Desmoglein III Antibody (Vesiculobullous disorders)

Desmoglein III is an adhesion protein that maintains the structural integrity of mucous membranes and deeper skin layers. In autoimmune blistering conditions like pemphigus vulgaris, the immune system mistakenly produces autoantibodies against desmoglein III, breaking down cell-to-cell adhesion and causing fragile blisters and erosions.

The Desmoglein III Antibody (Vesiculobullous disorders) test is primarily used to confirm pemphigus vulgaris, particularly when blisters and erosions affect the mouth, throat, esophagus, or skin. It also helps distinguish pemphigus vulgaris from pemphigus foliaceus, which is associated with desmoglein I antibodies. Doctors may recommend this test if you are suspected of having an autoimmune blistering disorder or if you already have a confirmed diagnosis of pemphigus and require monitoring of disease activity and treatment response. Additionally, it aids in differentiating between subtypes of pemphigus and other vesiculobullous disorders, allowing for accurate diagnosis and effective management.

No special preparation is required for this test. You can eat and drink as per your routine. Inform your doctor about all the medications and supplements that you are currently taking, as these may affect the test results.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. 

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.