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Zerofat 120mg Tablet

Written By Dr. Lipika Khurana, PGDHHM, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 20 Jan 2026 | 01:18 AM (IST)
Zerofat 120mg Tablet is a medicine used in the treatment of obesity. It helps the body in blocking the absorption of fats from the small intestines and stomach. This way it can help reduce calorie intake and weight loss over time.
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General Information

Contains

Orlistat (120mg)

Marketer

Mankind Pharma Ltd

Storage

Store below 30°C
The content is shown in English
Zerofat 120mg Tablet image
Zerofat 120mg Tablet image

Product introduction

Zerofat 120mg Tablet is geenrally taken orally 3 times daily, during (or up to 1 hour after) each main meal containing fat. It can also be taken up to 2 hours after midmeal. It works best when it is used along with regular physical activity and a healthy diet. It should not be taken for a long term unless your doctor tells you to do so. For better efficacy of the medicine, fat-rich foods should be avoided along with the medicine.

Some of the common side effects of Zerofat 120mg Tablet include the presence of fat in the stool, abdominal pain, and diarrhea. If any of the side effects bother you, tell your doctor without delay. They may be able to help you by adjusting your dose or prescribe you an alternate medicine.

Pregnant and breastfeeding women must take this medicine only with a valid prescription. Inform your doctor before taking the medicine if you have any other medical conditions or are taking any other medications. This medicine should not be considered as a long-term treatment unless you are prescribed by your doctor.

Uses of Zerofat Tablet

Benefits of Zerofat Tablet

Obesity
Zerofat 120mg Tablet is used in obesity to help reduce excess body weight. It supports individuals in achieving and maintaining weight loss when combined with a controlled diet and physical activity, contributing to improved overall health and quality of life.

Side effects of Zerofat Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zerofat
  • Fat in stool
  • Bowel incontinence
  • Flatus with discharge
  • Oily spotting
  • Oily evacuation
  • Increased bowel movements

How to use Zerofat Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zerofat 120mg Tablet should be taken with or after food.
Avoid Zerofat 120mg Tablet with high-fat meals such as olive oil, nuts & seeds (Brazil nuts), dark chocolate, butter and meat.

How Zerofat Tablet works

Zerofat 120mg Tablet is a lipase inhibitor. It works in the stomach and small intestine by blocking the absorption of fat from food by blocking enzymes responsible for the breakdown of fat.

All substitutes for Zerofat 120mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Slimodax 120mg Tablet

by Daxia Healthcare
₹48.1/tablet
127% costlier
<h3 class=bodySemiBold>Slimodax 120mg Tablet</h3>

Quick tips

  • Zerofat 120mg Tablet should be used along with regular physical activity and a healthy diet.
  • Take it during or up to 1 hour after each meal.
  • Skip your dose if you miss a meal or if your meal contains no fat.
  • A multivitamin supplement containing vitamins A, D, and K is recommended when taking Zerofat 120mg Tablet.
  • It should not be taken for longer than six months. If you have been unable to lose weight after 12 weeks of taking this medicine, you should stop taking it and consult your doctor.

Safety advice

Alcohol

Alcohol

SAFE
Consuming alcohol with Zerofat 120mg Tablet does not usually cause any harmful side effects.
Pregnancy

Pregnancy

UNSAFE
Zerofat 120mg Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Zerofat 120mg Tablet during breastfeeding is not available. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Zerofat 120mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Zerofat 120mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Zerofat 120mg Tablet in patients with liver disease.

Interaction with drugs

Taking Zerofat with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Ulipristal acetate (Oral Route)

watch out for severe diarrhea when taking Ulipristal acetate and Orlistat concurrently. Your doctor may recommend you to use barrier methods of contraception (like condoms) or copper IUD in case of severe diarrhea. Orlistat may reduce blood levels of Ulipristal acetate.
Severe

Levonorgestrel (Oral Route)

watch out for severe diarrhea when taking Levonorgestrel and Orlistat concurrently. Your doctor may recommend you to use barrier methods of contraception (like condoms) or copper IUD in case of severe diarrhea. Orlistat may reduce blood levels of Levonorgestrel.
Moderate

Glibenclamide (Oral Route)

Your doctor may monitor your diabetic control closely and adjust the dose of Orlistat as per the observations. Glibenclamide may raise blood levels of Orlistat and its active form.
Moderate

Progesterone (Natural Micronized) (Oral Route)

Watch out for severe diarrhea when taking Progesterone (Natural Micronized) and Orlistat concurrently. Your doctor may recommend you to use barrier methods of contraception (like condoms) or copper IUD in case of severe diarrhea. Orlistat may reduce blood levels of Progesterone (Natural Micronized).
Moderate

Metformin (Oral Route)

Your doctor may monitor your diabetic control closely and adjust the dose of Orlistat as per the observations. Orlistat may reduce blood levels of active form of Metformin.

Frequently asked questions

It is not advised to take Zerofat 120mg Tablet for more than 6 months. Consult your doctor and stop the medication if you do not experience any weight reduction 12 weeks after starting your treatment with Zerofat 120mg Tablet.
You should not take Zerofat 120mg Tablet if you are allergic to it, have difficulty absorbing food (chronic malabsorption syndrome), or have cholestasis (a condition where the flow of bile from the liver is blocked). Refrain from using Zerofat 120mg Tablet if you are taking cyclosporine medicine or blood thinners like warfarin. Along with that, avoid Zerofat 120mg Tablet if you are pregnant or breastfeeding.
You should stick to a low-calorie, low-fat diet while taking Zerofat 120mg Tablet. Having a high-fat meal with Zerofat 120mg Tablet might increase the chances of developing unpleasant side effects. Try to eat more vegetables and fruits, have small portions, eat regularly, and do not skip any meals.
Though alcohol does not interfere with the working of Zerofat 120mg Tablet, it is recommended that you cut down on or avoid alcohol. Alcohol contains calories, which will add to your weight. Hence, for effective weight reduction, it is best to avoid alcohol.
Zerofat 120mg Tablet starts working quickly, within 24-48 hours of taking it. You may even notice fat in your stools. However, it may take about a week or two to show effective weight reduction, which will vary from person to person.
Yes, exercise may prove to be very helpful for effective weight reduction and maintenance of reduced weight. An exercise program and low-calorie intake will help maintain your weight even after discontinuation of the medicine.
Zerofat 120mg Tablet belongs to a class of medicines known as lipase inhibitors. It targets the fat that you eat. It prevents about 25% of fat in your meals from being absorbed. This unabsorbed fat will get passed in the stools and removed from the body.
Take Zerofat 120mg Tablet three times a day and swallow the capsule whole with water. Take it just before, during, or up to one hour after meals. The meal should be well-balanced and should include low-calorie ingredients. Do not take Zerofat 120mg Tablet if you miss a meal or your meal does not contain fat, as it will not work in the absence of fat.
You should set a realistic goal of weight reduction. Aim to reduce 5-10% of your starting weight. This weight loss process should be gradual and at a steady pace. You should try to reduce by 0.5 kg per week.

Fact Box

Chemical Class

Leucine derivative

Habit Forming

No

Therapeutic Class

OTHERS

Action Class

Lipase Inhibitors

Related lab tests

Cholesterol - LDL

References

  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1030-31.
  2. Orlistat [EMC SmPC]. GlaxoSmithKline Consumer Healthcare; 2018. [Accessed 05 Apr. 2019] (online) Available from:
  3. Central Drugs Standard Control Organisation (CDSCO). Orlistat. [Accessed 03 Apr. 2019] (online) Available from:
  4. Orlistat [Package Insert]. Mehsana, Gujarat: Torrent Pharmaceuticals Ltd. [Accessed 03 Aug. 2023] (online) Available from:
  5. Orlistat [Prescribing Information]. Montgomery, AL: H2-Pharma, LLC; 2026. [Accessed 03 Aug. 2023] (online). Available from:
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User feedback

Twice A Day
32%
Once A Day
23%
Alternate Day
19%
Thrice A Day
19%
Thrice A week
4%
Twice A Week
2%
Four Times A Day
2%
Obesity
96%
Others
4%
Poor
48%
Average
32%
Excellent
19%
No Side Effect
67%
Flatulence
33%
With food
83%
Empty stomach
8%
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Mankind Pharma Ltd
Address: 208, Okhla Industrial Estate, Phase III, New Delhi - 110020

Vendor Details

Country of origin: India

Lab tests offered by us

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