Scl-70 Antibody

SCL-70, also known as DNA topoisomerase I, is an enzyme found in the cell nucleus that helps unwind DNA during replication and transcription. In certain autoimmune conditions, the immune system mistakenly produces antibodies against this enzyme. The presence of SCL-70 antibodies in the blood suggests abnormal immune activity and is considered a significant marker for systemic sclerosis (scleroderma).

SCL-70 antibodies are strongly associated with diffuse cutaneous systemic sclerosis, a severe form of scleroderma that can affect the skin, lungs, kidneys, and other internal organs. However, these antibodies are not exclusive and may appear in overlap syndromes. 

This test supports the diagnosis when combined with clinical findings and other tests and assesses the risk of complications, especially interstitial lung disease. These antibodies may also appear in other autoimmune diseases like lupus or mixed connective tissue disease (MCTD), but with lower specificity.

Doctors may recommend the Scl-70 Antibody test if there are symptoms such as thickened or hardened skin, joint stiffness, Raynaud’s phenomenon, shortness of breath, or unexplained fatigue, which may suggest systemic sclerosis. Often performed alongside other antibody panels (such as ANA or ENA profiles), this test plays an important role in early detection, accurate disease classification, and guiding long-term treatment. By identifying these antibodies, doctors can monitor disease progression, anticipate potential organ involvement, and plan appropriate therapies.

Usually, no special preparation is required for this test. Eat and drink as per the daily routine. However, sharing the clinical history, current medications, and supplement use with the doctor before giving the sample is preferred, as these may influence the results.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate and always consult a doctor to understand the test results correctly. 

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.