



Depo-Provera Injection
Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)

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General Information





Product introduction
Depo-Provera Injection is administered only by or under the supervision of doctor. It should be taken as your doctor advice. Your doctor will decide how much you need to take and for how much time. You should take this injection for as long as it is prescribed for you.
The most common side effects of this medicine include headache, dizziness, abdominal pain, nervousness, weight gain, and breast tenderness. If any of these bothers you, let your doctor know. There may be ways of reducing or preventing them. It may also cause irregular menstrual cycle, spotting or your menstrual bleeds to stop altogether. Inform your doctor if you get heavy or prolonged bleeding.
Before taking this medicine, you must let your doctor know if you ever had any problems like history of blood clots, stroke, heart attack, liver, or bleeding problems. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. You must not take it if you are pregnant.
Uses of Depo-Provera Injection
Benefits of Depo-Provera Injection
Depo-Provera Injection is a synthetic progestin that replicates the effect of a natural female hormone called progesterone. It slows the growth of the lining of the womb before menstruation, which reduces the bleeding during menstruation. If heavy periods become such a problem that they interfere with your everyday life, then try taking things a little easier on those days. Some women find that relaxation techniques or yoga help them feel more relaxed and reduce stress. Getting a lot of exercise can also help.
Depo-Provera Injection contains progesterone, a female hormone that is important in the regulation of ovulation and menstruation. It is used to cause menstrual periods in women who have not reached menopause but are not having periods due to a lack of natural progesterone in the body. You should use the medicine as prescribed for it to be effective. Avoid any stress and follow your doctor’s instructions carefully. Improving weight and nutrition may be recommended in females with eating disorders or malnutrition to get the maximum benefit from Depo-Provera Injection.
Side effects of Depo-Provera Injection
- Weight gain
- Breast tenderness
- Headache
- Abdominal pain
- Weakness
- Dizziness
- Irregular menstrual cycle
- Nervousness
How to use Depo-Provera Injection
How Depo-Provera Injection works
Quick tips
- Depo-Provera Injection is used for preventing pregnancy (contraception).
- To avoid the risk of becoming pregnant you must take the injection once after every 12 weeks.
- It is usually given into the muscle of the buttock or upper arm.
- The injection cannot be reversed once it has been given and its effects last for at least 12 weeks.
- Fertility does return once the injections are stopped, but the time varies for each woman.
- It may cause irregular bleeding, spotting or your menstrual bleeds to stop altogether. Inform your doctor if you get heavy or prolonged bleeding.
- Long term use can cause a loss of bone mineral density and increase the risk of weak bones and osteoporosis.
- Do not take Depo-Provera Injection if you're pregnant or breastfeeding, or have a history of blood clots, stroke, heart attack, liver problems, or bleeding problems.
Safety advice

Alcohol

Pregnancy

Breast feeding
Nonhormonal contraceptives are preferred in breastfeeding women, especially during the first 4 weeks postpartum

Driving

Kidney

Liver
Interaction with drugs
Letrozole (Oral Route)
Mycophenolate mofetil (Oral Route)
Lorlatinib (Oral Route)
Ursodeoxycholic Acid (Oral Route)
Gliclazide (Oral Route)
Frequently asked questions
Fact Box
Chemical Class
Habit Forming
Therapeutic Class
Action Class
Related lab tests
References
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 850-54.
- Medroxyprogesterone acetate. Pfizer: Puurs, Belgium: 2018. [Accessed 21 Jan. 2019] (online) Available from:
- Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 03 Apr. 2019] (online) Available from:
- Medroxyprogesterone Acetate injectable suspension [Drug Label]. Kalamazoo, MI: Pharmacia & Upjohn Company; 2022. [Accessed 25 Jul. 2024] (online) Available from:




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Marketer details
Address: The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.
Vendor Details
A licensed vendor partner from your nearest location will deliver Depo-Provera Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)














