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IGF-1 (Somatomedin C)

Also referred as

Somatomedin C

Insulin-like Growth Factor - 1

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The IGF-1 (Somatomedin C) test is a blood test that measures the levels of insulin-like growth factor-1 (IGF-1) hormone and how active growth hormone (GH) is. It helps evaluate growth disorders such as growth hormone deficiency, acromegaly, gigantism, Laron syndrome, etc., in both children and adults.

Samples required

Blood

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Preparations

Overnight fasting required for 8 to 12 hours

Sample Collection

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Understanding IGF-1 (Somatomedin C)

IGF-1, also called somatomedin C, is structurally similar to insulin and plays an important role in bone and tissue growth. This hormone is produced primarily in the liver in response to growth hormone (GH) stimulation. Unlike GH, which fluctuates throughout the day, IGF-1 levels remain stable, making it a reliable marker for evaluating the overall functioning of the GH activity.

The IGF-1 (Somatomedin C) test is advised when a child has growth and development abnormalities such as short stature or slow/delayed growth. Also, it is to be considered when an adult has reduced bone density and muscle mass and increased levels of lipids, it may be linked to insufficient GH and IGF-1 production. Moreover, the IGF-1 (Somatomedin C) test is recommended when there are signs and symptoms of gigantism in children or acromegaly in adults; when there is a suspicion of a pituitary disorder; or during and after treatment for GH disorders. Furthermore, the IGF-1 (Somatomedin C) test is suggested along with other hormone tests for a comprehensive assessment.

Overnight fasting of 8-12 hours is required before the test. However, drinking water is permissible. Inform a doctor about any medications or supplements taken, as some (like estrogen or high-dose steroids) can affect IGF-1 levels.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate, and always consult a doctor to understand the test results correctly. These results help determine whether growth, hormone levels, and metabolism are functioning normally.

Please note: This is an outsourced test. The sample is collected by TATA 1MG and processed at a NABL accredited partnered lab.

What does IGF-1 (Somatomedin C) measure?

The IGF-1 (Somatomedin C) test measures the levels of insulin-like growth factor-1 (IGF-1) in the blood. This hormone plays an important role in growth and development in both children and adults. Doctors use the IGF-1 (Somatomedin C) test to support the diagnosis of and monitor growth disorders (like dwarfism or gigantism in children, and acromegaly in adults), assess pituitary function, and check for nutritional deficiencies or IGF-1 levels affected by chronic liver or kidney conditions.

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FAQs related to IGF-1 (Somatomedin C)

Why is the IGF-1 (Somatomedin C) test needed?

The IGF-1 (Somatomedin C) test helps diagnose growth disorders such as dwarfism or gigantism in children and acromegaly in adults, evaluate pituitary gland function, monitor growth hormone (GH) therapy, and assess nutritional status as well as chronic diseases affecting the liver or kidneys.

Is fasting required before the test?

Yes, overnight fasting of 8 to 12 hours is advised for more precise results.

How is the test performed?

The test is done by taking a blood sample from a vein in the arm. The sample is then analyzed for the levels of IGF-1 in the lab.

Are there any risks associated with the IGF-1 (Somatomedin C) test?

No, the IGF-1 (Somatomedin C) test is generally safe with minimal risks. There may be slight discomfort, bruising, or swelling at the blood draw site, which resolves on its own and is not bothersome.

What do abnormal test results mean?

A. High levels: Indicates excess growth hormone (acromegaly/gigantism) or may be seen in a pituitary tumor. B. Low levels: Indicate growth hormone deficiency, malnutrition, liver disease, or hypopituitarism.

Can lifestyle affect IGF-1 levels?

Lifestyle factors such as poor nutrition, excessive alcohol consumption, intense exercise, or chronic stress can alter IGF-1 levels. Maintaining a healthy diet and making healthy lifestyle choices can affect IGF-1 levels.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

Dr. Swati Gupta (Anand)

MBBS, MD Lab Medicine

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Last Updated

4th Jan 2026