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Dicloxacillin is used to treat bacterial infections of the bone, ear, skin and soft tissue, urinary tract infections, sinus infection, lung infections upper respiratory tract infection, and infection of bones .

How it works

Dicloxacillin belongs to class of medications called penicillin antibiotics. Dicloxacillin causes bacterial cell death by interfering with formation of the bacterial cell wall.

Common side effects

Nausea, Shortness of breath, Skin rash, Stomach upset, Sunburn, Photosensitivity, Itching, Urticaria, Vaginal infection, Vomiting, Wheezing, Constipation, Diarrhoea


Expert advice

  • Take dicloxacillin by mouth either 1 hour before or 2 hours after eating.
  • Mild diarrhea is common with the use of dicloxacillin however if stomach pain or cramps, severe diarrhea, or bloody stools occur call your doctor.
  • Birth control pills may not work as well when you are taking dicloxacillin; use a secondary birth control measure. Consult your doctor for the same. 

Frequently asked questions


Q. Is dicloxacillin a penicillin, tetracycline or a broad spectrum antibiotic?
Dicloxacillin belongs to class of medicines called penicillin antibiotics. Dicloxacillin is not a tetracycline or a broad spectrum antibiotic.

Q. Does it contain sulfa?
 It does not contain sulfa.
Q. Is dicloxacillin used to treat sexually transmitted disease, strep throat, and methicillin resistant Staphylococcus aureus (MRSA)?
Dicloxacillin can be used to treat strep throat. It is not approved to treat sexually transmitted diseases and is not active against MRSA.
Q. Is dicloxacillin the same as amoxicillin?
Dicloxacillin and amoxicillin belongs to same category of drugs with similar action, dicloxacillin is resistant to beta-lactamase producing organism, while amoxicillin is susceptible to degradation by beta-lactamase producing organism.
Q. Can I take dicloxacillin with Tylenol, Advil, Benadryl, and Tums?
Dicloxacillin can be taken with Tylenol, Benadryl and Tums. Dicloxacillin when taken with Advil (ibuprofen) may increase the effects of either dicloxacillin or ibuprofen.
Q. Does dicloxacillin decrease milk supply?
Generally, dicloxacillin does not decrease milk secretion.

Q. Does dicloxacillin cause heartburn?
 It may cause heartburn.

Content on this page was last updated on 14 October, 2016, by Dr. Varun Gupta (MD Pharmacology)