ASCA - IgA antibody

Also referred as

Anti-Saccharomyces Cerevisiae Antibody IgA Test

Crohn's Disease Antibody Test

IgA Antibodies to Saccharomyces Cerevisiae Test

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The ASCA - IgA antibody test is a blood test that detects IgA antibodies against Saccharomyces cerevisiae, a yeast naturally present in the digestive tract. This test helps differentiate between types of inflammatory bowel disease (IBD), particularly Crohn’s disease and ulcerative colitis.

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Understanding ASCA - IgA antibody

Saccharomyces cerevisiae is a harmless yeast found in food, the body, and the environment. In certain individuals, the immune system reacts to this yeast and produces antibodies against it. These antibodies, called anti-Saccharomyces cerevisiae antibodies (ASCA), are commonly linked with Crohn’s disease. Specifically, the ASCA-IgA test looks for IgA antibodies, which are closely associated with mucosal immunity in the intestines.

Detecting ASCA-IgA helps doctors differentiate Crohn’s disease from ulcerative colitis, two major forms of IBD that affect different regions of the gastrointestinal tract and often need different treatment approaches. The test is recommended for patients with gastrointestinal symptoms such as long-standing diarrhea, abdominal pain, unexplained weight loss, or rectal bleeding, especially if the diagnosis is unclear.

No special preparation is needed for getting the ASCA - IgA antibody test done. However, be sure to inform the doctor about any medications or supplements being taken, as they may affect the test results.

Lab test results may vary across different laboratories. Abnormal test results require expert interpretation. Therefore, never try to self-medicate based solely on these results. Always consult a doctor for a proper understanding of the test results.

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.

What does ASCA - IgA antibody measure?

The ASCA - IgA antibody test measures IgA antibodies in the blood and is used in gastroenterology to help differentiate between inflammatory bowel diseases, specifically Crohn’s disease and ulcerative colitis. IgA antibodies are primarily associated with mucosal immunity in the intestines.

Elevated ASCA-IgA levels are often linked with Crohn’s disease, providing valuable information when symptoms overlap or are unclear. Detecting ASCA-IgA helps doctors make a more precise diagnosis and guide treatment strategies tailored to the specific type of IBD.

A positive result supports the likelihood of Crohn’s disease, though it is not definitive on its own. The test is most useful when interpreted alongside clinical symptoms, imaging, colonoscopy, and other laboratory results, helping distinguish Crohn’s disease from ulcerative colitis for accurate management.

Test Information is reviewed by: Dr. Swati Gupta (Anand), MBBS, MD Lab Medicine and written by Dr. Lipika Khurana, BDS, PGDHHM . The test details are for information purpose only. Consult a doctor before taking any test. Last updated on: 27th Sep 2026

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ASCA - IgA antibody test price for other cities

Price in	New Delhi	Rs. 1499
Price in	Mumbai	Rs. 2129
Price in	Kolkata	Rs. 1599
Price in	Chennai	Rs. 1599
Price in	Chandigarh	Rs. 1599

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FAQs related to ASCA - IgA antibody

What is the ASCA - IgA antibody test?

It is a blood test that detects IgA antibodies against Saccharomyces cerevisiae, a yeast commonly present in the digestive system. The test is primarily used to differentiate Crohn’s disease from ulcerative colitis, the two main types of inflammatory bowel disease.

Who should get this test?

Individuals with gastrointestinal symptoms such as diarrhea, abdominal pain, rectal bleeding, or unexplained weight loss should consider this test, especially when IBD is suspected, but the diagnosis is unclear.

How is the test performed?

A small blood sample is drawn from a vein in the arm and analyzed in the laboratory for ASCA-IgA antibodies.

What does a positive test result mean?

A positive ASCA-IgA result suggests a higher likelihood of Crohn’s disease. However, it should be interpreted along with clinical findings and other diagnostic tests for a conclusive diagnosis.

What does a negative test result mean?

A negative result does not rule out Crohn’s disease or other forms of IBD. Some patients with Crohn’s disease may not have detectable ASCA-IgA antibodies, and additional tests may be required.

Do I need to fast before the test?

No, fasting is not required unless specifically advised by your doctor.

Are there any risks with this test?

The test involves a simple blood draw. Risks are minimal, though some mild pain, bruising, or discomfort at the needle site may occur.

How is ASCA IgA different from ASCA IgG?

Both tests detect antibodies against Saccharomyces cerevisiae. IgG antibodies circulate in the blood, while IgA antibodies are associated with mucosal immunity in the intestines. Doctors may use both tests together for better diagnostic accuracy.

Can other conditions cause a positive ASCA-IgA test?

Yes. Although most commonly associated with Crohn’s disease, positive results may also occur in other forms of IBD and rarely in conditions like celiac disease.

Can someone without symptoms test positive for ASCA-IgA?

Yes, though this is uncommon. A positive test in the absence of symptoms does not confirm disease, and further evaluation may be needed if risk factors are present.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

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