Zidine 300mg Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 14 Apr 2026 | 04:21 PM (IST)

Zidine 300mg Tablet belongs to a group of medicines called antiretrovirals. It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS (acquired immunodeficiency syndrome). It helps to control HIV infection so your immune system can work better.

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General Information

Contains

Zidovudine (300mg)

Marketer

Emcure Pharmaceuticals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Zidine 300mg Tablet is not a cure for HIV or AIDS and only helps to decrease the amount of HIV in your body. This helps to lower your risk of getting HIV-related complications and improves your lifespan. It is prescribed in combination with other HIV medicines. Your doctor will recommend the best medicines for you and will decide the doses that you need. Follow carefully the instructions for all the medicines that you are given. It can be taken with or without food. Taking all these medicines regularly at the right times greatly increases their effectiveness and reduces the chances of HIV becoming resistant to them. It is important not to miss doses and to keep taking them until your doctor tells you it is safe to stop.

Common side effects of this medicine include headache, nausea, vomiting, stomach pain, fatigue, diarrhea, and rash. These are usually not serious but tell your doctor if they bother you or will not go away. Rarely, some people may experience a skin reaction or liver damage. Your doctor will closely monitor you for these in the initial period of treatment.

Before taking it, tell your doctor if you have any skin problems or liver or kidney disease. While using it, you may need regular blood tests to check your blood counts and liver function. Avoid drinking alcohol as it may increase your risk of liver damage. Pregnant or breastfeeding mothers should consult their doctor before using this medicine. Do not have unprotected sex or share personal items like razors or toothbrushes, if you are HIV positive. Talk to your doctor about safe ways like condoms to prevent HIV transmission during sex.

Uses of Zidine Tablet

HIV infection

Benefits of Zidine Tablet

HIV infection
Zidine 300mg Tablet reduces the amount of virus in the body, which helps protect and strengthen the immune system. By preventing the virus from replicating, it slows the progression of HIV, lowers the risk of complications, and improves overall health. When used as part of combination antiretroviral therapy (ART), Zidine 300mg Tablet helps manage the infection, enhancing the patient’s quality of life and reducing the risk of HIV-related conditions. It also plays a key role in preventing mother-to-child transmission of HIV during pregnancy.

Side effects of Zidine Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zidine

Rash
Headache
Decreased appetite
Nausea
Vomiting
Fever
General discomfort
Decreased white blood cell count (neutrophils)
Anemia (low number of red blood cells)
Cough

How to use Zidine Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zidine 300mg Tablet may be taken with or without food.

How Zidine Tablet works

Zidine 300mg Tablet is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.

Quick tips

In combination with other medicines, it is used for the treatment of HIV infections.
Take it with food, as this increases the absorption of the medicine into the body.
Zidine 300mg Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
You may still develop infections or other illnesses associated with viral infection while taking this medication.
You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus and blood cells in your blood.
You have been prescribed Zidine 300mg Tablet for the treatment of chronic hepatitis B virus (HBV) infection.
In combination with other medicines, it is used for the treatment of HIV infections.
Take it with food, as this increases the absorption of the medicine into the body.
Zidine 300mg Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
You may still develop infections or other illnesses associated with viral infection while taking this medication.
You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus and blood cells in your blood.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Zidine 300mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Zidine 300mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CAUTION

Zidine 300mg Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Zidine 300mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Zidine 300mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Zidine 300mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Zidine 300mg Tablet is not recommended in patients with moderate to severe liver disease.

Interaction with drugs

Taking Zidine with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Amphotericin B (Injection Route)

Your doctor may monitor your blood cell count for toxicity of medicines and adjust the doses as per the observations.

Severe

Amphotericin B (Vaginal Route)

Your doctor may monitor your blood cell count for toxicity of medicines and adjust the doses as per the observations.

Severe

Sodium Valproate (Oral Route)

Watch out for symptoms such as fatigue, weakness, abnormal bleeding, mouth ulcers, numbness, impaired coordination, or body aches, and consult your doctor if you experience them.

Severe

Sodium Valproate (Injection Route)

Watch out for symptoms such as fatigue, weakness, abnormal bleeding, mouth ulcers, numbness, impaired coordination, or body aches, and consult your doctor if you experience them.

Severe

Stavudine (Oral Route)

Do not consume Stavudine with Zidovudine. If concurrent use is essential, please consult your doctor. Zidovudine may block the action of Stavudine.

Frequently asked questions

What is Zidine 300mg Tablet? What is it used for?

Is Zidine 300mg Tablet safe?

Zidine 300mg Tablet is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.

How does Zidine 300mg Tablet work?

Zidine 300mg Tablet works by blocking the function of an enzyme, called reverse transcriptase, which is responsible for the HIV replication process. This helps to reduce the level of HIV in the blood.

How should I take Zidine 300mg Tablet?

Zidine 300mg Tablet should be taken in the dose and duration advised by the doctor. This medicine may be taken with or without food but it is better to be taken at a fixed time of the day to avoid the chances of missing a dose.

Is Zidine 300mg Tablet effective?

Zidine 300mg Tablet is effective if used in the dose and duration advised by your doctor. Do not stop taking it even if you see improvement in your condition. If you stop using Zidine 300mg Tablet too early, the symptoms may return or worsen.

What if I forget to take a dose of Zidine 300mg Tablet?

If you forget a dose of Zidine 300mg Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.

Fact Box

Chemical Class

Pyrimidine 2',3'- dideoxyribonucleosides

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs)

Related lab tests

HIV 1 & 2, Ab Western Blot

HIV 1 And 2 Antibody - Chromatography

HIV 1 And 2 Antibody - ELISA

References

Flexner C. Antiretroviral Agents and Treatment of HIV Infection. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1632-633.
Safrin S. Antiviral Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 860-61.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1506-514.
Zidovudine. South Ruislip, Middlesex: Aurobindo Pharma - Milpharm Ltd.; 2008 [revised 12 Nov. 2018]. [Accessed 31 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 31 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Emcure Pharmaceuticals Ltd
Address: 255/2, Hinjawadi, Pune - 411057, India / Godown A, Gat No. 408 and 410, Vill: Urse, Tal: Maval, Pune-410 506, Maharashtra, India.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Zidine 300mg Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Zidine Tablet

Benefits of Zidine Tablet

Side effects of Zidine Tablet

How to use Zidine Tablet

How Zidine Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Amphotericin B (Injection Route)

Amphotericin B (Vaginal Route)

Sodium Valproate (Oral Route)

Sodium Valproate (Injection Route)

Stavudine (Oral Route)

Frequently asked questions

What is Zidine 300mg Tablet? What is it used for?

Is Zidine 300mg Tablet safe?

How does Zidine 300mg Tablet work?

How should I take Zidine 300mg Tablet?

Is Zidine 300mg Tablet effective?

What if I forget to take a dose of Zidine 300mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

HIV 1 & 2, Ab Western Blot

HIV 1 And 2 Antibody - Chromatography

HIV 1 And 2 Antibody - ELISA

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests