Information about Lenalidomide

Lenalidomide Uses

Lenalidomide is used in the treatment of multiple myeloma and lepra reaction.

How Lenalidomide works

Lenalidomide is an anti-cancer medication. It works by enhancing the immune system that indirectly attacks the cancer cells. It prevents the growth of new blood vessels within the tumor. It also restricts the production of chemical messengers (cytokine and growth factor) which are responsible for the growth of cancer cells. This is how it works against cancer.

Common side effects of Lenalidomide

Headache, Nausea, Rash, Breathlessness, Dizziness, Fatigue, Decreased white blood cell count (neutrophils), Joint pain, Insomnia (difficulty in sleeping), Itching, Diarrhea, Depression, High blood pressure, Low blood platelets, Lymphocytopenia, Autoimmune hemolytic anemia, Peripheral edema, Cough, Back pain, Upper respiratory tract infection, Urinary tract infection, Decreased appetite, Decreased potassium level in blood, Increased alanine aminotransferase, Increased aspartate aminotransferase, Discomfort when urinating, Palpitations, Leukemia (blood cancer), Decreased level of thyroid hormones, Bruise, Fall, Pneumonia, Increased glucose level in blood, Taste change, Nasopharyngitis (inflammation of the throat and nasal passages)
Written By
PhD (Pharmacology), PGDPRA
Reviewed By
MD Pharmacology, MBBS
Last updated
25 Apr 2023 | 05:43 PM (UTC)

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Available Medicine for Lenalidomide

LenalidNatco Pharma Ltd
2196 to ₹92965 variant(s)
LenangioDr Reddy's Laboratories Ltd
632 to ₹27596 variant(s)
LenzestSun Pharmaceutical Industries Ltd
28881 variant(s)
LenmidCipla Ltd
1098 to ₹27962 variant(s)
LenomeIntas Pharmaceuticals Ltd
671 to ₹29196 variant(s)
LenomustPanacea Biotec Pharma Ltd
87001 variant(s)
LenidUnited Biotech Pvt Ltd
29001 variant(s)
MyelosafeS R Pharmaceuticals
981 variant(s)
LendomyMylan Pharmaceuticals Pvt Ltd - A Viatris Company
1887 to ₹77003 variant(s)

Expert advice for Lenalidomide

  • You may be monitored with regular blood tests before and during the treatment as lenalidomide may cause a fall in the white blood cells and platelets, required to fight infection, Hemoglobin and blood clotting.
  • Avoid activities that may cause bruising or injury and avoid contact with people who have colds or infections.
  • It makes your skin sensitive towards sunlight. Apply sunscreen or wear protective while going out. 
  • It may cause dehydration. Drink plenty of water to stay hydrated while taking medication.
  •  It is not recommended for use in children and adolescents under 18 years.
  • You should use proper contraceptive methods at least 4 weeks before, during and until 4 weeks after stopping treatment. 
  • Woman of childbearing potential will be required to undergo pregnancy tests before and after the treatment.
  • You should inform your doctor or dentist that you are taking Lenalidomide before you receive any medical or dental care, emergency care, or surgery.
  • It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
  • You may be at risk of developing acute myelogenous leukemia, Hodgkin lymphoma tumor lysis syndrome, fatal liver problems, severe skin reactions, and fatal heart problems during treatment with Lenalidomide. You should discuss in advance the benefits and risks of taking this medicine. 

Frequently asked questions for Lenalidomide


Q. Can I take Lenalidomide empty stomach?

Lenalidomide may be taken with or without food. Always take it exactly as prescribed by your doctor. Do not crush, cut or chew the capsules. Swallow it whole with water. You should take Lenalidomide at about the same time on the scheduled days.

Q. Can Lenalidomide be given to patients who are on dialysis?

Yes, Lenalidomide is given to dialysis patients after the dialysis is done. However, the doctor may adjust the dose if needed in patients undergoing.

Q. What are the side effects of Lenalidomide?

Lenalidomide may cause side effects which include diarrhea, constipation, stomach pain, loss of appetite, weight loss, weakness, dizziness, change in ability to taste, and pain or burning of the tongue, mouth, or throat. The medicine may also cause decreased sense of touch, burning or tingling in the hands or feet, difficulty falling asleep or staying asleep, depression, and joint, muscle, bone, or back pain. You may also experience sweating, dry skin, abnormal hair growth in women, uncontrollable shaking of a part of the body, decrease in sexual desire or ability or painful, frequent, or urgent urination. Tell your doctor if any of these symptoms are severe or do not go away.

Q. What are the serious side effects of Lenalidomide?

The serious side effects of Lenalidomide include difficult breathing or swallowing, hoarseness or swelling of the face, throat, tongue, lips, eyes, arms, hands, feet, ankles, or lower legs. Some of the serious side effects may also include seizures, rash, skin pain, fast, slow, pounding, or irregular heartbeat or blistering, peeling, or shedding skin. It may also cause swollen glands in the neck, muscle cramps, pain in the upper right part of the stomach, yellowing of the skin or eyes, dark colored urine, tiredness, or bloody, cloudy, or painful urination and increased or decreased urination. Call your doctor immediately if you get any of these side effects.

Q. Can Lenalidomide cause cancer?

People with multiple myeloma (a form of cancer that begins in plasma cells, a type of white blood cell) who receive melphalan (chemotherapy) and a blood stem cell transplant with the addition of Lenalidomide have a higher risk of developing new cancers. These types of cancers may include certain blood cancers (acute myelogenous leukemia or AML) and a type of lymphoma called Hodgkin lymphoma. Talk to your doctor about your risk of developing new cancers if you are taking Lenalidomide.

Q. Do I need to get any blood tests done while on Lenalidomide?

Your doctor will ask you to have a blood test before treatment and every week for the first 8 weeks of treatment. You may need to continue taking the blood tests at least every month after treatment with Lenalidomide ends. Frequent blood tests are important as Lenalidomide may decrease the blood cells that help fight infection (white blood cells) and help the blood to clot (platelets).

Q. Do I need to use birth control methods while using Lenalidomide?

Women who can become pregnant must use two acceptable forms of birth control for 4 weeks before they begin taking Lenalidomide. Continue using contraceptives during your treatment, including the times when your doctor tells you to temporarily stop taking Lenalidomide, and for 4 weeks after your final dose. In men, Lenalidomide may pass into the semen while they are on treatment. Therefore, men must always use a latex condom every time they have sexual contact, even if they have had a vasectomy (surgery that prevents a man from causing a pregnancy). Use the contraceptive while you are taking Lenalidomide, during any breaks in your treatment, and for 4 weeks after your final dose.


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