Centromere Antibody

Centromere antibodies are a type of antinuclear antibody (ANA) that targets specific proteins in the centromere region of chromosomes. These antibodies are most commonly found in patients with autoimmune connective tissue diseases, especially limited systemic sclerosis (CREST syndrome), which can cause skin thickening, Raynaud’s phenomenon, and involvement of internal organs. Detecting centromere antibodies aids clinicians in diagnosing these disorders early and differentiating them from other autoimmune or rheumatologic conditions.

The Centromere Antibody test is recommended for individuals showing signs and symptoms suggestive of systemic sclerosis or related autoimmune conditions, such as skin thickening, Raynaud’s phenomenon (discoloration of fingers and toes in response to cold or stress), fingertip ulcers, joint stiffness, or unexplained fatigue. It is particularly useful in confirming systemic sclerosis and differentiating it from other autoimmune diseases. The test may also be advised for patients already diagnosed with systemic sclerosis to monitor disease activity and assess the effectiveness of treatment. Additionally, it is considered for those with a family history of autoimmune connective tissue disorders, as they may be at a higher risk of developing these conditions.

Overnight fasting is preferred for this test, but it is not mandatory. However, it is preferred that you share your clinical history, current medications, and supplement use with your doctor before giving the sample, as these may influence the results.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate, and always consult a doctor to understand the test results correctly. 

Please note: This is an outsourced test. The sample is collected by TATA 1MG and processed at a NABL accredited partnered lab.