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    Information about Glibenclamide

    Glibenclamide uses

    Glibenclamide is used in the treatment of type 2 diabetes. It is used in addition to diet and exercise to improve blood sugar control in adults with type 2 diabetes.

    How glibenclamide works

    Glibenclamide is an anti-diabetic medication (sulphonylurea). It works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose.

    Common side effects of glibenclamide

    Hypoglycemia (low blood sugar level), Nausea, Headache, Dizziness

    Available Medicine for Glibenclamide

    • ₹40 to ₹67
      Emcure Pharmaceuticals Ltd
      2 variant(s)
    • ₹12
      1 variant(s)
    • ₹6
      Emcure Pharmaceuticals Ltd
      1 variant(s)
    • ₹2 to ₹7
      Aristo Pharmaceuticals Pvt Ltd
      3 variant(s)
    • ₹5
      1 variant(s)
    • ₹4
      Biochem Pharmaceutical Industries
      1 variant(s)
    • ₹10
      Cipla Ltd
      1 variant(s)
    • ₹6 to ₹12
      Strides shasun Ltd
      2 variant(s)
    • ₹2 to ₹5
      Cadila Pharmaceuticals Ltd
      2 variant(s)
    • ₹5 to ₹7
      USV Ltd
      2 variant(s)

    Expert advice for Glibenclamide

    • Helps decrease high blood sugar level and avoids long-term complications of diabetes. 
    • Take just before or with the first main meal of the day (usually breakfast). Avoid skipping meals.
    • Exercise regularly, eat a healthy diet, and take your other diabetes medicines (if prescribed) alongside.
    • Learn how to identify and manage symptoms of hypoglycemia (low blood sugar level) such as sweating, rapid heartbeat, weakness, blurry vision, and headache, and teach your family as well.
    • Avoid drinking alcohol.

    Frequently asked questions for Glibenclamide


    Q. Is glibenclamide same as glipizide?

    No. Glibenclamide and glipizide are different medicines; however, they belong to same family of drugs called sulfonylureas

    Q. Does Glibenclamide play any role in the treatment of Polycystic ovarian syndrome (PCOS)?

    No, Glibenclamide is not known to have any role in the treatment of polycystic ovarian syndrome (PCOS). Also, there is no clinical evidence available regarding the same.

    Q. Why Glibenclamide should be cautiously used in elderly patients?

    Glibenclamide should be used with extra caution in elderly patients because they are at high risk of getting low blood sugar (hypoglycemic event)

    Q. Is Glibenclamide useful in the management for prediabetes?

    The Glibenclamide is not used for the management of prediabetes, a condition with blood glucose levels higher than normal but not high enough to label you as diabetic. There are clinical studies available, but the evidence is not strong enough for its use in prediabetes.

    Q. How is Glibenclamide different from teneligliptin?

    Both Glibenclamide and teneligliptin are antidiabetic drugs and control blood sugar levels effectively. However, they work in different ways and have a different mechanism of action and side effects. Glimepiride commonly causes hypoglycemia and weight gain while teneligliptin causes headache and nasopharyngitis. Teneligliptin causes hypoglycemia when used along with insulins or sulfonylureas and does not cause weight gain.

    Q. Can I skip Glibenclamide for few days?

    No, Glibenclamide should not be skipped, as it can make your diabetes worse. If you miss the dose by mistake, take it as soon as you remember.

    Q. Can I take Glibenclamide if I have a sulfa allergy?

    Use of Glibenclamide should be avoided if you are allergic (hypersensitive) to sulfonylureas or sulfonamides or any of the other ingredients of this medicine

    Q. Does Glibenclamide cause weight gain?

    Yes, Glibenclamide can cause weight gain. It is advisable to closely monitor your diet and do regular exercise while taking this medicine. Avoid skipping your meal as it can cause very low blood sugar levels and you may end up snacking or taking a lot of sugars.

    Q. Is there any benefit of taking Glibenclamide with insulin?

    Glibenclamide, when used with insulin, can help to control high blood sugar levels. Taking them together can help to lower the dose of insulin but there could also be an increased risk of hypoglycemia. Dose of these medicines may need to be adjusted along with regular blood sugar level monitoring

    Q. Is it safe to take Glibenclamide with liraglutide?

    Yes, Glibenclamide and liraglutide can be taken together, as they can help in better control of blood sugar levels. However, the risk of low blood sugar levels (hypoglycemia) can increase. Consult your doctor as a dose adjustment of the two may be needed.

    Q. Is Glibenclamide a Thiazolidinedione?

    No, Glibenclamide is not a Thiazolidinedione, it is a sulfonylurea. However, both are antidiabetic medicines but belong to a different group of medicines.

    Q. Is Glibenclamide useful in the management of gestational diabetes?

    Glibenclamide is not advised to be used for the management of gestational diabetes. Use of Insulin is advised during pregnancy to control the blood glucose levels

    Q. Does Glibenclamide cause hair loss?

    No, hair loss is not seen with the use of Glibenclamide. However, diabetes itself can lead to hair loss. Talk to your doctor if you have excessive hair loss as it could be due to some other underlying condition or it could be a sign of your diabetes getting worsened.

    Q. Is it safe to take Glibenclamide with pioglitazone?

    Yes, it is safe to take Glibenclamide with Pioglitazone in patients with diabetes mellitus. Together they can control your blood sugar levels, lower plasma lipid levels and improve blood pressure. However, the risk of very low blood sugar levels can increase and the dose of these medicines may need to be adjusted.

    Content on this page was last updated on 07 May, 2018, by Dr. Varun Gupta (MD Pharmacology)