
NSE (Neuron Specific Enolase), Serum









The NSE (Neuron Specific Enolase), Serum test is a blood test that measures the level of neuron-specific enolase (NSE), an enzyme found mainly in nerve cells and neuroendocrine cells. This test helps in the detection, diagnosis, and monitoring of certain cancers, particularly small cell lung cancer and neuroblastoma, and may also be used to assess brain injury.













Understanding NSE (Neuron Specific Enolase), Serum
Neuron-specific enolase (NSE) is a protein enzyme involved in energy metabolism, normally found in nerve cells and neuroendocrine tissues. Under normal conditions, only very small amounts of NSE circulate in the blood. Elevated levels, however, can indicate nerve cell damage or abnormal growth of neuroendocrine tumors.
The NSE (Neuron Specific Enolase), Serum test measures the level of NSE in the blood and is primarily used as a tumor marker for small cell lung cancer and neuroblastoma, a type of cancer that arises in immature nerve cells and predominantly affects infants and children. Doctors may also advise this test to monitor treatment response or to check for cancer recurrence. In addition to its role in cancer detection, the NSE test may be performed alongside other diagnostic tests to evaluate other neuroendocrine tumors, certain brain disorders, or severe bodily injury or trauma, as damaged neurons and neuroendocrine cells release NSE into the blood.
It is important to note that while high NSE levels may indicate one of these cancers, brain injuries, or neuroendocrine conditions, the test alone cannot confirm a diagnosis, and further tests are needed for confirmation.
No special preparation is needed for getting the NSE (Neuron Specific Enolase), Serum test done. However, be sure to inform the doctor about any medications or supplements being taken, as they may affect the test results.
Lab test results may vary across different laboratories. Abnormal test results require expert interpretation. Therefore, never try to self-medicate based solely on these results. Always consult a doctor for a proper understanding of the test results.
Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.
What does NSE (Neuron Specific Enolase), Serum measure?
The NSE (Neuron Specific Enolase), Serum test measures the level of neuron-specific enolase (NSE) in the blood, an enzyme primarily found in nerve cells and neuroendocrine tissues that plays a key role in energy metabolism. When these cells are damaged, injured, or grow abnormally, as in cancers such as small cell lung cancer, neuroblastoma, medullary thyroid carcinoma, or carcinoid tumors, they release excess NSE into the blood. Elevated NSE levels may also occur in brain injury, stroke, or other neurological conditions. Normal or low NSE levels are generally not a cause for concern, but must still be interpreted alongside clinical findings and other diagnostic tests. NSE is not entirely specific; it may rise in some non-cancerous conditions as well, so doctors typically use this test in combination with imaging studies and other tumor markers to arrive at an accurate diagnosis.





FAQs related to NSE (Neuron Specific Enolase), Serum
- Isgrò MA, Bottoni P, Scatena R. Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects. Adv Exp Med Biol. 2015;867:125-43. [Accessed 27 Sep. 2025]. Available from:
- Neuron Specific Enolase [Internet]. ScienceDirect; [Accessed 27 Sep. 2025]. Available from:
- Babkina AS, Lyubomudrov MA, Golubev MA, Pisarev MV, Golubev AM. Neuron-Specific Enolase-What Are We Measuring? Int J Mol Sci. 2024 May 6;25(9):5040. [Accessed 27 Sep. 2025]. Available from:
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