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Lactate Dehydrogenase, Serum

Also known as Lactic Dehydrogenase, Lactic Acid Dehydrogenase
329400 17% Off
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation is required.

Understanding Lactate Dehydrogenase, Serum


What is Lactate Dehydrogenase, Serum?

The Lactate Dehydrogenase, Serum test measures the amount of lactate dehydrogenase (LDH) enzyme in the blood. This enzyme is found in nearly all of the body’s cells, with the highest levels in the cells of the heart, liver, muscles, red blood cells and kidneys. It is released in the bloodstream as a result of tissue damage following an injury. This test can help detect a variety of conditions, including heart disease, liver disease, muscle injury, and certain types of cancer.

The lactate dehydrogenase (LDH) enzyme plays a crucial role in the process of converting lactate into pyruvate (a type of sugar), which is then used by the cells for energy. Under normal circumstances, it exists at low levels in the blood. However, during severe tissue damage, LDH levels rise significantly, serving as a valuable biomarker for the diagnosis of tissue damage. The Lactate Dehydrogenase, Serum test measures the level of LDH enzyme that can indicate tissue damage or disease processes affecting different organs in the body. However, this test does not give clues about the location of the damage.

Your doctor may recommend this test if you experience symptoms such as fatigue, muscle weakness, chest pain or discomfort, breath shortness, unexplained weight loss, fever, etc, suggestive of tissue damage. Additionally, the Lactate Dehydrogenase, Serum test may also be used to monitor the progression of certain diseases and conditions and evaluate the effectiveness of ongoing treatment.

Higher than normal LDH levels can be seen in various conditions such as muscle injury, liver disease, and heart attacks, and the test is not specific to a single disease or organ system. Hence, additional tests such as imaging studies, other blood tests, or tissue biopsies may be necessary to determine the exact cause of increased LDH levels and confirm a diagnosis.

Usually, no special preparation is needed before undergoing the Lactate Dehydrogenase, Serum test. However, it is important to tell your doctor about any medications and supplements you take, as certain medications can affect your test results. Additionally, it is advised to avoid any strenuous exercise or alcohol consumption a few hours before the test, as these factors can interfere with the test results.

Reference ranges are approximate and may vary based on factors such as age, gender, medical history, etc. Abnormal test results require an expert interpretation; therefore, always consult a doctor for a proper understanding of the test results.

 

What is Lactate Dehydrogenase, Serum used for?

The Lactate Dehydrogenase, Serum test is done: 

  • To detect and monitor the progress of tissue damage in the body.
  • To detect heart disease, including heart attacks.
  • To detect liver diseases including hepatitis or cirrhosis.
  • To detect muscle disorders including muscular dystrophy or severe muscle trauma.
  • To detect blood disorders including anemia and hemolytic anemia.
  • To assess the severity of certain cancers including lymphoma and leukemia.
  • To monitor chemotherapy for certain types of cancer to see if treatment is working.

What does Lactate Dehydrogenase, Serum measure?

The Lactate Dehydrogenase, Serum test measures the level of the enzyme lactate dehydrogenase (LDH) in the blood. LDH is involved in energy production and is present in many types of cells, including those in the heart, liver, muscles, kidneys, brain, and blood cells. When these cells are damaged or destroyed, they release LDH into the bloodstream. Therefore, a minor amount of LDH is continuously released into the bloodstream as part of regular cell turnover and metabolic processes. However, elevated LDH is concerning because it usually signals underlying tissue damage, inflammation, or a wide range of diseases such as liver disease, heart disease, hemolytic anemia, and certain cancers. Its elevation necessitates further diagnostic evaluation to determine the specific cause and appropriate treatment.

Interpreting Lactate Dehydrogenase, Serum results


Interpretations

Normal range (Approx.):

·         Newborns: 160 to 450 units/L

·         Infants: 100 to 250 units/L

·         Child: 60 to 170 units/L

·         Adult/elderly adult: 100 to 190 units/L

Higher than normal levels of lactate dehydrogenase indicates the presence of conditions causing damage to the body tissues. Further tests are performed to determine the exact location and extent of the condition.

 

 

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Lactate Dehydrogenase, Serum


Frequently Asked Questions about Lactate Dehydrogenase, Serum

Q. What is the Lactate Dehydrogenase, Serum test?

The Lactate Dehydrogenase, Serum is a blood test that measures the levels of the enzyme lactate dehydrogenase in the blood. Elevated LDH levels can indicate tissue damage or disease.

Q. Why is the lactate dehydrogenase test done?

The lactate dehydrogenase (LDH) test is done to monitor conditions associated with tissue damage, such as heart disease, liver disorders, muscle injury, anemia, and certain cancers.

Q. How is the LDH test performed?

A phlebotomist (a trained professional to perform blood draws) will clean your skin using an antiseptic alcohol cotton swab or wipe and take blood samples from your vein using a needle. The blood sample will be stored safely and transported to the laboratory for analysis.

Q. Do I need to fast before taking the LDH test?

No fasting is required for this test. You can schedule it at your convenience without avoiding food or water beforehand.

Q. How often should I get tested?

The frequency of testing will depend on your doctor's advice based on your symptoms and risk factors.

Q. What do high levels of lactate dehydrogenase indicate?

High levels of LDH in the serum can indicate cell damage due to various causes, including heart attack, hemolysis, liver disease, muscle injury, or cancer. However, LDH is not specific to any one condition.

Q. What should I do if my LDH levels are abnormal?

If your LDH levels are abnormal, it's essential to follow up with your doctor for further evaluation and appropriate management. Your doctor will help interpret the results in the context of your overall health and symptoms.

Q. Are low levels of LDH significant?

Low levels of LDH are generally not considered clinically significant. However, in rare cases, lowered levels may be associated with genetic mutations affecting the LDH enzyme.
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Lactate Dehydrogenase, Serum test price for other cities


Price inBangaloreRs. 329
Price inMumbaiRs. 329
Price inKolkataRs. 329
Price inGurgaonRs. 329
Price inPuneRs. 329
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References

  1. Lactate Dehydrogenase (Blood) [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 21 May. 2024]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=lactic_acid_dehydrogenase_blood External Link
  2. Lactate dehydrogenase (LDH) test [Internet]. NHS; 28 Mar. 2022 [Accessed 21 May 2024]. Available from: https://www.nhs.uk/conditions/ldh-test/ External Link
  3. Farhana A, Lappin SL. Biochemistry, Lactate Dehydrogenase. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557536/ External Link
  4. Kim J, Kim YW, Kim TY. Diagnostic Value of Serum Lactate Dehydrogenase Level Measured in the Emergency Department in Predicting Clinical Outcome in Out-of-Hospital Cardiac Arrest: A Multicenter, Observational Study. J Clin Med. 2023 Apr 20;12(8):3006. [Accessed 21 May. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146741/ External Link
  5. Lin L, Gao R, Chen L, Wu Z, Wei X, Xie Y. Relationship between serum lactate dehydrogenase and mortality after cardiac arrest: A retrospective cohort study. Medicine (Baltimore). 2022 Nov 11;101(45):e31499. [Accessed 21 May. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666175/ External Link
  6. Nand N, Sharma M, Saini DS. Evaluation of lactic dehydrogenase in cases of meningitis. Indian J Med Sci. 1993 Apr;47(4):96-100. PMID: 8354546. [Accessed 21 May. 2024]. Available from: https://pubmed.ncbi.nlm.nih.gov/8354546/ External Link
  7. Feng Y, Xiong Y, Qiao T, Li X, Jia L, Han Y. Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy. Cancer Med. 2018 Dec;7(12):6124-6136. [Accessed 21 May. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308051/ External Link
  8. Kotoh K, Kato M, Kohjima M, Tanaka M, Miyazaki M, Nakamura K, Enjoji M, Nakamuta M, Takayanagi R. Lactate dehydrogenase production in hepatocytes is increased at an early stage of acute liver failure. Exp Ther Med. 2011 Mar;2(2):195-199. [Accessed 21 May. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440653/ External Link
  9. Kato GJ, McGowan V, Machado RF, Little JA, Taylor J 6th, Morris CR, Nichols JS, Wang X, Poljakovic M, Morris SM Jr, Gladwin MT. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood. 2006 Mar 15;107(6):2279-85. [Accessed 21 May. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895723/ External Link

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