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Glibenclamide is used to lower the blood sugar level in patients with type 2 diabetes mellitus that is not controlled by diet and exercise alone.

How it works

Glibenclamide also known as glyburide is one of a group of medicines called sulphonylurea and it acts by promoting insulin secretion in the body, so that the blood sugars are utilized by various organs, leading to a fall in blood levels of sugar. 

Common side effects

Nausea, Anxiety, Bruise, Bleeding, Dark colored urine, Diarrhoea, Fever, Dizziness, Flatulence, Loss of appetite, Rash, Itching, Skin redness, Sore throat, Stomach pain / epigastric pain


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Expert advice

Make sure you follow all exercise and dietary recommendations made by your doctor or dietitian. Swallow the whole tablet with or immediately after breakfast or the first main meal.Take glibenclamide exactly as directed by your doctor. Do not stop taking glibenclamide without consulting your doctor. Do not take glibenclamide;
  • If you are allergic to glibenclamide or any of the other ingredients of this medicine.
  • If you have type 1 diabetes mellitus or have had impaired consciousness due to severe diabetes, liver or kidney disease, or deficiency of an enzyme called glucose-6-phosphate dehydrogenase (G6PD).
  • If you are pregnant or breast-feeding.
Do inform your doctor if you are about to have major surgery or have had a recent injury (trauma) or develop a fever or severe infection.

Frequently asked questions


Q. Is glibenclamide/Daonil/Euglucon same as glyburide?
Yes. Daonil/ Euglucon are the trade names for the active substance (generic) glibenclamide/ glyburide; thus, they all are same.
Q. Is glibenclamide same as glipizide?
No. Glibenclamide and glipizide are different medicines; however, they belong to same family of drugs called sulfonylureas.
Q. Why is glibenclamide avoided in the elderly?
Glibenclamide should be avoided in elderly patients because they are at high risk of getting low blood sugar (hypoglycemic event).
Q. What is glibenclamide/Daonil/ Euglucon used for?
Glibenclamide/Daonil/ Euglucon is used for the treatment of type 2 diabetes.
Q. Does Daonil/ glibenclamide cause weight gain/ weight loss?
Yes Daonil/ glibenclamide are known to cause weight gain but not weight loss. Always consult your doctor if you experience such side effects.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)