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    Information about Glibenclamide

    Glibenclamide uses

    Glibenclamide is used in the treatment of type 2 diabetes mellitus. It is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes.

    How glibenclamide works

    Glibenclamide is an antidiabetic medication. It works by increasing the amount of insulin released by the pancreas in order to lower blood glucose.

    Common side effects of glibenclamide

    Hypoglycemia (low blood glucose level), Nausea, Headache, Dizziness
    Content Details
    Written By
    Dr. Betina Chandolia
    MDS, BDS
    Reviewed By
    Dr. Lalit Kanodia
    MD (Pharmacology), MBBS
    Last updated on:
    02 Apr 2020 | 11:17 AM (IST)
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    Read Our Editorial Policy

    Available Medicine for Glibenclamide

    • ₹40 to ₹67
      Emcure Pharmaceuticals Ltd
      2 variant(s)
    • ₹12
      1 variant(s)
    • ₹6
      Emcure Pharmaceuticals Ltd
      1 variant(s)
    • ₹3 to ₹8
      Aristo Pharmaceuticals Pvt Ltd
      3 variant(s)
    • ₹23
      Aretaeus Pharmaceuticals
      1 variant(s)
    • ₹11
      Cipla Ltd
      1 variant(s)
    • ₹5
      Acron Pharmaceuticals
      1 variant(s)
    • ₹2 to ₹6
      Sun Pharmaceutical Industries Ltd
      2 variant(s)
    • ₹5
      1 variant(s)
    • ₹5 to ₹7
      USV Ltd
      2 variant(s)

    Expert advice for Glibenclamide

    • Take it shortly before or with the first main meal of the day (usually breakfast). Avoid skipping meals.
    • Be careful while driving or operating machinery until you know how Glibenclamide affects you.
    • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
    • Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor and anxiety.
    • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms, such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

    Frequently asked questions for Glibenclamide


    Q. Is Glibenclamide the same as Glipizide?

    No, Glibenclamide and Glipizide are different medicines. However, they belong to the same class of medicines called sulfonylureas and are used to treat type 2 diabetes mellitus in adults.

    Q. Does Glibenclamide play any role in the treatment of polycystic ovarian syndrome (PCOS)?

    No, Glibenclamide is not known to have any role in the treatment of polycystic ovarian syndrome (PCOS). Also, there is no clinical evidence available regarding the same.

    Q. Why should Glibenclamide be used cautiously in elderly patients?

    Glibenclamide should be used with extra caution in elderly patients because they are at high risk of getting low blood sugar (hypoglycemic event).

    Q. Is Glibenclamide useful in the management of prediabetes?

    Glibenclamide is not used for the management of prediabetes, a condition with blood glucose levels higher than normal but not high enough to label you as diabetic. There are clinical studies available, but the evidence is not strong enough for its use in prediabetes.

    Q. How is Glibenclamide different from Teneligliptin?

    Both Glibenclamide and Teneligliptin are antidiabetic medicines and control blood sugar levels effectively. However, they work in different ways and may show different kinds of side effects. Glibenclamide commonly causes hypoglycemia and weight gain while Teneligliptin causes headache and nasopharyngitis. Teneligliptin causes hypoglycemia when used along with insulins or sulfonylureas and does not cause weight gain.

    Q. Can I skip Glibenclamide for a few days?

    No, Glibenclamide should not be skipped as it can make your diabetes worse. If you miss the dose by mistake, take it as soon as you remember.

    Q. Can I take Glibenclamide if I have a sulfa allergy?

    Use of Glibenclamide should be avoided if you are allergic (hypersensitive) to sulfonylureas or sulfonamides or any of the other ingredients of this medicine.

    Q. Does Glibenclamide cause weight gain?

    Yes, Glibenclamide can cause weight gain. It is advisable to closely monitor your diet and exercise regularly while taking this medicine. Avoid skipping your meals as it can cause very low blood sugar levels and you may end up snacking or taking a lot of sugars.

    Q. Is there any benefit of taking Glibenclamide with insulin?

    Glibenclamide, when used with insulin, can help to control high blood sugar levels. Taking them together can help to lower the dose of insulin but there could also be an increased risk of hypoglycemia (low blood sugar levels). The dose of these medicines may need to be adjusted along with regular blood sugar level monitoring. Please consult your doctor if you have any doubts and follow your doctor's instructions carefully to get maximum benefit of Glibenclamide.

    Q. Is it safe to take Glibenclamide with Liraglutide?

    Yes, Glibenclamide and Liraglutide can be taken together, as they can help in better control of blood sugar levels. However, the risk of low blood sugar levels (hypoglycemia) can increase. Consult your doctor as a dose adjustment of the two may be needed.

    Q. Is Glibenclamide a Thiazolidinedione?

    No, Glibenclamide is not a Thiazolidinedione, it is a sulfonylurea. However, both are antidiabetic medicines but belong to a different group of medicines.

    Q. Is Glibenclamide useful in the management of gestational diabetes?

    Glibenclamide is not advised to be used for the management of gestational diabetes. The use of insulin is advised during pregnancy to control the blood glucose levels. However, do not start taking Glibenclamide until prescribed by the doctor.

    Q. Does Glibenclamide cause hair loss?

    No, hair loss is not seen with the use of Glibenclamide. However, diabetes can lead to hair loss. Talk to your doctor if you have excessive hair loss as it could be due to some other underlying condition or it could be a sign of your diabetes getting worsened.

    Q. Is it safe to take Glibenclamide with pioglitazone?

    Yes, it is safe to take Glibenclamide with Pioglitazone in patients with diabetes mellitus. Together these two medicines can control your blood sugar levels, lower plasma lipid levels and improve blood pressure. However, the risk of very low blood sugar levels can increase and the dose of these medicines may need to be adjusted.

    Content on this page was last updated on 02 April, 2020, by Dr. Varun Gupta (MD Pharmacology)