
Ceruloplasmin










The Ceruloplasmin test is a blood test that measures the level of ceruloplasmin, a copper-binding protein. This test is done to evaluate copper metabolism in the body. It helps diagnose conditions like Wilson’s disease, a genetic disorder that can lead to excess storage of copper in the eyes, liver, brain, and other organs.













Understanding Ceruloplasmin
Ceruloplasmin is a protein produced by the liver that helps transport and store copper through the blood. About 65% to 90% of the copper in the blood is carried by ceruloplasmin. Copper is important for many body functions, like building strong bones and making skin pigment (melanin).
Normally, the liver extracts copper from the blood and binds it to the ceruloplasmin protein. The ceruloplasmin is then released into the blood, transporting copper to various body parts. The Ceruloplasmin test provides important insights into how the body stores and uses copper.
The Ceruloplasmin test may be recommended if there are symptoms such as fatigue, jaundice, tremors, difficulty speaking or swallowing, changes in behavior, or signs of liver dysfunction. Doctors also use this test to diagnose conditions that can result in copper deficiency. These conditions may include malnutrition (lack of copper in the diet), malabsorption (inefficient absorption of copper in the digestive tract), too much dietary zinc (competes with copper for absorption), and Menkes disease (a genetic disease affecting copper absorption). This test is also done if there is a family history of Wilson's disease.
Usually, overnight fasting is preferred for getting tested. It is important to inform the doctor of any medications, supplements, or hormonal therapies being taken, as these can influence results.
Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate and always consult a doctor to understand the test results correctly.
Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.
What does Ceruloplasmin measure?
The Ceruloplasmin test measures the amount of ceruloplasmin (a copper transport protein) in the blood. As the primary copper-carrying protein, ceruloplasmin reflects how the body manages copper balance. Lower-than-normal levels can indicate problems with copper transport or metabolism. It is often seen in Wilson's disease or severe liver dysfunction.
Decreased ceruloplasmin levels may also occur in conditions like Wilson’s disease, Menke's disease, malnutrition, and chronic liver disease. Higher-than-normal levels may occur in inflammatory states, pregnancy, or with the use of birth control pills.





FAQs related to Ceruloplasmin
- Total Copper (Blood) [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 27 May 2025]. Available from:
- Lopez MJ, Royer A, Shah NJ. Biochemistry, Ceruloplasmin. [Updated 2023 Feb 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from:
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