctor may closely monitor your kidney's functioning and overall treatment.
Severe

Carboplatin (Injection Route)

Your doctor may monitor your electrolyte levels, kidney function, and hearing ability along with your overall treatment.
Severe

Tacrolimus (Oral Route)

If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. They may adjust the doses as per the observations.
Severe

Colistin Sulphate (Injection Route)

Do not consume Colistin Sulphate with Tobramycin. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Frequently asked questions

Trespin 300mg Respules is given via a nebulizer for inhalation purpose. Your healthcare provider will teach you the method of taking it. Take it exactly as prescribed by your doctor. Use 2 single containers per day for 28 days. Inhale the contents of 1 container in the morning and one in the evening. After taking it for 28 days, stop for 28 days and then again take the medicine for 28 days. Maintain this 28 days on and 28 days off cycle. Try to keep the 2 doses 12 hours apart. Do not take your dose less than 6 hours apart.
Yes, Trespin 300mg Respules inhalation solution should be refrigerated at 2- 8°C/36-46°F. Upon removal from refrigeration or if refrigerator is unavailable, the solution pouches (opened/unopened) should be stored at room temperature (up to 25°C/77°F) for up to 28 days. It should not be exposed to intense light. Not storing it in the refrigerator may darken the medicine. However, color change does not indicate change in quality.
Yes, Trespin 300mg Respules belongs to aminoglycoside class of antibiotic medicine, which may affect the kidney function. However, there is no firm evidence to suggest so. If your kidney function is already impaired, then you should be careful while using Trespin 300mg Respules. Your doctor will get your kidney function tested before starting Trespin 300mg Respules and at regular intervals during treatment. Tell your doctor if you experience decreased urination, unusual tiredness or weakness or swelling of the face, arms, hands, feet, ankles, or lower legs.
Sometimes the bacteria gets modified in your body and the medicine no longer works. This is called drug resistance. Resistance can occur with Trespin 300mg Respules if it is used inappropriately, for example if you do not adhere to the dose and duration of therapy. It may also occur if you use it for viral and fungal infections instead of bacterial infections. Therefore, it is important that you continue taking Trespin 300mg Respules for the duration advised by your doctor even if you start feeling better.
Yes, you can take other inhaler medicines along with Trespin 300mg Respules but not simultaneously. If you are receiving several respiratory therapies, it is recommended that you adhere to the following order: bronchodilator, respiratory physiotherapy, other inhaled medicinal products and finally Trespin 300mg Respules. You should not mix other inhalation medicinal products with Trespin 300mg Respules. You should consult your doctor who will let you know when to take which medicine.
Trespin 300mg Respules is effective if used in the dose and duration advised by your doctor. Do not stop taking it even if you see improvement in your condition. If you stop using Trespin 300mg Respules too early, the symptoms may return or worsen.
Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform the doctor if your symptoms are getting worse while using this medicine.
No, do not stop taking Trespin 300mg Respules without consulting your doctor even if you are feeling better. Your symptoms may improve before the infection is completely cured. Therefore, for better and complete treatment, it is advised to continue your treatment for the prescribed duration.
No, Trespin 300mg Respules alone does not have steroids in it. It is an antibiotic, which means that it is effective against bacterial infections. It is not effective against viral or fungal infections and hence should not be used in these kinds of infections. Trespin 300mg Respules may be combined with steroids such as dexamethasone.
Trespin 300mg Respules is effective against a wide range of bacteria. Trespin 300mg Respules must be used only against susceptible bacteria. A whole gamut of bacteria that can be killed by Trespin 300mg Respules includes S. Aureus and S. epidermidis, some species of Streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris strains, Haemophilus influenza, and H. aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, and some Neisseria species. Your doctor will evaluate whether this medicine is suitable for your condition.
The doctor will decide the duration of treatment which will depend on the severity of infection. For instance, if you have mild to moderate eye infection, your doctor will advise 1-2 eye drops, 4 times a day, usually. In severe infections, you may be prescribed 2 drops every hour. Do not use more or less of it or use it more often than prescribed by your doctor. You should use it exactly as prescribed by your doctor.
You should wash your hands before using the eye drops. Avoid touching the dropper tip against your eye or anywhere else. Tilt your head slightly and instill one drop. Close your eyes for 2 or 3 minutes with your head tipped down, avoid blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct. If you use more than one drop, wait about 5 minutes between the drops. Wait at least 10 minutes before using any other eye drops your doctor has prescribed.
No, Trespin 300mg Respules alone does not have steroids in it. It is an antibiotic, which means that it is effective against bacterial infections. It is not effective against viral or fungal infections and hence should not be used in these kinds of infections. Trespin 300mg Respules may be combined with steroids such as dexamethasone.

Fact Box

Chemical Class

4,6- disubstituted 2- deoxystreptamines

Habit Forming

No

Therapeutic Class

ANTI INFECTIVES

Action Class

Bacterial Protein Synthesis Inhibitors- Aminoglycosides

References

  1. MacDougall C, Chambers HF. Aminoglycosides. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1516.
  2. Chambers HF, Deck DH. Aminoglycosides & Spectinomycin. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 812.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1371-72.
  4. Tobramycin. Netherlands: Sun Pharmaceutical Industries; 2017. [Accessed 31 Mar. 2019] (online) Available from:
  5. Tobramycin. Halol, Gujarat: Sun Pharmaceutical Industries, Inc.; 2020.
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Fusion Healthcare Pvt Ltd
Address: Fusion House, Plot No. 22, H.No 8-2-350/B, Road No. 3, Banjara Hills, Hyderabad, Telangana-500034

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Trespin 300mg Respules. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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