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Doliprane 125mg/5ml Syrup

Paracetamol (125mg/5ml)
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Doliprane 125mg/5ml Syrup is a widely prescribed medicine that helps to ease pain and bring down high body temperature (fever). In children, it treats conditions like headache, toothache, body ache, fever, and common cold.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 14 Apr 2026 | 04:20 PM (IST)
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Your child’s medicine at a glance

Doliprane 125mg/5ml Syrup is given orally preferably at a fixed time every day. Though this medicine can be taken before or after food, it is best given after food as it can irritate the inner lining of an empty stomach. The dose and duration will depend upon your child’s age, body weight, and severity of the infection, so stick to the dose, time, and way prescribed by your child’s doctor. If your child vomits within 30 minutes of taking the medicine, let the child calm down and repeat the same dose. Redosing is not recommended if your child gets sick more than 30 minutes after taking a dose.

Do not give your child Doliprane 125mg/5ml Syrup along with other medicines (many cold and flu medicines and other painkillers) that contain paracetamol, as this may result in overdosing and cause dangerous side effects such as hepatotoxicity (liver damage). Always check the ingredients of any other medicines before giving them to your child in combination with this medicine.

Generally, this medicine is well-tolerated by the children. However, temporary side effects such as nausea, and vomiting may occur in some children. Consult your doctor in case these episodes become bothersome for your child.

This medicine is often considered safe and effective but may not be suitable for everybody. Inform your doctor if your child is undergoing treatment for any blood-related disorder, is allergic to any medicinal compound, or has any birth defects, liver impairment, or kidney dysfunction. This will help your child’s doctor evaluate the dose and suitability of this medicine in a better way.

Uses of Doliprane 125mg/5ml Syrup in children

Benefits of Doliprane 125mg/5ml Syrup for your child

Pain relief
Doliprane 125mg/5ml Syrup is a common painkiller used to treat aches and pains. It works by blocking chemical messengers in the brain that tell us we have pain. It is effective in relieving pain caused by headache, migraine, nerve pain, toothache, sore throat, period (menstrual) pains, arthritis, and muscle aches. This medicine is very widely used and very rarely causes side effects if taken at the right dosage. Take it as it is prescribed to get the most benefit. Do not take more or for longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. It is also the first choice of painkiller during pregnancy or breastfeeding.
Treatment of Fever
Doliprane 125mg/5ml Syrup is also used to reduce a high temperature (fever). It works by blocking the release of certain chemical messengers that cause fever. It may be prescribed alone or in combination with another medicine. You should take it regularly as advised by your doctor.

Side effects of Doliprane 125mg/5ml Syrup in children

Doliprane 125mg/5ml Syrup does not pose serious side effects and is well-tolerated by children. In case the side effects do occur, they’re likely to subside once the body adapts to the medicine. Consult your child’s doctor if these side effects persist or bother your child. The most common side effects include-
Common side effects of Doliprane
  • Insomnia (difficulty in sleeping)
  • Nausea
  • Vomiting
  • Headache
  • Constipation
  • Itching

How can I give Doliprane 125mg/5ml Syrup to my child?

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Doliprane 125mg/5ml Syrup should be taken with or after food.

How Doliprane Syrup works

Doliprane 125mg/5ml Syrup possesses analgesic (pain-reliever) and antipyretic (lowers body temperature) properties. It provides relief by blocking certain chemical messengers and pathways in the brain that send signals about pain and fever.

Quick tips

  • Give Doliprane 125mg/5ml Syrup to your child with food or milk to prevent an upset stomach.
  • Your child should not take more than four doses of this medicine in 24 hours, so wait up to 6 hours between doses.
  • Never give any other medicine formulation containing paracetamol along with this medicine as that may lead to serious side effects.
  • Inform the doctor if your child has liver disease as the dose may need to be adjusted.
  • If Doliprane 125mg/5ml Syrup does not seem to be helping your child, contact your doctor for advice. Do not give extra doses.

Safety advice

Kidney

Kidney

CAUTION
Doliprane 125mg/5ml Syrup should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
However, Doliprane 125mg/5ml Syrup contains paracetamol which is considered the safest painkiller for children with kidney disease.
Liver

Liver

UNSAFE
Doliprane 125mg/5ml Syrup is unsafe to use in patients with liver disease and should be avoided.
However, the use of Doliprane 125mg/5ml Syrup is not recommended in children with severe liver disease and active liver disease.

Interaction with drugs

Taking Doliprane with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Imatinib mesylate (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Paracetamol may decrease the metabolism of Imatinib mesylate.
Moderate

Didanosine (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Your doctor may adjust the dose if required.
Moderate

Lenalidomide (Oral Route)

Your doctor may monitor your liver function frequently.
Moderate

Dicloxacillin (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Paracetamol may increase the effect of Dicloxacillin.
Moderate

Flucloxacillin Sodium (Injection Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your liver function. Paracetamol may reduce blood levels and/or fasten the elimination of Flucloxacillin Sodium.

Frequently asked questions

Always follow your doctor's instructions regarding how much of the medicine to give and how often to give it. This depends on the strength of the medicine and the age of your child. You may also check the label or the leaflet inside the packaging for directions before use. The commonly recommended dose is 10-15 mg/kg per dose every 4 to 6 hours. In case you are not sure how much to give, consult your child’s doctor.
Doliprane 125mg/5ml Syrup usually starts working within 30 to 60 mins of intake and shows its peak effect within 3 to 4 hours. Your child may start to feel better after a few doses. In case the pain or fever persists longer, consult your child’s doctor immediately.
If your child vomits within 30 minutes of taking Doliprane 125mg/5ml Syrup, repeat the dose again. If it has been more than 30 minutes after taking Doliprane 125mg/5ml Syrup and your child vomits, no need to repeat the dose and wait until it is time for the next dose. If you are not sure, consult your doctor.
You can give this medicine if your child has a temperature of 38.3°C (101°F) or higher. But, you must always try to speak to your child’s doctor first.
If the fever doesn't come down after the initial few doses, the cause might be an infection (virus or bacteria). It is advised to consult your child’s doctor for specific treatment.
You should only take four doses of Doliprane 125mg/5ml Syrup in 24 hours. There should be a gap of at least 4-6 hours between two doses. Do not take it for more than 3 days without first talking to your doctor. Based on the dose, more than 250 mg/kg can lead to toxicity and can be potentially fatal. An overdose is capable of causing serious damage to the liver and kidneys. Inform your doctor immediately if you think you have given too much of this medicine to your child, even if your child seems well, because of the risk of delayed, serious liver damage.
Unless instructed by your doctor, your child should take a normal balanced diet while continuing this medicine as lack of nutrition can put your child at risk of developing medicinal toxicity.
Keep this medicine at room temperature in a dry place beyond the reach of the children.
It is advised to use Doliprane 125mg/5ml Syrup with caution if the child has malnutrition, G6PD deficiency, liver disease, or any medicinal allergy. So, do not hesitate to share your child’s complete medical history with the doctor as that will help the doctor decide whether the medicine is safe for your child or not.
Doliprane 125mg/5ml Syrup usually do not interfere with the ingredients in vaccines or cause a bad reaction in a child who has just been vaccinated. However, it is best if you let your child recover from the ongoing illness and finish the course of the medicine As soon as a child is feeling better the vaccine can and should be given.
If you vomit in less than 30 minutes after having a dose of Doliprane 125mg/5ml Syrup tablets or syrup, retake the same dose again. If you vomit after 30 minutes of a dose, you do not need to take another one until the next standard dose.
Usually, you will start feeling better after about half an hour of taking a Doliprane 125mg/5ml Syrup.
You should only take four doses of Doliprane 125mg/5ml Syrup in 24 hours. There should be a gap of at least 4 hours between two doses. Do not take Doliprane 125mg/5ml Syrup for more than 3 days without consulting a doctor first.
No, Doliprane 125mg/5ml Syrup does not make babies sleepy. It is a pain-relieving medicine that is also used to control high fever.
Doliprane 125mg/5ml Syrup is considered safe for children only when used as directed by the doctor.
No, Doliprane 125mg/5ml Syrup is not an antibiotic. It works as a painkiller and fever-reducing medicine.
Ibuprofen and Doliprane 125mg/5ml Syrup are safe medicines, but both should not be used together. Consult your doctor if you are not sure.
Doliprane 125mg/5ml Syrup takes around 30-45 min to start working and show its effects. It is advised to take this medicine for the duration suggested by the doctor. Consult your doctor if you experience any bothersome side effects.
Overdose of Doliprane 125mg/5ml Syrupe may cause severe life-threatening liver injury. Taking more than the prescribed dose may also cause kidney injury, decreased platelet count, and even coma. Early symptoms of an overdose include nausea, vomiting, and general tiredness. Immediately consult a doctor or reach an emergency in case of a suspected overdose.

Fact Box

Chemical Class

1- hydroxy- 2- unsubstituted benzenoids

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

Action Class

Analgesic & Antipyretic-PCM

Related lab tests

References

  1. Children’s Health Queensland Hospital and Health Service. Emergency care of children: Medication guides for use in Queensland. [Accessed 26 Dec. 2020] (online) Available from:
  2. Royal College of Paediatrics and Child Health. Medicines for Children - information for parents and carers. [Accessed 26 Dec. 2020] (online) Available from:
  3. Aabideen K, Moulton LS, Sills J. Accidental staggered paracetamol overdose: An interesting case report. J Pharmacol Pharmacother. 2011;2(3):189-190. [Accessed 26 Dec. 2020] (online) Available from:
  4. Paracetamol [EMC Patient Leaflet]. Leeds, UK: Rosemont Pharmaceuticals Limited; 2019. [Accessed 26 Dec. 2020] (online) Available from:
  5. Grosser T, Smyth E, FitzGerald G. Pharmacotherapy of Inflammation, Fever, Pain, and Gout. In: Brunton LL, Hilal-Dandan R, Knollmann BC (Editors). Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 13th ed. New York, New York: McGraw-Hill Medical; 2018.
  6. Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 982-84.
  7. Acetaminophen [Prescribing Information]. lake Zurich, IL: Fresenius Kabi USA, LLC; 2015. [Accessed 25 Jul. 2024] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Abbott
Address: 16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Doliprane 125mg/5ml Syrup. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

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