Test Detail
Overview
Interpreting Results

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Written by
Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
Reviewed by
Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Anti ds-DNA Antibody, EIA

(EIA)
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. Overnight fasting is preferred but not mandatory.

Overview


What is EIA?

Anti ds-DNA Antibody test is used for detection of SLE (Systemic Lupus Erythematosus). Anti ds-DNA are a type of antinuclear antibodies (ANA) which attack the DNA of the cells. In case of patients having a positive ANA test, it is always advisable to undergo this test. As this test specifically differentiate between lupus or any other type of autoimmune disorder. Typical symptoms of lupus include muscles pain, joints pain, butterfly shaped rashes, mild fever and numbness.

A positive test needs an immediate medical intervention. If ignored it can lead to multiple organ damage.

Why is EIA done?

  1. If you have signs or symptoms which might suggest systemic lupus erythematosus (SLE) along with a positive ANA test. Various signs and symptoms of lupus are: low grade fever, bone or joint pains, muscle pains, skin rashes, sensitivity to light, hair and weight loss 
  2. It may also be ordered to monitor the progress of the disease or flare ups in a person who has already been diagnosed with lupus

Interpreting EIA results


Interpretations

  • A high level of anti ds DNA antibody is strongly associated with lupus and is significantly increased during or just prior to a flare up. Therefore, when the ds DNA antibody test is positive and the person tested has other signs and symptoms associated with lupus, it means that the person likely has lupus 
  • Low to moderate levels of antibody may be seen with other autoimmune diseases like Sjogren syndrome 
  • A very low level of anti ds DNA is considered negative but does not exclude a diagnosis of lupus. Only 50-70% patients of lupus will have anti ds DNA

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