
UrsoEdge 150 Tablet
Written By Dr. Lipika Khurana, PGDHHM, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 13 Apr 2026 | 11:38 AM (IST)
UrsoEdge 150 Tablet is used to treat cholesterol gallstones, primary biliary cirrhosis, primary sclerosing cholangitis, and liver disease associated with cystic fibrosis. It works by improving bile flow and breaking down excess cholesterol in bile, helping dissolve gallstones and protect the liver from damage.
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General Information
Contains
Ursodeoxycholic Acid (150mg)
Salt Synonyms
Ursodiol
Marketer
Pledge Pharma Pvt. Ltd.
Storage
Store below 25°C
The content is shown in English







Product introduction
Take UrsoEdge 150 Tablet after a meal and with a glass of milk or water. The dose will depend on what you are being treated for and your health condition. Take it regularly to get maximum benefit, and keep taking it for as long as prescribed (several months or longer). Keep taking it even if your symptoms disappear.
The most common side effects of UrsoEdge 150 Tablet are abdominal pain, diarrhea, hair loss, itching, nausea, and rash. Not everyone gets these side effects. If you are worried about them or they do not go away, let your doctor know. They may be able to suggest ways to manage them or prescribe an alternative medicine.
Before taking this medicine, tell your doctor if you have gallbladder or bile duct inflammation, frequent cramp-like pain in your upper abdomen, blood in your cough, or rapid weight gain. Using this medicine can increase or decrease the effects of other medicines, so tell your doctor about all the other medicines you are taking. Pregnant and breastfeeding women should consult their doctor before using this medicine to make sure it is safe for them.
The most common side effects of UrsoEdge 150 Tablet are abdominal pain, diarrhea, hair loss, itching, nausea, and rash. Not everyone gets these side effects. If you are worried about them or they do not go away, let your doctor know. They may be able to suggest ways to manage them or prescribe an alternative medicine.
Before taking this medicine, tell your doctor if you have gallbladder or bile duct inflammation, frequent cramp-like pain in your upper abdomen, blood in your cough, or rapid weight gain. Using this medicine can increase or decrease the effects of other medicines, so tell your doctor about all the other medicines you are taking. Pregnant and breastfeeding women should consult their doctor before using this medicine to make sure it is safe for them.
Uses of UrsoEdge Tablet
- Treatment of Gallbladder stones
- Treatment of Primary biliary cirrhosis
Benefits of UrsoEdge Tablet
Treatment of Gallbladder stones
UrsoEdge 150 Tablet is a medicine that helps decreases the amount of cholesterol produced by your liver. It helps to break down cholesterol that has formed into “stones” in the gallbladder. It may take several months to completely dissolve the stone, so you need to take the medicine regularly and as long as the doctor has prescribed it for it to be effective. There might be other medicines and certain lifestyle changes that can reduce your cholesterol level and make gallstones less likely, consult with your doctor.
UrsoEdge 150 Tablet is a medicine that helps decreases the amount of cholesterol produced by your liver. It helps to break down cholesterol that has formed into “stones” in the gallbladder. It may take several months to completely dissolve the stone, so you need to take the medicine regularly and as long as the doctor has prescribed it for it to be effective. There might be other medicines and certain lifestyle changes that can reduce your cholesterol level and make gallstones less likely, consult with your doctor.
Treatment of Primary biliary cirrhosis
Primary biliary cirrhosis is a condition where bile ducts in the liver are damaged, leading to bile buildup. UrsoEdge 150 Tablet helps improve bile flow and reduce liver inflammation. This slows disease progression and relieves symptoms such as fatigue and itching. Take it regularly to support long-term liver function.
Primary biliary cirrhosis is a condition where bile ducts in the liver are damaged, leading to bile buildup. UrsoEdge 150 Tablet helps improve bile flow and reduce liver inflammation. This slows disease progression and relieves symptoms such as fatigue and itching. Take it regularly to support long-term liver function.
Side effects of UrsoEdge Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of UrsoEdge
- Abdominal pain
- Diarrhea
- Nausea
- Rash
- Hair loss
- Cough
- Sinus inflammation
- Upper respiratory tract infection
- Urinary tract infection
- Allergy
- Chest pain
- Dyspepsia
- Abdominal discomfort
- Headache
- Itching
- Back pain
- Fatigue
- Flatulence
- Vomiting
- Joint pain
- Joint inflammation
- Muscle pain
- Insomnia (difficulty in sleeping)
- Bronchitis (inflammation of the airways)
How to use UrsoEdge Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. UrsoEdge 150 Tablet should be taken with or after food.
How UrsoEdge Tablet works
UrsoEdge 150 Tablet is a hepatoprotective medication. It works by reducing the amount of cholesterol in the blood and helps dissolve gallbladder stones that are composed mainly of cholesterol. It also improves liver enzymes, protects liver cells from injury caused due to toxic bile acids, and improves liver function.
All substitutes for UrsoEdge 150 Tablet
For information purposes only. Consult a doctor before taking any medicine.
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Quick tips
- Take UrsoEdge 150 Tablet after a meal with a glass of milk or water to help improve its absorption and reduce stomach upset.
- Take UrsoEdge 150 Tablet regularly at the same time each day, as it works gradually and may take time to show beneficial results.
- Follow a healthy diet and exercise regularly, and avoid alcohol while taking UrsoEdge 150 Tablet.
- Avoid heavy or oily meals, as high-fat foods may worsen gallbladder or liver-related symptoms.
- Diarrhea may occur as a side effect. Drink plenty of fluids, including oral rehydration solution (ORS), and inform your doctor if it persists or if you notice blood in your stools.
- Your doctor may monitor liver function tests and bilirubin levels regularly, especially during the first few months of the treatment.
- Seek medical advice promptly if you develop worsening jaundice, severe itching, dark urine, pale stools, persistent abdominal pain, or fever.
- Do not stop taking UrsoEdge 150 Tablet without consulting your doctor, as liver conditions often require monitored and continuous therapy.
- Inform your doctor about all other medicines, herbal products, or supplements you are taking to avoid potential interactions.
Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with UrsoEdge 150 Tablet. Please consult your doctor.

Pregnancy
CONSULT YOUR DOCTOR
The safety of UrsoEdge 150 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of UrsoEdge 150 Tablet during breastfeeding is not available. Please consult your doctor.

Driving
SAFE
UrsoEdge 150 Tablet does not usually affect your ability to drive.

Kidney
CONSULT YOUR DOCTOR
There is limited data available on the use of UrsoEdge 150 Tablet in patients with kidney disease. Please consult your doctor.

Liver
SAFE IF PRESCRIBED
UrsoEdge 150 Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.
Interaction with drugs
Taking UrsoEdge with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate
Magaldrate (Oral Route)
Ensure a gap of at least 2 hours between taking Ursodeoxycholic Acid and Magaldrate.
Moderate
Allylestrenol (Oral Route)
Careful consideration is advised when taking Ursodeoxycholic Acid with Allylestrenol. Your doctor may monitor your treatment and adjust the doses as per the observations.
Moderate
Bezafibrate (Oral Route)
Do not consume Ursodeoxycholic Acid with Bezafibrate. If concurrent use is essential, your doctor may monitor the effects of Ursodeoxycholic Acid along with your overall treatment and adjust the doses as per the observations. Bezafibrate may reduce the efficacy of Ursodeoxycholic Acid.
Moderate
Cholestyramine (Oral Route)
Ensure a gap of at least 2 hours between taking Ursodeoxycholic Acid and Cholestyramine. Your doctor may monitor the effects of Ursodeoxycholic Acid. Cholestyramine may reduce blood levels of Ursodeoxycholic Acid.
Moderate
Colesevelam (Oral Route)
Ensure a gap of at least 4 hours between taking Ursodeoxycholic Acid and Colesevelam. Your doctor may monitor your treatment and adjust the doses as per the observations. Colesevelam may reduce blood levels of Ursodeoxycholic Acid.
Frequently asked questions
UrsoEdge 150 Tablet should usually be taken with food or milk to help your body absorb it better and to reduce the chance of stomach upset. Taking it at the same time every day helps maintain a steady level of the medicine in your body. If you consume antacids that contain aluminum, they may interfere with how well UrsoEdge 150 Tablet is absorbed. Taking it with a moderately high-fat meal (e.g., meals containing milk, curd, nuts, or oils) may further help in the absorption of ursodeoxycholic acid by promoting bile secretion.
UrsoEdge 150 Tablet is generally well tolerated. Common side effects include diarrhea (most frequent), nausea, and abdominal discomfort. These are usually mild and temporary. Rarely, it may alter liver enzyme levels, especially with long-term use, so your doctor may recommend periodic monitoring.
UrsoEdge 150 Tablet contains ursodeoxycholic acid and is mainly used to dissolve certain cholesterol gallstones and to treat liver diseases such as primary biliary cholangitis. It works by lowering cholesterol levels in bile, improving bile flow, and protecting liver cells from damage. This can help reduce elevated liver enzyme levels and support overall liver function. It should only be used after proper evaluation and diagnosis by your doctor.
Although uncommon, UrsoEdge 150 Tablet may lead to weight gain, which has been reported in some patients with specific liver conditions, where bile flow was reduced. The likelihood varies depending on the underlying diseases and individual response. If you notice unexpected weight gain while taking UrsoEdge 150 Tablet, please consult your doctor.
While taking UrsoEdge 150 Tablet, avoid certain medications, such as antacids, cholestyramine, and colestipol, as they may reduce its effectiveness. Hormonal medications that contain estrogen and drugs such as clofibrate may increase the risk of gallstones and interfere with the treatment. Alcohol should be limited or avoided because it can strain the liver and reduce the protective effects of UrsoEdge 150 Tablet. Always inform your doctor about all medications, supplements, and your lifestyle habits.
The body typically does not develop resistance to UrsoEdge 150 Tablet, unlike with antibiotics. However, if gallstones become hardened with calcium and do not dissolve with UrsoEdge 150 Tablet, or if bile flow does not improve and liver enzyme levels remain elevated, it may indicate progression of the underlying condition.
There are no strict food restrictions while taking UrsoEdge 150 Tablet, but it is best to avoid very greasy or spicy foods, as they can trigger gallbladder discomfort and worsen symptoms. A balanced, high-fiber diet may support digestion and overall treatment effectiveness. Always follow any specific dietary recommendations your doctor provides.
UrsoEdge 150 Tablet works by altering bile composition in the gallbladder, creating conditions that allow cholesterol gallstones to slowly dissolve back into liquid bile. This process is gradual and only works for stones primarily made of cholesterol. The gallbladder must still be functioning properly for treatment to be effective. Your doctor may recommend periodic ultrasounds to monitor the treatment progress.
The duration of treatment with UrsoEdge 150 Tablet depends on your medical condition and response to therapy. For fatty liver disease, it may be prescribed for a few months, while chronic conditions such as primary biliary cholangitis may require long-term use. When taken under medical supervision, UrsoEdge 150 Tablet is generally safe for extended treatment. Regular blood tests and imaging studies may be needed to monitor your liver function and ensure ongoing safety and effectiveness.
In rare cases, UrsoEdge 150 Tablet may cause dry skin or a mild rash. Staying well hydrated supports overall health and liver function. Drinking adequate fluids and using a gentle moisturizer may help if mild dryness occurs. If you experience a severe skin reaction, stop taking UrsoEdge 150 Tablet and contact your doctor immediately.
You should seek immediate medical attention if you develop severe right-sided abdominal pain, intense yellowing of the skin or eyes (jaundice), or severe and persistent diarrhea. These symptoms may indicate a blocked bile duct or a rare, serious reaction. Any unusual or worsening symptoms should be reported to your doctor promptly.
Fact Box
Chemical Class
Dihydroxy bile acid derivative
Habit Forming
No
Therapeutic Class
GASTRO INTESTINAL
Action Class
Hepatoprotective Agents
Related lab tests
References
- Ursodiol [Prescribing Information]. Birmingham, Alabama: Axcan Pharma US, Inc.; 2009. [Accessed 25 Jan. 2019] (online) Available from:
- Ursodiol [Prescribing Information]. Bridgewater, New Jersey: Aptalis Pharma US, Inc.; 2013. [Accessed 28 Mar. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Ursodiol. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:
- Ursodeoxycholic [Package Insert]. Mumbai, India: Alkem Laboratories Ltd.; 2016. [Accessed 07 Aug. 2023]. (online) Available from:
- The Lancet. Gastroenterology and Hepatology. [Accessed 07 Aug. 2023]. (online) Available from:
- Ursodeoxycholic Acid [Package Insert]. Hertfordshire, UK: Glenmark Pharmaceuticals Europe Limited; 2019. [Accessed 03 Feb. 2025]. (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Pledge Pharma Pvt. Ltd.
Address: 50/2/17 Central Road,Panchali Apartment, Ananda Puri,Barrackpore, Kolkata - 700122
Address: 50/2/17 Central Road,Panchali Apartment, Ananda Puri,Barrackpore, Kolkata - 700122
Vendor Details
Country of origin: India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)
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